Exploring Baicalein: A Natural Flavonoid for Enhancing Cancer Prevention and Treatment DOI Creative Commons

Madhu Hegde,

Panikar Sathyaseelan Archana, Kamalesh Dattaram Mumbrekar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40809 - e40809

Published: Nov. 29, 2024

Language: Английский

The most recent progress of baicalein in its anti-neoplastic effects and mechanisms DOI Open Access

Chenjing Lei,

Yaya Yu,

Yanjuan Zhu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116862 - 116862

Published: June 7, 2024

Problems, such as toxic side effects and drug resistance of chemoradiotherapy, target therapy immunotherapy accompanying the current anti-cancer treatments, have become bottlenecks limiting clinical benefit for patients. Therefore, it is urgent to find promising strategies with higher efficacy lesser effects. Baicalein, a flavonoid component derived from Chinese medicine scutellaria baicalensis, has been widely studied its remarkable activity in multiple types malignancies both at molecular cellular levels. Baicalein exerts anti-tumor by inhibiting angiogenesis, invasion migration, inducing cell apoptosis cycle arrest, well regulating autophagy, metabolism, tumor microenvironment cancer stem cells no obvious The role classic signaling pathways, PI3K/AKT/mTOR, MAPK, AMPK, Wnt/β-catenin, JAK/STAT3, MMP-2/-9, highlighted major targets baicalein exerting anti-malignant potential. Besides, can regulate relevant non-coding RNAs, lncRNAs, miRNAs circ-RNAs, inhibit tumorigenesis progression. In addition mentioned commonalities, shows some specific characteristics types. Moreover, preclinical studies combination chemoradiotherapy pave way ahead developing an adjunct treatment chemoradiotherapy. Our aim summary different mechanisms based on vitro vivo experiments, hoping providing proof serving effective safe compound clinic future.

Language: Английский

Citations

10
Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments DOI

Gaotao Zhang,

Zhiqin Liu,

Yuanzhuang Xu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117297 - 117297

Published: March 1, 2025

Language: Английский

Citations

0
The Therapeutic Potential of Baicalin and Baicalein in Breast Cancer: A Systematic Review of Mechanisms and Efficacy DOI Creative Commons
Bartłomiej Zieniuk, Şuheda Uğur

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 181 - 181

Published: March 11, 2025

Cancer remains a leading cause of death globally, with breast cancer being the most commonly diagnosed in women. This systematic review focuses on therapeutic potential baicalin and baicalein, two bioactive flavonoids derived from Scutellaria baicalensis, treatment. These compounds exhibit anticancer properties through mechanisms such as apoptosis induction, cell cycle arrest, inhibition metastasis. Baicalin baicalein modulate key signaling pathways, including NF-κB, PI3K/AKT/mTOR, Wnt/β-catenin, have shown efficacy both vitro vivo models. Their synergy chemotherapy agents incorporation into nanotechnology-based delivery systems highlight opportunities to enhance outcomes. However, current evidence is predominantly preclinical, limited clinical trials validate their safety humans. Challenges poor bioavailability rapid metabolism also underscore need for advanced formulation strategies. synthesizes molecular mechanisms, efficacy, applications research.

Language: Английский

Citations

0
Exploring Baicalein: A Natural Flavonoid for Enhancing Cancer Prevention and Treatment DOI Creative Commons

Madhu Hegde,

Panikar Sathyaseelan Archana, Kamalesh Dattaram Mumbrekar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40809 - e40809

Published: Nov. 29, 2024

Language: Английский

Citations

2