Invasion and metastasis in cancer: molecular insights and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

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Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 267, P. 155838 - 155838

Published: Feb. 11, 2025

Language: Английский

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Plant polyphenols in gastric cancer: Nature's healing touch

Seminars in Oncology, Journal Year: 2025, Volume and Issue: 52(2), P. 152333 - 152333

Published: March 11, 2025

Language: Английский

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Extracellular Vesicles: Hermes Between Cancers and Lymph Nodes

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217735 - 217735

Published: April 1, 2025

Language: Английский

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Emerging roles of non-coding RNA derived from extracellular vesicles in regulating PD-1/PD-L1 pathway: insights into cancer immunotherapy and clinical applications

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 23, 2025

Abstract Numerous studies have demonstrated that extracellular vesicles (EVs) carry a variety of noncoding RNAs (ncRNAs), which can be taken up by neighboring cells or transported to distant sites via bodily fluids, thereby facilitating intercellular communication and regulating multiple cellular functions. Within the tumor microenvironment, EV-ncRNA, on one hand, regulate expression PD-L1, influencing immune evasion, promoting cell proliferation, enhancing growth, invasion, metastasis in vivo. On other these specific EV-ncRNAs also modulate functions (such as CD8 + T cells, macrophages, NK cells) through various molecular mechanisms, inducing an immunosuppressive microenvironment resistance anti-PD-1 therapy. Therefore, delving into mechanisms underlying EV-ncRNA regulation checkpoints presents compelling therapeutic prospects for strategies selectively target EV-ncRNAs. In this review, we elaborate cutting-edge research progress related context cancer dissect their pivotal roles PD-1/PD-L1 checkpoint pathway. We highlight promising clinical applications anti-PD-1/PD-L1 immunotherapy, bridging basic with practical applications. Graphical

Language: Английский

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Overexpression of microRNA-611 inhibits TGF-β-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1

Cellular Signalling, Journal Year: 2024, Volume and Issue: 123, P. 111357 - 111357

Published: Aug. 22, 2024

Language: Английский

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