Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4809 - 4809

Published: April 27, 2022

The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. can cause acute respiratory distress, myocarditis, and systemic inflammatory response severe cases. interaction spike protein with angiotensin-converting enzyme various tissues causes damage to vital organs tissues, leading complications post-infection period. Vaccines antiviral drugs have improved patient but long-term effect on still unknown. Investigations are now focused supportive nutrient therapies, mitigate susceptibility as well COVID-19. Selenium one such micronutrient that plays role preventing oxidative stress induced by virus. Further, selenium important for effective immune response, controlling inflammation, maintain overall health humans. We examine aspects address importance supplementation reducing severity this review.

Language: Английский

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Community Wastewater-Based Surveillance Can Be a Cost-Effective Approach to Track COVID-19 Outbreak in Low-Resource Settings: Feasibility Assessment for Ethiopia Context

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(14), P. 8515 - 8515

Published: July 12, 2022

Wastewater surveillance systems have become an important component of COVID-19 outbreak monitoring in high-income settings. However, its use most low-income settings has not been well-studied. This study assessed the feasibility and utility wastewater system to monitor SARS-CoV-2 RNA Addis Ababa, Ethiopia. The was conducted at nine Membrane Bio-reactor (MBR) processing plants. samples were collected two separate time series. known leftover RT-PCR tested nasopharyngeal swabs processed using extraction protocols with different sample conditions. testing RIDA GENE RUO protocol for testing. adaptation, optimization, detection Ethiopia context. Samples during first series, when national case load low, all negative. Conversely, second series positive, coinciding highest daily reported new cases wastewater-based approach is feasible Ababa. based epidemiological can potentially fill evidence gap distribution dynamics other

Language: Английский

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Assessment of COVID-19 vaccination among healthcare workers in Iraq; adverse effects and hesitancy

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(11), P. e0274526 - e0274526

Published: Nov. 18, 2022

Several messenger ribonucleic acid (mRNA) and inactivated COVID-19 vaccines are available to the global population as of 2022. The acceptance vaccine will play a key role in combating worldwide pandemic. Public confidence this is largely based on its safety effectiveness. This study was designed provide independent evidence adverse effects associated with among healthcare workers Iraq identify attitudes who rejected vaccination. We conducted cross-sectional collect data Pfizer, AstraZeneca, Sinopharm vaccines. Data were collected between October 2021 February A total 2,202 participants enrolled study: (89.97%) received injections (10.03%) hesitant receive Participants either Pfizer (62.9%), AstraZeneca (23.5%) or (13.6%). Most significantly less prevalent second dose than first dose. Notably, more females males. Following dose, experienced vaccine. Interestingly, prevalence infection two doses reduced compared those According vaccine-hesitated participants, insufficient knowledge (29.9%), expeditious development (27.6%) lack trust (27.1%) three major reasons for refusing results our indicated that these do not present significant problem should prevent successful control

Language: Английский

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Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects

Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 640 - 640

Published: June 9, 2023

Viruses are widespread in the environment, and many of them major pathogens serious plant, animal, human diseases. The risk pathogenicity, together with capacity for constant mutation, emphasizes need measures to rapidly detect viruses. highly sensitive bioanalytical methods diagnose monitor socially significant viral diseases has increased past few years. This is due, on one hand, incidence general (including unprecedented spread a new coronavirus infection, SARS-CoV-2), and, other overcome limitations modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used sensor-based virus detection. review analyzes commonly detection approaches shows prospects use prepared by phage sensing elements

Language: Английский

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Ce-based solid-phase catalysts for phosphate hydrolysis as new tools for next-generation nanoarchitectonics

Science and Technology of Advanced Materials, Journal Year: 2023, Volume and Issue: 24(1)

Published: Aug. 24, 2023

This review comprehensively covers synthetic catalysts for the hydrolysis of biorelevant phosphates and pyrophosphates, which bridge between nanoarchitectonics biology to construct their interdisciplinary hybrids. In early 1980s, remarkable catalytic activity Ce4+ ion phosphate was found. More recently, this finding has been extended Ce-based solid (CeO2 metal-organic frameworks (MOFs)), are directly compatible with nanoarchitectonics. Monoesters triesters phosphates, as well were effectively cleaved by these catalysts. With use either CeO2 nanoparticles or elegantly designed MOF, highly stable phosphodiester linkages also hydrolyzed. On surfaces all catalysts, Ce3+ coexist cooperate catalysis. The activates substrates a strong acid, whereas provides metal-bound hydroxide an eminent nucleophile. Applications practical purposes discussed.

Language: Английский

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COVID-19 antibody responses in individuals with natural immunity and with vaccination-induced immunity: a systematic review and meta-analysis

Systematic Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 19, 2024

Abstract Background The COVID-19 pandemic has caused a large mortality and morbidity burden globally. For individuals, strong immune response is the most effective means to block SARS-CoV-2 infection. To inform clinical case management of COVID-19, development improved vaccines, public health policy, better understanding antibody dynamics duration following infection after vaccination imperatively needed. Methods We systematically analyzed rates in naturally infected patients vaccinated individuals. Specifically, we searched all published pre-published literature between 1 December 2019 31 July 2023 using MeSH terms “all field” comprising “COVID-19” or “SARS-CoV-2,” “antibody response” “immunity “humoral immune.” included experimental observational studies that provided positivity natural vaccination. A total 44 reporting rate changes over time were included. Results meta-analysis showed within first week symptom onset/diagnosis vaccination, individuals lower than those ( p < 0.01), but no significant difference was observed from second sixth month. IgG, IgA, IgM increased during 3 weeks; thereafter, IgG maintained at relatively high level, while seroconversion dropped. Conclusions Antibody production might not occur as quickly strongly infection, less persistent response.

Language: Английский

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Continuous care needs in patients with cancer receiving chemotherapy during the recent omicron wave of COVID-19 in Shanghai: A qualitative study

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

This study aimed to investigate the care needs, clarify factors affecting quality of homecare, and provide reference for constructing a homecare system patients with cancer receiving chemotherapy during recent omicron wave COVID-19 in Shanghai.From March May 2022 when emerged Shanghai, 50 consecutive who received at Ruijin Hospital, Shanghai Jiao Tong University School Medicine, were enrolled, underwent face-to-face or telephone-based semi-structured interviews regarding continuous needs. Some their homecare-givers, caring nurses, physicians also interviewed. The Colaizzi method was used data analysis.Fifty patients, 4 Three themes six subthemes from analysis interviews: first theme "Disease management needs," including needs knowledge managing adverse events associated chemotherapy, treatment-related information. Patients expressed most concern about not being able go hospital blood review disease evaluation time due outbreak. With pandemic ongoing, such as panic, inconvenient medical treatment, worry cross-infection might reduce cancer. second "Medical mobile healthcare resources. All interviewees emphasized importance pandemic, access hospitals difficult. third "Spiritual demands psychological counseling intervention, spiritual care. homecare-givers commonly lacked feeling security needed communication, encouragement, reassurance that could be delivered them, reported they very much wanted advice.For is greatly needed. Medical personnel should strengthen education caregivers hospitalization, further improve patients' information intake rate through Internet-based digital methods meet after discharge hospital.

Language: Английский

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Manipulation, Sampling and Inactivation of the SARS-CoV-2 Virus Using Nonuniform Electric Fields on Micro-Fabricated Platforms: A Review

Micromachines, Journal Year: 2023, Volume and Issue: 14(2), P. 345 - 345

Published: Jan. 29, 2023

Micro-devices that use electric fields to trap, analyze and inactivate micro-organisms vary in concept, design application. The application of manipulate bacteria single-celled organisms has been described extensively the literature. By contrast, effect such on viruses is not well understood. This review explores possibility using existing methods for manipulating inactivating larger bacteria, smaller viruses, as SARS-CoV-2. It also provides an overview theoretical background. findings may be used implement new ideas frame experimental parameters optimize manipulation, sampling inactivation SARS-CoV-2 electrically.

Language: Английский

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Blood Biomarkers from the Emergency Department Disclose Severe Omicron COVID-19-Associated Outcomes

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 925 - 925

Published: April 2, 2023

Since its outbreak, Coronavirus disease 2019 (COVID-19), a life-threatening respiratory illness, has rapidly become public health emergency with devastating social impact. Lately, the Omicron strain is considered main variant of concern. Routine blood biomarkers are, indeed, essential for stratifying patients at risk severe outcomes, and huge amount data available in literature, mainly previous variants. However, only few studies are on early routine biochemical Omicron-afflicted patients. Thus, aim novelty this study were to identify detected room prediction morbidity and/or mortality.449 COVID-19 from Sapienza University Hospital Rome divided into four groups: (1) group (patients mild forms who quickly discharged); (2) hospital ward that after admission department hospitalized ward); (3) intensive care unit (ICU) required assistance); (4) deceased had fatal outcome).ANOVA ROC showed high-sensitivity troponin-T (TnT), fibrinogen, glycemia, C-reactive protein, lactate dehydrogenase, albumin, D-dimer myoglobin, ferritin both men women may predict lethal outcomes already level department.Compared Delta parallel patterns prediction, Omicron-induced changes TnT be other predictors outcomes.

Language: Английский

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COVID-19 impacts and inequities among underserved communities with diabetes

Journal of Clinical & Translational Endocrinology, Journal Year: 2024, Volume and Issue: 36, P. 100337 - 100337

Published: March 19, 2024

People with diabetes have higher COVID-19 morbidity and mortality. These risks are amplified for underserved communities including racial/ethnic minorities people lower socioeconomic status. However, limited research has examined outcomes specifically affecting diabetes. From November 2021 to July 2022, adults insulin-requiring at federally qualified health centers in Florida California (n = 450) completed surveys examining demographics. Surveys assessed severity, vaccination uptake, mask-wearing habits, income changes, healthcare access changes. also included the full Coronavirus Anxiety Scale (CAS-19). Descriptive statistics were computed all outcomes. Between-group comparisons state race/ethnicity evaluated via Chi-Squared, Fisher's Exact, Cochran-Mantel-Haenszel, One-Way ANOVA, t-tests. Logistic regression determined factors associated uptake. Data self-reported analyzed cross-sectionally. Overall, 29.7 % reported contracting COVID-19; of those, 45.3 sought care or hospitalized. Most (81.3 %) received ≥ 1 vaccine. Hispanics had highest rate (91.1 %); Non-Hispanic Blacks (NHBs) lowest (73.9 %; p =.0281). 4.63x greater odds than Whites ([NHWs]; 95 CI [1.81, 11.89]). NHWs least often wore masks (18.8 <.001). Participants pandemic-related changes (62 costs medications (41 %). Income loss was more frequent (76 NHBs most frequently "severe" (26.4 =.0124). Loss insurance common among (13.3 =.0416) (9.7 =.039). anxiety (IQR [0.0, 3.0]; =.0232) 2.0]; =.0435). Underserved high vaccine uptake but experienced significant COVID-19-related physical, psychosocial, financial impacts. those worse other groups California. Further research, interventions, policy needed promote equity this population.

Language: Английский

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