Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 10, 2024
Abstract
Vascular
calcification
(VC)
is
a
common
complication
of
chronic
kidney
disease
(CKD)
that
has
detrimental
effect
on
patients'
survival
and
prognosis.
The
aim
this
study
was
to
develop
validate
practical
reliable
prediction
model
for
VC
in
CKD5
patients.
medical
records
544
patients
were
reviewed
retrospectively.
Multivariate
logistic
regression
analysis
used
identify
the
independent
risk
factors
vascular
with
then
created
nomogram
model.
area
under
receiver
operating
characteristic
curve
(AUC),
Hosmer–Lemeshow
test,
decision
(DCA)
assess
performance.
split
into
groups
normal
high
serum
uric
acid
levels,
influencing
these
levels
investigated.
Age,
BUN,
SUA,
P
TG
modeling
group
(
<
0.05).
In
internal
validation,
results
showed
AUC
0.917.
No
significant
divergence
between
predicted
probability
actual
incidence
rate
(x
2
=
5.406,
0.753)
revealed
by
calibration
plot
HL
thus
confirming
satisfactory.
external
validation
also
good
discrimination
(AUC
0.973).
chart
test
demonstrated
consistency.
Besides,
correlation
all
elevated
may
be
related
gender,
P,
TG.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Jan. 3, 2023
Abstract
Vascular
calcification
(VC)
is
recognized
as
a
pathological
vascular
disorder
associated
with
various
diseases,
such
atherosclerosis,
hypertension,
aortic
valve
stenosis,
coronary
artery
disease,
diabetes
mellitus,
well
chronic
kidney
disease.
Therefore,
it
life‐threatening
state
for
human
health.
There
were
several
studies
targeting
mechanisms
of
VC
that
revealed
the
importance
smooth
muscle
cells
transdifferentiating,
phosphorous
and
calcium
milieu,
matrix
vesicles
on
progress
VC.
However,
underlying
molecular
need
to
be
elucidated.
Though
there
no
acknowledged
effective
therapeutic
strategy
reverse
or
cure
clinically,
recent
evidence
has
proved
not
passive
irreversible
comorbidity
but
an
active
process
regulated
by
many
factors.
Some
available
approaches
mechanism
provide
promising
prospects
therapy
This
review
aims
summarize
novel
findings
interventions
VC,
including
role
inflammatory
responses,
endoplasmic
reticulum
stress,
mitochondrial
dysfunction,
iron
homeostasis,
metabolic
imbalance,
some
related
signaling
pathways
progression.
We
also
conclude
controversial
in
clinical
practice
channel
blockers,
renin–angiotensin
system
inhibitions,
statins,
bisphosphonates,
denosumab,
vitamins,
ion
conditioning
agents.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(3), P. 457 - 457
Published: March 21, 2023
Atherosclerosis
is
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
lipids
in
vessel
wall,
leading
to
formation
an
atheroma
and
eventually
development
vascular
calcification
(VC).
Lipoproteins
play
central
role
atherosclerosis
VC.
Both
low-
very
low-density
lipoproteins
(LDL
VLDL)
lipoprotein
(a)
(Lp(a))
stimulate,
while
high-density
(HDL)
reduce
Apolipoproteins,
protein
component
lipoproteins,
influence
VC
multiple
ways.
Apolipoprotein
AI
(apoAI),
main
HDL,
has
anti-calcific
properties,
apoB
apoCIII,
components
LDL
VLDL,
respectively,
promote
The
also
related
their
metabolism
modifications.
Oxidized
(OxLDL)
are
more
pro-calcific
than
native
LDL.
Oxidation
converts
HDL
from
anti-
pro-calcific.
Additionally,
enzymes
such
as
autotaxin
(ATX)
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9),
involved
metabolism,
have
stimulatory
In
summary,
better
understanding
mechanisms
which
apolipoproteins
contribute
will
be
crucial
effective
preventive
therapeutic
strategies
for
its
associated
cardiovascular
disease.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(2), P. 306 - 306
Published: Feb. 19, 2023
The
age-old
axiom
that
one
is
as
old
his
or
her
vessels
are,
calls
for
ongoing
critical
re-examination
of
modifiable
risk
factors
accelerated
vascular
ageing
in
chronic
kidney
diseases.
Attempts
to
modulate
with
cholesterol-lowering
agents
have
largely
failed
advanced
disease
(CKD).
In
addition
nitrogen
waste
products,
many
pathological
biochemical
processes
also
play
a
role
calcification
damage.
Magnesium,
cation
vital
the
body,
may
substantially
reduce
cardiovascular
diseases’
and
progression.
This
narrative
review
aimed
address
relationship
between
hypomagnesemia
calcification,
which
promotes
further
complications
diabetes,
aging,
CKD.
Articles
predefined
keywords
were
searched
PubMed
Google
Scholar
databases
specific
inclusion
exclusion
criteria.
We
hypothesized
decrease
serum
magnesium
levels
contributes
increased
thereby
increases
mortality.
summary,
based
on
existing
evidence
literature,
it
appears
simple
inexpensive
oral
supplementation
mortality
patients
who
are
already
severely
affected
by
such
diseases;
this
context,
concept
‘normal’
vs.
‘ideal’
should
be
carefully
re-examined.
Reviews in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
25(2), P. 51 - 51
Published: Jan. 30, 2024
Vascular
calcification
(VC)
is
a
complex
process
of
calcium
deposition
on
the
arterial
wall
and
atherosclerotic
plaques
involves
interaction
between
vascular
smooth
muscle
cells,
inflammatory
VC
mediators.
The
latter
are
independent
predictors
cardiovascular
morbidity
mortality
potential
targets
pharmaceutical
therapy.
This
paper
narrative
review
mechanisms
development
in
this
context
anti-atherosclerotic
effects
statins.
At
initial
stages
atherosclerosis
correlates
with
burden
long-term
mortality.
A
plethora
animal
clinical
studies
have
proposed
statins
as
cornerstone
primary
secondary
prevention
disease.
Based
coronary
computed
tomography
data,
high
doses
may
negligible
or
even
positive
progression
artery
calcification.
Growing
data
support
an
increase
plaque
peripheral
arteries
(e.g.,
carotids),
after
long-term,
statin-therapy.
Despite
paradox
increasing
VC,
those
been
associated
higher
stability,
reducing
risk
consequent
adverse
events.
Statins
seem
to
promote
"favorable"
calcification,
suppressing
lesion
expansion
their
vulnerability.
More
required
clarify
underlying
mechanisms.
Renal Failure,
Journal Year:
2024,
Volume and Issue:
46(2)
Published: June 14, 2024
Introduction
The
Agatston
coronary
artery
calcification
score
(CACS)
is
an
assessment
index
for
(CAC).
This
study
aims
to
explore
the
characteristics
of
CAC
in
end-stage
kidney
disease
(ESKD)
patients
and
establish
a
predictive
model
assess
risk
severe
patients.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(2), P. 861 - 878
Published: Jan. 1, 2024
Rationale:
Vascular
calcification
(VC)
is
a
life-threatening
complication
in
patients
with
chronic
kidney
disease
(CKD)
caused
mainly
by
hyperphosphatemia.However,
the
regulation
of
VC
remains
unclear
despite
extensive
research.Although
serum-and
glucocorticoid-induced
kinase
3
(SGK3)
regulate
sodium-dependent
phosphate
cotransporters
intestine
and
kidney,
its
effect
on
CKD
unknown.Additionally,
type
III
cotransporter-1
(Pit-1)
plays
significant
role
development
induced
high
vascular
smooth
muscle
cells
(VSMCs).However,
it
whether
SGK3
regulates
Pit-1
how
exactly
promotes
via
at
molecular
level.Thus,
we
investigated
certified
outflow
vein
arteriovenous
fistulas
(AVF)
aortas
uremic
mice.Methods
Results:
In
our
study,
using
mice,
observed
upregulation
calcium
deposition
veins
AVF
aortas,
increase
expression
was
positively
correlated
aortas.In
vitro,
downregulation
reversed
VSMCs
phenotype
switching
phosphate.Mechanistically,
activation
enhanced
mRNA
transcription
through
NF-κB,
downregulated
ubiquitin-proteasome
mediated
degradation
inhibiting
activity
neural
precursor
expressing
developmentally
protein
4
subtype
2
(Nedd4-2),
an
E3
ubiquitin
ligase.Moreover,
under
stimulation,
uptake
independent
increased
Pit-1.Our
co-immunoprecipitation
vitro
assays
confirmed
that
interacts
Thr468
loop7,
leading
to
uptake.Conclusion:
Thus,
justifiable
conclude
enhancing
activities
Pit-1,
which
indicate
could
be
therapeutic
target
for
CKD.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 20, 2025
Background
Abdominal
aortic
calcification
(AAC)
is
prevalent
among
middle-aged
and
elderly
populations,
elevating
the
risk
of
cardiovascular
cerebrovascular
events.
Leveraging
data
from
National
Health
Nutrition
Examination
Survey
(NHANES),
we
conducted
a
nationally
representative
cross-sectional
study.
Our
aim
was
to
evaluate
whether
subjective
interventions
could
influence
AAC
scores
by
modifying
antioxidant/pro-oxidant
status
individuals
investigate
role
glycohemoglobin
in
this
relationship.
Methods
The
study
analyzed
1,600
U.S.
adults.
used
oxidation
balance
score
(OBS)
as
an
exposure
variable
derived
16
dietary
4
lifestyle
factors,
well
obtained
blood
tests.
main
outcome
measure
AAC,
which
evaluated
dual-energy
X-ray
absorption
quantified
Kauppila
scoring
system.
Results
mean
(SD)
age
patients
56.53
(10.90)
years,
with
female
predominance
(50.22%).
According
weighted
linear
regressions
not
adjusted
for
covariates,
were
lower
third
fourth
quartile
groups
OBS
than
first
group
(Q3:
coefficients
[coef],
−0.92
[95%
CI,
−1.64
to-0.20],
p
=
0.017;
Q4:
−0.97
−1.86
~
−0.08;
<
0.035]).
regression
subgroup
analyses,
there
no
significant
OBS-AAC
correlations
males
(
>
0.05),
but
females
0.05).
Smooth
fitting
curves
showed
more
trend
change
negative
correlation
between
postmenopausal
women
premenopausal
women.
In
further
mediation
identified
mediator
relationship
oxidative
AAC.
Conclusion
This
revealed
scores,
particularly
partly
mediated
glycohemoglobin.
Renal Failure,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: Jan. 26, 2025
Vascular
calcification
is
common
and
progressive
in
patients
with
chronic
kidney
disease.
However,
the
risk
factors
associated
progression
of
vascular
receiving
maintenance
dialysis
have
not
been
fully
elucidated.
Here,
we
aimed
to
evaluate
identify
its
hemodialysis.
This
a
prospective
longitudinal
study
that
included
374
The
participants
received
assessments
coronary
artery
(CAC)
abdominal
aortic
(AAC),
as
measured
by
computed
tomography.
After
baseline
investigation,
2
years
follow-up
was
performed.
We
also
detected
markers
endothelial
injury
[E-selectin
soluble
intercellular
adhesion
molecule-1
(sICAM-1)].
Finally,
affecting
CAC
AAC
were
examined
multivariate
logistic
regression
analysis.
Among
patients,
median
[interquartile
range
(IQR)]
age
54.0
(40.0-62.0)
years;
59.9%
male.
(IQR)
time
1.9
(1.8-2.0)
for
all
patients.
By
end
2-year
follow-up,
(including
AAC)
observed
58.0%
Further,
compared
without
calcification,
E-selectin
sICAM-1)
markedly
enhanced.
Moreover,
after
adjustment
confounders,
factor
calcification.
present
indicated
one
Preventive Medicine Reports,
Journal Year:
2025,
Volume and Issue:
51, P. 102994 - 102994
Published: Feb. 1, 2025
Background
and
Objective:
Abdominal
aortic
calcification
(AAC)
is
a
marker
of
cardiovascular
disease
associated
with
increased
mortality
in
middle-aged
older
populations.
However,
its
relationship
frailty
remains
unclear.
Methods:
Data
were
obtained
from
the
2013-2014
National
Health
Nutrition
Examination
Survey.
AAC
was
quantified
using
Kauppila
scoring
system
based
on
dual-energy
X-ray
absorptiometry.
Frailty
assessed
index.
Multivariable
logistic
regression
models
examined
association
between
frailty.
Results:
A
total
2987
adults
aged
≥40
years
included.
Compared
to
individuals
an
AAC-8
score
0,
low-risk
(AAC-8
=
1-2;
OR:
1.24;
95
%
CI,
1.00-1.53)
high-risk
≥
3;
1.83;
1.03-3.23)
higher
odds
Similarly,
mild
moderate
(0
<
AAC-24
≤
6;
1.26;
1.03-1.54)
severe
(AAC-24
>
1.79;
1.07-2.99)
showed
positive
associations
Conclusions:
Among
populations
United
States,
there
exists
correlation
Our
findings
suggest
that
holds
promise
as
valuable
tool
for
early
identification