Russian Open Medical Journal,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: March 31, 2025
Background
—
Studying
the
lipidome
and,
in
particular,
mobile
pool
of
fatty
acids
(FA)
can
provide
more
detailed
information
about
development
and
maintenance
excess
body
fat,
which
makes
this
scientific
direction
promising.
The
goal
study
was
to
investigate
characteristics
FA,
including
membrane
indices
adolescents
with
different
weights.
Methods
included
75
aged
10
17
years.
main
group
(n=45)
Grade
1
2
alimentary
obesity.
control
comprised
30
healthy
adolescents.
groups
were
divided
into
subgroups
based
on
gender.
Anthropometric
assessment
measuring
height
weight.
FA
(lipoproteins
free
acids,
FFA)
blood
serum
analyzed
an
Agilent
7000B
chromatography
mass
spectrometry
device.
Results
Among
boys,
a
number
demonstrated
statistically
significant
changes,
e.g.,
whole
ω-3
index
(1.335
[1.230;
1.540]
%
FA)
erythrocyte
(1.620
[1.520;
1.813]
FA).
ω-6/ω-3
ratio
presence
obesity
(13.310
[11.400;
16.705]
exceeded
upper
limit
laboratory
reference
range
(2.90-13.06%
boys.
subintimal
inflammatory
response
risk
elevated
both
groups,
but
significantly
higher
among
normal
weight
(51.320
[38.368;
57.260]
81.450
[63.120;
210.860]
respectively).
polyunsaturated/saturated
levels
0.400
[0.375;
0.558]
0.740
[0.630;
0.990]
respectively.
girls,
changes:
(%
saturated
obese
showed
level
1.680
[1.365;
1.910]
ω-6
also
reduction
(21.050
[19.130;
23.100]
Levels
polyunsaturated
total
lower
vs.
values
(36.67-47.73%
FA):
22.380
[20.790;
24.990]
35.460
[30.290;
42.950]
Saturated
threshold
(34.09-40.74%
groups:
55.240
[52.470;
56.185]
45.900
[38.160;
50.290]
exhibited
increase
(even
latter):
57.090
[49.290;
82.385]
136.990
[0.390;
0.485]
0.810
1.160]
Conclusion
All
examined
children
(whole
index,
cell
viscosity,
fluidity
permeability
index)
changes
These
associated
not
only
increased
cardiovascular
progression
chronic
inflammation,
nature
children’s
growth
development.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2433 - 2433
Published: March 8, 2025
Alzheimer’s
disease
(AD)
is
an
increasing
global
healthcare
crisis
with
few
effective
treatments.
The
accumulation
of
amyloid
plaques
and
hyper-phosphorylated
tau
are
thought
to
underlie
the
pathogenesis
AD.
However,
current
studies
have
recognized
a
prominent
role
cerebrovascular
dysfunction
in
We
recently
reported
that
SNPs
soluble
epoxide
hydrolase
(sEH)
linked
AD
human
genetic
long-term
administration
sEH
inhibitor
attenuated
cerebral
vascular
cognitive
rat
model
mechanisms
linking
changes
function
neuroprotective
actions
inhibitors
remain
be
determined.
This
study
investigated
effects
inhibitor,
1-(1-Propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
(TPPU),
on
neurovascular
coupling,
blood–brain
barrier
(BBB)
function,
neuroinflammation,
hAPP/PS1
TgF344-AD
observed
predominant
β-amyloid
brains
9–10-month-old
rats
TPPU
treatment
for
three
months
reduced
burden.
functional
hyperemic
response
whisker
stimulation
was
rats,
normalized
response.
TPPU,
mitigated
capillary
rarefaction,
BBB
leakage,
activation
astrocytes
microglia
rats.
increased
expression
pre-
post-synaptic
proteins
loss
hippocampal
neurons
impairments
which
confirmed
transcriptome
GO
analysis.
These
results
suggest
could
novel
therapeutic
strategy
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 12, 2025
Abstract
Background
Osteosarcoma
is
a
rare
tumor
with
poor
clinical
outcomes.
New
therapeutic
targets
are
urgently
needed.
Previous
research
indicates
that
genes
abnormally
expressed
in
osteosarcoma
significantly
involved
the
arachidonic
acid
(AA)
metabolic
pathway.
However,
role
of
metabolism-related
(AAMRGs)
prognosis
remains
unknown.
Methods
samples
from
The
Cancer
Genome
Atlas
(TCGA)
and
Gene
Expression
Omnibus
(GEO)
databases
were
classified
into
high-score
low-score
groups
based
on
AAMRGs
scores
obtained
through
ssGSEA
analysis.
intersecting
identified
weighted
gene
co-expression
network
analysis
(WGCNA),
DEGs
(osteosarcoma
vs.
normal)
DE-AAMRGs
(high-
low-score).
An
AA
metabolism
predictive
model
five
established
by
Cox
regression
LASSO
algorithm.
Model
performance
was
evaluated
using
Kaplan-Meier
survival
receiver
operating
characteristic
(ROC)
curve
In
vitro
experiments
related
biomarkers
validated.
Results
Our
study
constructed
an
prognostic
signature
(CD36,
CLDN11,
STOM,
EPYC,
PANX3).
K-M
indicated
patients
low-risk
group
showed
superior
overall
to
high-risk
(
p
<0.05).
ROC
curves
all
AUC
values
exceeded
0.76.
By
ESTIMATE
algorithms,
we
discovered
had
lower
immune
score,
stromal
estimate
score.
Correlation
strongest
positive
correlation
between
STOM
natural
killer
cells,
highest
negative
association
PANX3
central
memory
CD8
T
cells.
for
prognosis.
Conclusion
suggested
high
level
might
serve
as
biomarker
offers
potential
explanation
cyclooxygenase
inhibitors
cancer.
PANX3,
STOM)
screened
construct
risk
value,
providing
new
reference
treatment
osteosarcoma.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3114 - 3114
Published: March 28, 2025
The
inflammatory
state
is
a
significant
factor
associated
with
diabetic
kidney
disease
(DKD),
making
it
one
of
the
causes
chronic
disease.
Despite
availability
data,
there
lack
targeted
treatment
strategies
for
diabetes-related
disorders.
aim
our
study
was
to
determine
impact
cannabigerol
(CBG)
on
lipid
precursors
mediators
during
DKD
development.
A
six-week
experiment
conducted
male
Wistar
rats
fed
standard
(Control)
or
high-fat
high-sucrose
(HFHS)
diets.
For
last
14
days
(5th
and
6th
weeks),
half
from
Control
HFHS
groups
intragastrically
received
CBG
solution.
Gas-liquid
chromatography
(GLC)
used
measure
activities
n-6
n-3
polyunsaturated
fatty
acid
(PUFA)
metabolic
pathways
concentrations
arachidonic
(AA),
eicosapentaenoic
(EPA),
docosahexaenoic
(DHA)
in
selected
fractions.
Immunoblotting
performed
assess
expression
proteins
involved
regulation
state.
multiplex
immunoassay
kit
toxicity
biomarker
levels.
Our
results
revealed
that
administration
an
diet
decreased
PUFA
biosynthetic
pathway
activity
phospholipid
(PL)
triacylglycerol
(TAG)
increased
TAG
free
(FFA).
We
also
observed
reduction
AA
concentration
PL,
FFA,
diacylglycerol
(DAG).
supplementation
reduced
level
damage
biomarkers,
such
as
osteopontin
(OPN).
observations
confirm
has
potential
anti-inflammatory
properties
may
be
successfully
further
research
seek
therapies
disorders,
including
progression.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 508 - 508
Published: March 31, 2025
Upper
gastrointestinal
bleeding
from
erosive
gastritis
remains
associated
with
high
mortality
in
septic
or
postoperative
patients.
While
stress
ulcer
has
declined,
it
still
occurs
patients
and
is
considered
a
manifestation
of
intestinal
failure
within
multi-organ
syndrome.
The
integrity
the
gastric
mucosal
barrier
plays
crucial
role
protection
against
this
condition.
Somatostatin
(SS)
appears
as
biomolecule
cytoprotective
properties.
We
aimed
to
investigate
whether
SS
treatment
protected
mucosa
rat
model
lipopolysaccharide
(LPS)-induced
sepsis.
Rats
received
LPS
(10
mg/kg)
intraperitoneally,
followed
by
saline
(200
μg/kg;
5
mL/kg)
after
30
min
(early
group)
120
(late
group).
Control
rats
only
saline.
Two
hours
administration
(total
procedure
duration
150
240
min),
lavage,
mucosa,
plasma
samples
were
collected
for
analysis.
mitigated
LPS-induced
disruption
preserving
phosphatidylcholine
(PC)
levels,
well
decreasing
leukocyte
infiltration
marker
myeloperoxidase
(MPO),
inflammation-related
enzyme
phospholipase
A2
(PLA2),
lipid
peroxidation
indicator
malondialdehyde
(MDA).
also
reduced
arachidonic
acid-related
metabolites
thromboxane
B2
(TXB2)
leukotriene
B4
(LTB4)
while
increasing
prostaglandin
I2
(PGI2).
effectively
maintained
integrity,
reducing
inflammation,
modulating
acid
metabolites.
These
findings
suggest
that
may
serve
therapeutic
agent
inflammation
injury.
Russian Open Medical Journal,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: March 31, 2025
Background
—
Studying
the
lipidome
and,
in
particular,
mobile
pool
of
fatty
acids
(FA)
can
provide
more
detailed
information
about
development
and
maintenance
excess
body
fat,
which
makes
this
scientific
direction
promising.
The
goal
study
was
to
investigate
characteristics
FA,
including
membrane
indices
adolescents
with
different
weights.
Methods
included
75
aged
10
17
years.
main
group
(n=45)
Grade
1
2
alimentary
obesity.
control
comprised
30
healthy
adolescents.
groups
were
divided
into
subgroups
based
on
gender.
Anthropometric
assessment
measuring
height
weight.
FA
(lipoproteins
free
acids,
FFA)
blood
serum
analyzed
an
Agilent
7000B
chromatography
mass
spectrometry
device.
Results
Among
boys,
a
number
demonstrated
statistically
significant
changes,
e.g.,
whole
ω-3
index
(1.335
[1.230;
1.540]
%
FA)
erythrocyte
(1.620
[1.520;
1.813]
FA).
ω-6/ω-3
ratio
presence
obesity
(13.310
[11.400;
16.705]
exceeded
upper
limit
laboratory
reference
range
(2.90-13.06%
boys.
subintimal
inflammatory
response
risk
elevated
both
groups,
but
significantly
higher
among
normal
weight
(51.320
[38.368;
57.260]
81.450
[63.120;
210.860]
respectively).
polyunsaturated/saturated
levels
0.400
[0.375;
0.558]
0.740
[0.630;
0.990]
respectively.
girls,
changes:
(%
saturated
obese
showed
level
1.680
[1.365;
1.910]
ω-6
also
reduction
(21.050
[19.130;
23.100]
Levels
polyunsaturated
total
lower
vs.
values
(36.67-47.73%
FA):
22.380
[20.790;
24.990]
35.460
[30.290;
42.950]
Saturated
threshold
(34.09-40.74%
groups:
55.240
[52.470;
56.185]
45.900
[38.160;
50.290]
exhibited
increase
(even
latter):
57.090
[49.290;
82.385]
136.990
[0.390;
0.485]
0.810
1.160]
Conclusion
All
examined
children
(whole
index,
cell
viscosity,
fluidity
permeability
index)
changes
These
associated
not
only
increased
cardiovascular
progression
chronic
inflammation,
nature
children’s
growth
development.
