Asian Pacific Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: 25(7), P. 2319 - 2327
Published: July 1, 2024
Prostate cancer is the most common tumor in men worldwide with a poor prognosis. In recent years, studies have revealed that pyroptosis can affect immune microenvironment. However, relationship between microenvironment regulated by pyroptosis-related genes and prognosis of prostate still unclear.
Language: Английский
MedComm, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 1, 2025
Abstract Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well the scarcity of cancer‐specific antigens. Therefore, enrichment tumor‐antigen specific CAR‐T desired region is critical for improving therapy efficacy reducing systemic on‐target/off‐tumor side effects. Here, we functionalized human with superparamagnetic iron oxide nanoparticles (SPIONs), making them magnetically controllable site‐directed targeting. SPION‐loaded maintained their cytolytic capacity melanoma expressing CAR‐specific chondroitin sulfate proteoglycan (CSPG4). Importantly, SPIONs suppressed cytokine release loaded cells, shifting cell death phenotype from pyroptosis apoptosis. Furthermore, could be enriched a dynamic flow model through an external magnetic field detected MRI. These results demonstrate that lytic cytotoxicity retained after SPION‐functionalization provides basis future site‐specific immunotherapies reduced adverse
Language: Английский
Citations
2
MedComm, Journal Year: 2024, Volume and Issue: 5(9)
Published: Sept. 1, 2024
Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.
Language: Английский
Citations
14
MedComm, Journal Year: 2023, Volume and Issue: 4(5)
Published: Sept. 24, 2023
Abstract Nonprogrammed cell death (NPCD) and programmed (PCD) are two types of death. Cell is significantly linked to tumor development, medication resistance, cancer recurrence, metastatic dissemination. Therefore, a comprehensive understanding essential for the treatment cancer. Pyroptosis kind PCD distinct from autophagy apoptosis in terms structure function cells. The defining features pyroptosis include release an inflammatory cascade reaction expulsion lysosomes, mediators, other cellular substances within cell. Additionally, it displays variations osmotic pressure both outside Pyroptosis, as evidenced by growing body research, critical controlling development diseases In this paper, we reviewed current level knowledge on mechanism inflammasomes their connection diseases. This article presents theoretical framework investigating potential therapeutic targets diseases, overcoming establishing nanomedicines associated with pyroptosis, developing risk prediction models refractory Given link between emergence pyroptosis‐targeted treatments may be cutting‐edge strategy.
Language: Английский
Citations
19
Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 346 - 346
Published: Feb. 16, 2024
Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity. Although has achieved remarkable clinical success for some patients, many patients do not respond, underscoring need develop new strategies promote Pyroptosis an immunostimulatory type regulated cell death activates innate system. A hallmark pyroptosis release intracellular contents such as cytokines, alarmins, chemokines can stimulate adaptive activation. Recent studies suggest promotes Here, we review mechanisms by which be induced highlight induce cells defense. We discuss how modulates tumor microenvironment immunity also research areas focus on continued development anticancer treatment. Pyroptosis-based therapies offer promising avenue treating immunologically 'cold' tumors.
Language: Английский
Citations
8
Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
Language: Английский
Citations
8
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444
Published: Aug. 1, 2024
Language: Английский
Citations
4
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: March 1, 2025
Neutrophil extracellular traps (NETs) are unique fibrous structures released by neutrophils in response to various pathogens, exhibiting both anti-inflammatory and proinflammatory effects. In autoimmune conditions, NETs serve as crucial self-antigens triggering inflammatory cascades activating the inflammasome complement systems, disrupting self-tolerance mechanisms accelerating responses. Furthermore, play a pivotal role modulating immune cell activation, affecting adaptive This review outlines intricate relationship between diseases, including arthritis, systemic Behçet's disease, lupus erythematosus, kidney skin sclerosis, vasculitis, gouty arthritis. It highlights potential of targeting therapeutic strategy diseases. By examining dynamic balance NET formation clearance this offers critical insights theoretical foundation for future research on NET-related mechanisms. Advances systems biology, flow cytometry, single-cell multiomics sequencing have provided valuable tools exploring molecular NETs. These advancements renewed focus offering promising avenues further investigation into their clinical implications.
Language: Английский
Citations
0
Placenta, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 364 - 373
Published: May 7, 2025
Tanshinone IIA (Tan IIA), a bioactive compound derived from the traditional Chinese herb Salvia miltiorrhiza (Family Lamiaceae, Authority Bunge), is well-known for its protective effects in various kidney diseases. However, role obstructive nephropathy has not been thoroughly investigated. This study aimed to explore of Tan mouse model unilateral ureteral obstruction (UUO) and elucidate cellular molecular mechanisms underlying these effects. Gasdermin D (GSDMD) knockout mice their wild-type (WT) littermates underwent UUO surgery, with treatment administered 24 h prior. Human proximal tubular cells (HK-2 cells) were treated TGF-β1 induce fibrosis (50 ng/mL h), followed by (5 μM) an additional 3 h. significantly reduced expression extracellular matrix (ECM) components, including collagen I, α-smooth muscle actin (α-SMA), vimentin fibronectin, mice. attenuated GSDMD-mediated pyroptosis. GSDMD subjected UUO, on ECM gene deposition interstitium reduced. In vitro studies showed that activation fibronectin protein HK-2 cells. may mitigate pyroptosis renal epithelial (RTECs) reduce fibrosis, highlighting potential as therapeutic strategy prevent progression disease after obstruction.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4783 - 4783
Published: April 27, 2024
Alterations in cellular signaling, chronic inflammation, and tissue remodeling contribute to hepatocellular carcinoma (HCC) development. The release of damage-associated molecular patterns (DAMPs) upon injury the ensuing sterile inflammation have also been attributed a role HCC pathogenesis. Cargoes extracellular vesicles (EVs) and/or EVs themselves listed among circulating DAMPs but only partially investigated HCC. Mitochondria-derived (MDVs), subpopulation EVs, are another missing link comprehension mechanisms underlying onset progression biology. involved growth, dissemination, angiogenesis, immunosurveillance escape. contribution MDVs these processes is presently unclear. Pyroptosis triggers systemic through caspase-dependent apoptotic cell death implicated tumor immunity. analysis this process, together with MDV characterization, may help capture relationship development, mitochondrial quality control, inflammation. combination immune checkpoint inhibitors (i.e., atezolizumab bevacizumab) has approved as synergistic first-line treatment for unresectable or advanced lack biomarkers that allow prediction response and, therefore, patient selection, major unmet need. Herein, we overview linking dysfunction, pyroptosis, discuss how immunotherapy targets, at least partly, routes.
Language: Английский
Citations
3