Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(10), P. 1130 - 1167
Published: Aug. 1, 2024
The intratumoral microbiome (TM) refers to the microorganisms in tumor tissues, including bacteria, fungi, viruses, and so on, is distinct from gut circulating microbiota. TM strongly associated with tumorigenesis, progression, metastasis, response therapy. This paper highlights current status of TM. Tract sources, adjacent normal tissue, circulatory system, concomitant co-metastasis are main origin advanced techniques analysis comprehensively summarized. Besides, involved progression through several mechanisms, DNA damage, activation oncogenic signaling pathways (phosphoinositide 3-kinase [PI3K], signal transducer activator transcription [STAT], WNT/β-catenin, extracellular regulated protein kinases [ERK]), influence cytokines induce inflammatory responses, interaction microenvironment (anti-tumor immunity, pro-tumor microbial-derived metabolites). Moreover, promising directions therapy include immunotherapy, chemotherapy, radiotherapy, application probiotics/prebiotics/synbiotics, fecal transplantation, engineered microbiota, phage therapy, oncolytic virus inherent challenges clinical also review provides a comprehensive landscape for analyzing TM, especially TM-related mechanisms TM-based treatment cancer.
Language: Английский
Citations
8
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 323 - 335
Published: July 2, 2024
Language: Английский
Citations
7
MedComm, Journal Year: 2023, Volume and Issue: 4(5)
Published: Sept. 26, 2023
Abstract The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not fully uncovered. In this review, we illustrated that similar other components microenvironment, reside composition intratumor are regulated by cells surrounding microenvironment. hypoxic, immune suppressive, highly permeable microenvironment may select certain microbiomes, directly interact with via molecular binding or secretions. Conversely, microbiomes plays progression mutational landscape, function genes modulating including immunity, inflammation, angiogenesis, stem cell niche, etc. Moreover, is anti‐cancer therapies actively influences therapy response, which could be therapeutic target engineered weapon clinic. This review highlights component uncovers potential mutual between microbiome, points out ongoing research directions drawbacks area, should broaden our view enlighten further investigation directions.
Language: Английский
Citations
11
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Plant-derived cytoderm ghost (PCG) drug delivery systems leverage bacterial responsiveness to enable controlled release of drugs for treatment related diseases.
Language: Английский
Citations
0
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Oct. 28, 2024
Abstract Neoadjuvant immunochemotherapy (NAIC) achieves superior clinical benefits over neoadjuvant chemotherapy (NAC) in multiple types of human cancers, including gastric adenocarcinoma (GAC). However, it is poorly understood how the malignant epithelial cells and tumor immune microenvironment (TIME) might respond distinctly to NAIC NAC that underlies therapeutic efficacy. Here treatment‐naive paired tissues from centers were subjected pathological, immunological, transcriptomic analysis. demonstrated significantly increased rate pathological complete response compared (pCR: 25% vs. 4%, p < 0.05). Interestingly, pretreatment intestinal subtype Lauren's classification was predictive pathologic regression following NAIC, but not NAC. A substantial portion cancers underwent intestinal‐to‐diffuse transition, which occurred less correlated with treatment failure. Moreover, prevented reprogramming an immunosuppressive TIME active fibroblasts exhausted CD8 + T cells, numbers mature tertiary lymphoid structures. Mechanistically, activation necrosis factor alpha (TNFα)/nuclear factor‐kappa B (NF‐κB) signaling pathway associated NAIC. Together, for locally advanced GAC, likely due reduced conversion immuno‐active TIME. Modulation histological could be translatable approaches improve
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)
Published: July 25, 2024
Abstract Living therapy based on bacterial cells has gained increasing attention for their applications in tumor treatments. Bacterial can naturally target to sites and active the innate immunological responses. The intrinsic advantages of bacteria attribute development biohybrid living carriers targeting delivery toward hypoxic environments. rationally engineered integrate various functions enhance reduce toxic side effects. In this review, antitumor effects application are discussed as therapeutic agents across multiple platforms. kinds used cancer first introduced demonstrated mechanism well Additionally, study focused genetically modified production system treat cancer. combination with functional nanomaterials is then brief, rational design highlighted a rapid pointed out potentials clinical applications.
Language: Английский
Citations
0
Bone Reports, Journal Year: 2024, Volume and Issue: 23, P. 101809 - 101809
Published: Oct. 11, 2024
Emerging insights in osteoimmunology have enabled researchers to explore depth the role of immune modulation regulating bone health. Bone is one common sites metastasis notably case breast cancer, prostate cancer and several other types. High calcium ion concentration presence factors within mineralized matrix including TGF-β, BMP etc., aid tumor growth proliferation. Accumulating evidence has substantiated gut-microbiota (GM) tumorigenesis, further providing a strong impetus for growing "immune-cancer-gut microbiota" relationship. Recent advancements research highlight importance intra-tumor microbiota conjunction with GM metastasis. Intratumoral owing their ability cause genetic instability, mutations, epigenetic modifications microenvironment, been recognized affect cell physiology. The host system crosstalk shapes innate adaptive arms system, which key player progression. In this review, we aim decipher microorganisms mediating by shedding light on immuno-onco-microbiome (IOM) axis. We discussed feasible therapeutic interventions based microbiome-immune axis includes prebiotics, probiotics, postbiotics. Here, leverage conceptual framework published articles microbiota-based therapies target metastases. Understanding complicated nexus will provide into fundamental governing metastases subsequently help managing malignancy better efficacy.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 29, 2024
Colonization of the human gut and tumor tissue by non-pathogenic fungi has emerged as a potential risk factor associated with cancer epidemics. Therefore, we aimed to conduct systematic review assess role fungal colonization in gastrointestinal (GI) tumors increasing diagnostic efficiency.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 26, 2024
Enterosorption may contribute to the reactivation of anticancer immunity and be an effective approach tumor growth control
Language: Английский
Citations
0
OBM Genetics, Journal Year: 2024, Volume and Issue: 08(02), P. 1 - 8
Published: May 28, 2024
Bacteriophages, or phages, are viruses that infect bacteria, exhibiting specificity towards particular bacterial strains. Despite being overshadowed by traditional antibiotics in the West, interest phage therapy has resurged due to escalating antimicrobial resistance crisis. Understanding biology, selection, production, and pharmacology is crucial for their clinical application. Phages interact intricately with human microbiome, influencing populations potentially offering therapeutic avenues microbiome-related diseases. Moreover, phages present a promising alternative combat antibiotic resistance, leveraging evolutionary adaptability. Regulatory approval standardization challenges persist, yet ongoing research underscores potential of medicine.
Language: Английский
Citations
0