Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma Characterization: A Review of the Evolution, Applications, and Potentials

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 296 - 296

Published: March 20, 2024

In this paper, we discuss how the clustering analysis technique can be applied to analyze functional magnetic resonance imaging (fMRI) time-series data in context of glioblastoma (GBM), a highly heterogeneous brain tumor. The precise characterization GBM is challenging and requires advanced analytical approaches. We have synthesized existing literature provide an overview algorithms help identify unique patterns within dynamics GBM. Our review shows that fMRI time series has great potential for improving differentiation between various subtypes GBM, which pivotal developing personalized therapeutic strategies. Moreover, method proves effective capturing temporal changes occurring enhancing monitoring disease progression response treatment. By thoroughly examining consolidating current research, paper contributes understanding techniques refine This article emphasizes importance incorporating cutting-edge into neuroimaging neuro-oncology research. providing detailed perspective, approach may guide future investigations boost development tailored strategies

Language: Английский

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Single‐cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild‐type glioma

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Nov. 1, 2024

Abstract Mutations in isocitrate dehydrogenase (IDH) are important markers of glioma prognosis. However, few studies have examined the gene expression regulatory network (GRN) IDH‐mutant and wild‐type gliomas. In this study, single‐cell RNA sequencing spatial transcriptome were used to analyze GRN cell subsets patients with Through transcriptional regulation analysis, we identified M4 module, whose transcription factor activity is highly expressed IDH gliomas compared IDH‐mutants. Enrichment analysis revealed that these genes predominantly microglia macrophages, significant enrichment interferon‐related signaling pathways. Interferon 7 (IRF7), a within pathway, showed highest percentage was primarily localized core region tumors. A machine‐learning prognostic model novel subgroups population. Additionally, IRF7 shown promote proliferation migration T98G U251 cells vitro, its knockdown affected vivo. This study systematically established mechanism at level drew corresponding map. The presents map for gliomas, involving transcriptomics identify networks, machine learning models subtyping, experimental validation, highlighting role progression.

Language: Английский

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Thyroid status in patients with early stages of cancer of various localization

Research and Practical Medicine Journal, Journal Year: 2024, Volume and Issue: 11(2), P. 46 - 56

Published: May 20, 2024

Purpose of the study . To determine thyroid status primary cancer patients in early stages uterine body cancer, kidney breast skin melanoma and lung without a history endocrine pathology. Patients methods The content levels thyroid-stimulating hormone (TSH), hormones (THs) T4 T3 total free forms were determined blood serum by RIA method 132 with (average age 55 years). comparison group consisted practically healthy donors. Results Only melanoma, TSH reduced 1.5 times ( p < 0.05). was 1.4–1.7 0.05) increased 16 % though A 1.3–1.5‑fold low (p level found while an 1.6‑fold increase cancer. revealed changes THs type clinical hyperthyroidism are 1.8 FT3 on background hyperthyroxinemia consisting concentrations FT3, as well FT4, patients, may be associated features malignant pathology, since it is known that proliferation stimulants can build up tumors. Conclusion. development tumor even disease perceived threat for homeostasis response to occurrence neoplasm reaction hypothalamicpituitary-thyroid regulatory axis. As outcome, develop euthyroid disorder syndrome.

Language: Английский

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Research on the shared function of central neurons and breast cancer based on gene expression profile data mining: The role of EMID1 protein antibody expression

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134393 - 134393

Published: Oct. 1, 2024

Language: Английский

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Neuroscience of cancer: Research progress and emerging of the field

Ibrain, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Abstract Cancer cells immediately expand and penetrate adjoining tissues, as opposed to metastasis, that is the spread of cancer through circulatory or lymphatic systems more distant places via invasion process. We found a lack studies discussed tumor development with nervous system, by aspects cancer‐tissue (biological) chemical modulation growth cascades releasing neural‐related factors from nerve endings substances known neurotransmitters. In this review, we aimed carefully demonstrate describe interaction well reveal research progress emerging neuroscience cancer. An initial set 160 references underwent systematic review summarization. Through meticulous screening process, these data were refined, ultimately leading inclusion 98 adhered predetermined criteria. The outcomes show one formidable challenge in realm lies its intrinsic heterogeneity remarkable capacity for rapid adaptation. Despite advancements genomics precision medicine, there still need identify new molecular targets. Considering within cellular environment, including neural components, crucial addressing challenge. conclusion, provides good referential direct, indirect, biological, tissue–tumor interaction, suggesting establishment therapy techniques mechanisms controlling modifying neuron networks supply signals tumors.

Language: Английский

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Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential

Journal of Central Nervous System Disease, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 23, 2024

The field of cancer neuroscience has rapidly evolved, shedding light on the complex interplay between nervous system and cancer, with a particular focus relationship central (CNS) gliomas. Recent advancements have underscored critical influence CNS activity glioma progression, emphasizing roles neurons neuroglial cells in both onset evolution This review meticulously explores primary communication pathways gliomas, encompassing neuro-glioma synapses, paracrine mechanisms, extracellular vesicles, tunneling nanotubes, integrative CNS-immune-glioma axis. It also evaluates current emerging therapeutic interventions aimed at these proposes forward-looking perspectives for research this domain.

Language: Английский

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