A Comprehensive Review on Molecular Mechanisms, Treatments, and Brief Role of Natural Products in Hepatocellular Cancer DOI Creative Commons
Linlin Jiang, Qin Meng,

Lixiu Liu

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(9)

Published: Sept. 1, 2024

Most initial liver cancers are hepatocellular carcinomas (HCC), which make up the vast majority of cases. Hepatitis B or C virus infection as well alcohol consumption is among key risk factors. The significance most intriguing soluble factors indicators for early diagnosis and suggested targets therapy in light increasing challenges precision medicine. development HCC influenced by a complex combination between pro-inflammatory anti-inflammatory cytokines their signalling cascades. Recently,researchers aims to assess potential number distinct molecular cascade/cascade including function players with particular underlying etiologies. Increasing our knowledge signaling network that links retro differentiation inflammationmay help us find novel therapeutic develop combined therapies treatments work against tumors significant degree heterogeneity. With nursing processes at its center, comprehensive care new paradigm combines benefits primary group nursin g perfect synthesis many metrics like philosophy, plan, quality evaluation. In order treat patients serious diseases cancer, it can conduct interventions item accordance unique disease conditions each patient combine efficient approaches high-quality modes. Dietary natural products, fruits, vegetables, spices, may prevent cancer inhibiting tumor growth, protecting liver, enhancing chemotherapy.

Language: Английский

Glycolysis, the sweet appetite of the tumor microenvironment DOI Creative Commons

Zeinab Kooshan,

Lilibeth Cárdenas-Piedra,

Judith A. Clements

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 600, P. 217156 - 217156

Published: Aug. 8, 2024

Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as Warburg effect. This reprogramming is crucial adaptation that enables cancer to meet their elevated energy biosynthetic demands. Importantly, tumor microenvironment plays pivotal role shaping sustaining this shift cells. review explores intricate relationship between effect, highlighting how communication within niche regulates cell metabolism impacts progression therapeutic resistance. We discuss potential targeting effect promising strategy, with aim disrupting advantage enhancing our understanding complex interplay microenvironment.

Language: Английский

Citations

20
The Effect of Flavonoids and Topiramate on Glucose Carbon Metabolism in a HepG2 Steatosis Cell Culture Model: A Stable Isotope Study DOI Open Access
Li Ma, Qing‐Yi Lu,

Shu Lim

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 564 - 564

Published: Jan. 31, 2025

Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied weight loss but need investigation into their effects on metabolism. This study’s aim was to examine the of flavonoids or glucose carbon flux in a cell culture model steatosis. Methods: Steatosis induced HepG2 cells through exposure oleic acid (OA, 0.5 mml/L) conjugated bovine serum albumin (2:1). Additionally, 50% U13C-glucose supplied medium as stable isotope tracer. Cells were treated with DMSO, 10 μM naringenin, morin, silibinin, (44 μM) 72 h. A non-steatotic, untreated control included. Cell extracts analyzed by gas chromatography/mass spectrometry mass isotopomer distribution analysis glycogen synthesis, de novo fatty tricarboxylic (TCA) cycle activity, ribose synthesis. Groups compared ANOVA Tukey’s pair-wise testing. Results: Compared controls, OA-exposed exhibited increased lipid accumulation ORO staining (1.6-fold), enhanced palmitate reduced pyruvate carboxylase/pyruvate dehydrogenase (PC/PDH) ratio, Treatment silibinin ameliorated (1.3-fold) mitigated enhancement Morin-treated synthesis suppressed Conclusions: Potential mechanisms may include suppression relative decrease PDH pathway. Further studies needed potential utility MASLD based specific effects.

Language: Английский

Citations

1
Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis DOI Creative Commons

Biying Xiao,

Yanyu Jiang,

Shuying Yuan

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Fasting, without inducing malnutrition, has been shown to have various beneficial effects, including the inhibition of tumor initiation and progression. However, prolonged fasting poses challenges for many cancer patients, particularly those in intermediate terminal stages. Thus, there is an urgent need development mimetics which harness protective effects but more suitable patients. In this study, we first highlighted pivotal role silibinin AMP‐activated protein kinase (AMPK) pathway may serve, as a potential mimetic via screening hepatoprotective drugs. Further metabolic analysis showed that inhibited adenosine triphosphate (ATP) levels, glucose uptake diminished glycolysis process, further confirmed served mimetic. addition, synergized with silibinin, or used independently, suppress growth hepatocellular carcinoma (HCC) vivo. Mechanistically, upregulated death receptor 5 (DR5) through AMPK activation, thus promoting extrinsic apoptosis inhibiting HCC both vitro Inhibition using small interfering RNA (siRNA) compound C, inhibitor, significantly attenuated upregulation DR5 apoptotic response induced by silibinin. These findings suggest holds promise serve adjuvant drug treatment.

Language: Английский

Citations

7
Nanomedicines via the pulmonary route: a promising strategy to reach the target? DOI
M Guérin, Élise Lepeltier

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(8), P. 2276 - 2297

Published: April 8, 2024

Language: Английский

Citations

4
Fasting as Cancer Treatment: Myth or Breakthrough in Oncology DOI Open Access

Ghizal Fatima,

Abbas A Mehdi,

Ján Fedačko

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

The concept of fasting as a potential cancer treatment has garnered increasing interest, particularly in light emerging evidence linking dietary interventions to progression and therapy outcomes. This article explores whether fasting, either intermittent or prolonged, can be viable standalone for if its therapeutic lies adjunctive role. Current research suggests that induces metabolic shift, which may inhibit cell proliferation by depriving them essential nutrients. Additionally, been shown enhance the body's stress resistance, promote autophagy, possibly make cells more vulnerable standard treatments such chemotherapy radiotherapy. However, application sole remains controversial lacks substantial clinical validation. While animal models vitro studies indicate promising results, translation human trials is complex, with various types responding differently interventions. Moreover, concerns about malnutrition, loss muscle mass, overall health patients undergoing without supervision must addressed. paper critically examines myth reality surrounding treatment, reviewing key provide comprehensive understanding efficacy safety. hold promise supportive therapy, combination traditional treatments, there currently insufficient support use primary modality. Further needed establish parameters might beneficial, specific types, patient populations, optimal regimens. Thus, while idea breakthrough compelling, it complementary approach rather than solution oncology.

Language: Английский

Citations

0
Potential applications and effects of silymarin in domestic animals – a review DOI Open Access

Dražen Đuričić,

Mirela Sablić

Veterinarska stanica, Journal Year: 2024, Volume and Issue: 56(2), P. 257 - 264

Published: Aug. 16, 2024

Silymarin is a mixture of flavonolignan fractions from the medicinal plant milk thistle, which primarily used as hepatoprotector in humans and animals, acts an antioxidant, anti-inflammatory, antifibrotic, antiapoptotic agent. As dietary supplement, it increasingly to treat various liver diseases, some intoxications, prevent side effects chemotherapy protect kidneys dogs, birds, poultry, rabbits, cats, horses other animals. The use silymarin dairy cows showed improved biochemical profile cows, reduced occurrence ketosis increased production. In pigs, nutrient digestibility, total average daily feed intake, weight gain improved, while sport horses, supplementation accelerated return cortisol levels pre-exercise levels. Lipidosis or fatty disease common disorder among captive parrots. After long-term administration 100–150 mg/kg food every 8–12 hours, health condition significantly according testimonies parrot owners veterinarians. intensive poultry production systems, broilers hepatotonic, improve carcass characteristics, boost immune system intestinal health, growth promoter, laying hens egg quality. addition, mitigated negative mycotoxins broilers,chickens Japanese quails. Although numerous studies are known about effect thistle silymarin, their on animals not yet widespread.

Language: Английский

Citations

0
A Comprehensive Review on Molecular Mechanisms, Treatments, and Brief Role of Natural Products in Hepatocellular Cancer DOI Creative Commons
Linlin Jiang, Qin Meng,

Lixiu Liu

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(9)

Published: Sept. 1, 2024

Most initial liver cancers are hepatocellular carcinomas (HCC), which make up the vast majority of cases. Hepatitis B or C virus infection as well alcohol consumption is among key risk factors. The significance most intriguing soluble factors indicators for early diagnosis and suggested targets therapy in light increasing challenges precision medicine. development HCC influenced by a complex combination between pro-inflammatory anti-inflammatory cytokines their signalling cascades. Recently,researchers aims to assess potential number distinct molecular cascade/cascade including function players with particular underlying etiologies. Increasing our knowledge signaling network that links retro differentiation inflammationmay help us find novel therapeutic develop combined therapies treatments work against tumors significant degree heterogeneity. With nursing processes at its center, comprehensive care new paradigm combines benefits primary group nursin g perfect synthesis many metrics like philosophy, plan, quality evaluation. In order treat patients serious diseases cancer, it can conduct interventions item accordance unique disease conditions each patient combine efficient approaches high-quality modes. Dietary natural products, fruits, vegetables, spices, may prevent cancer inhibiting tumor growth, protecting liver, enhancing chemotherapy.

Language: Английский

Citations

0