MedComm,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: March 1, 2024
Abstract
The
circadian
clock
system
orchestrates
daily
behavioral
and
physiological
rhythms,
facilitating
adaptation
to
environmental
internal
oscillations.
Disruptions
in
rhythms
have
been
linked
increased
susceptibility
various
diseases
can
exacerbate
existing
conditions.
This
review
delves
into
the
intricate
regulation
of
diurnal
gene
expression
cell
function
by
clocks
across
diverse
tissues.
.
Specifically,
we
explore
rhythmicity
expressions,
behaviors,
functions
both
immune
non‐immune
cells,
elucidating
regulatory
effects
mechanisms
imposed
clocks.
A
detailed
discussion
is
centered
on
complex
regulating
key
cellular
signaling
pathways.
We
further
diseases,
with
a
focus
inflammatory
cancers,
systemic
diseases.
By
highlighting
intimate
interplay
between
especially
through
clock‐controlled
function,
this
contributes
development
novel
disease
intervention
strategies.
enhanced
understanding
holds
significant
promise
for
design
targeted
therapies
that
exploit
improved
treatment
efficacy.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 3, 2024
Sleep
is
essential
for
every
living
organism.
Humans
spend
about
one-third
of
their
lives
sleeping.
has
been
studied
extensively,
and
the
role
sleep
in
psychological,
mental,
physical
well-being
established
to
be
best.
The
rhythm
brain
between
wakefulness
called
circadian
rhythm,
which
mainly
controlled
by
melatonin
pineal
gland.
imbalance
this
can
lead
devastating
effects
on
health.
Vigorous
workouts
close
bedtime
interfere
with
falling
asleep.
Meal
timing
composition
significantly
affect
quality.
It
advised
avoid
large
meals,
caffeine,
alcohol
before
bedtime.
Heavy
meals
poor
hormone
disruption.
By
following
these
guidelines
enumerated
article,
individuals
improve
quality
overall
cycles,
especially
rapid
eye
movement
sleep,
have
a
profound
influence
mental
Adhering
recommended
practices
enhances
bodily
restoration,
fortifies
immune
system,
upholds
metabolic
equilibrium.
hygiene
aligned
rhythms
crucial
disease
prevention
well-being.
Healthcare
professionals
should
prioritize
optimization
strategies
patient
care
public
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 30, 2024
Breast
cancer
(BC)
is
one
of
the
most
common
and
fatal
malignancies
among
women
worldwide.
Circadian
rhythms
have
emerged
in
recent
studies
as
being
involved
pathogenesis
breast
cancer.
In
this
paper,
we
reviewed
molecular
mechanisms
by
which
dysregulation
circadian
genes
impacts
development
BC,
focusing
on
critical
clock
genes,
brain
muscle
ARNT-like
protein
1
(BMAL1)
locomotor
output
cycles
kaput
(CLOCK).
We
discussed
how
rhythm
disruption
(CRD)
changes
tumor
microenvironment
(TME),
immune
responses,
inflammation,
angiogenesis.
The
CRD
compromises
surveillance
features
activities
effectors,
including
CD8+
T
cells
tumor-associated
macrophages,
that
are
important
an
effective
anti-tumor
response.
Meanwhile,
review,
discuss
bidirectional
interactions:
age
rhythms,
aging
further
increases
risk
through
reduced
vasoactive
intestinal
polypeptide
(VIP),
affecting
suprachiasmatic
nucleus
(SCN)
synchronization,
ability
to
repair
damaged
DNA,
weakened
immunity.
These
complex
interplays
open
new
avenues
toward
targeted
therapies
combination
drugs
with
chronotherapy
potentiate
response
while
reducing
progression
for
better
outcomes.
This
review
tries
cover
broad
area
emerging
knowledge
tumor-immune
nexus
affected
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 577 - 577
Published: Jan. 11, 2025
Melatonin
is
involved
in
various
functions
such
as
the
timing
of
circadian
rhythms,
energy
metabolism,
and
body
mass
gain
experimental
animals.
However,
its
effects
on
adipose
tissue
lipid
metabolism
are
still
unclear.
This
study
analyzes
melatonin
relative
gene
expression
lipolytic
proteins
rat
mesenteric
free
fatty
acid
(FFA)
glycerol
plasma
levels
male
Wistar
rats
fed
a
high-fat
(HFD)
or
maintenance
diet.
Four
groups
were
established:
control,
obese,
control
obese
plus
2.3
mg/kg/day
tap
water.
After
11
weeks,
animals
sacrificed
at
different
times
throughout
24
h
cycle,
samples
collected
analyzed.
Cgi58,
Perilipin,
Dgat1
expression,
well
FFA
concentrations,
showed
rhythm
patterns
group.
HFD
disrupted
those
increased
concentrations
during
dark
photoperiod.
In
both
melatonin-treated
groups,
almost
all
analyzed
genes
patterns.
Notably,
significantly
prevented
increase
photoperiod
(obese
group:
~1100
mM
vs.
+
~600
μM,
similar
to
levels).
rhythmic
pattern
observed
was
not
sustained.
According
our
results,
could
regulate
transcription
lipolysis
proteins.
The
effect
preventing
elevated
associated
with
diet
intake
warrants
further
investigation.
Cell Communication and Signaling,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 16, 2025
The
complex
interaction
between
circadian
rhythms
and
physiological
functions
is
essential
for
maintaining
human
health.
At
the
heart
of
this
lies
PERIOD
proteins
(PERs),
pivotal
to
clock,
influencing
timing
behavioral
processes
impacting
oxidative
stress,
immune
functionality,
tumorigenesis.
PER1
orchestrates
cooperation
enzyme
GPX1,
modulating
mitochondrial
dynamics
in
sync
with
daily
thus
regulating
mechanisms
managing
energy
substrates.
PERs
innate
cells
modulate
temporal
patterns
NF-κB
TNF-α
activities,
as
well
response
LPS-induced
toxic
shock,
initiating
inflammatory
responses
that
escalate
into
chronic
conditions.
Crucially,
cancer
cell
behaviors
including
proliferation,
apoptosis,
migration
by
levels
cycle
stimulating
expression
oncogenes
c-Myc
MDM2.
PER2/3,
antagonists
stem
biology,
play
important
roles
differentiating
their
stemness.
Importantly,
Pers
serve
a
significant
factor
early
diagnosis
prognosis.
This
review
delves
link
rhythm
regulator
PERs,
disruptions
rhythm,
oncogenesis.
We
examine
evidence
highlights
how
dysfunctions
activities
initiate
development,
aid
tumor
growth,
modify
metabolism
through
pathways
involved
stress
system.
Comprehending
these
connections
opens
new
development
rhythm-based
therapeutic
strategies,
aims
boosting
enhancing
treatments.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: April 7, 2025
Increasing
evidence
suggests
that
vaccine
responses
may
vary
based
on
the
time
of
day
administration.
This
systematic
review
provides
a
comprehensive
overview
impact
vaccination
timing
immune
responses,
to
assess
its
potential
role
in
optimizing
programs.
A
literature
search
was
performed
Embase,
Medline
and
Scopus
identify
eligible
observational
studies
clinical
trials
assessed
following
at
different
times
humans.
meta-analysis
conducted
quantify
effect
size
antibody
responses.
The
identified
17
compared
day,
covering
vaccinations
against
COVID-19
(9),
influenza
(5),
hepatitis
B
(2),
(1),
pneumococcal
infection
(1).
Eleven
out
these
demonstrated
statistically
significant
effects
response,
with
10
reporting
stronger
morning
afternoon
vaccination.
Of
six
subgroups
an
average
age
60
years
older,
five
showed
significantly
vaccination,
while
sixth
only
men.
In
contrast,
16
younger
than
titers.
Similarly,
indicated
receiving
elicited
response
(SMD
=
0.24,
95%
CI
0.01-0.47),
subgroup
analyses
revealing
larger
adults
aged
65
older
0.32,
0.21-0.43)
those
or
0.00,
-0.17-0.17).
Morning
enhanced
key
demographic
for
Chrono-optimizing
administration
offer
low-risk,
low-cost
strategy
boost
effectiveness
this
group.
https://inplasy.com/inplasy-2025-1-0060/.
British Journal of Pharmacology,
Journal Year:
2024,
Volume and Issue:
181(19), P. 3743 - 3759
Published: June 11, 2024
Drug
disposition
undergoes
significant
alteration
in
patients
with
inflammatory
bowel
disease
(IBD),
yet
circadian
time-dependency
of
these
changes
remains
largely
unexplored.
In
this
study,
we
aimed
to
determine
the
temporal
effects
experimental
colitis
on
drug
and
toxicity.
Biomedical & Pharmacology Journal,
Journal Year:
2024,
Volume and Issue:
17(3), P. 2011 - 2017
Published: Sept. 30, 2024
Chronopharmacokinetics
is
a
specialized
field
within
pharmacokinetics
that
focuses
on
how
the
timing
of
drug
administration
affects
absorption,
distribution,
metabolism,
and
elimination
drugs.
The
circadian
rhythm,
governed
by
body's
biological
clock,
plays
crucial
role
in
pharmacokinetics,
which
encompasses
These
pharmacokinetic
processes
are
subject
to
daily
variations
influenced
rhythm.
Drug
absorption
can
fluctuate
due
changes
gastrointestinal
function,
such
as
motility
gastric
pH,
blood
circulation.
Similarly,
distribution
drugs
body
factors
tissue
perfusion,
plasma
protein
binding,
cell
membrane
permeability,
all
modulated
Metabolism,
especially
hepatic
also
experience
affect
rate
at
processed
converted
into
active
or
inactive
metabolites.
Finally,
drugs,
primarily
through
renal
show
rhythms
impact
excretion
compounds
from
body.
Understanding
these
fluctuations
essential
optimize
efficacy
safety
pharmacological
treatments,
dosages
times
could
be
adjusted
align
with
peaks
clock
activity.
Thus,
treatments
more
effective
have
fewer
side
effects
leveraging
variability
processes.
