Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 7, 2024
The
relationship
between
the
platelet
to
albumin
ratio
(PAR)
and
disease
activity
of
early
rheumatoid
arthritis
(ERA)
remains
be
elucidated.
This
cross-sectional
study
included
372
patients
with
ERA
who
were
hospitalized
at
Xingtai
People's
Hospital
January
2022
2024.
Multiple
linear
regression
analysis
was
employed
assess
correlation
PAR
Disease
Activity
Score
28
(DAS28)
using
erythrocyte
sedimentation
rate
(ESR)
C-reactive
protein
(CRP),
then
generalized
additive
models
used
explore
their
relationship.
After
accounting
for
confounding
variables,
a
positive
observed
DAS28-ESR
DAS28-CRP
in
(β
(95%
CI):
0.20
(0.08,
0.32)
0.33),
respectively),
general
trends
consistent
from
lowest
tertile
group
(T1)
highest
(T3).
Furthermore,
nonlinear
identified
both
DAS28-CRP.
Threshold
effect
indicated
that
value
13.73
significant
inflection
point.
In
brief,
has
threshold
on
ERA.
Increased
levels
independently
associated
among
<
13.73.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1559 - 1559
Published: Dec. 5, 2024
Autoimmune
diseases
(AIDs)
are
a
group
of
disorders
in
which
the
immune
system
attacks
body’s
own
tissues,
leading
to
chronic
inflammation
and
organ
damage.
These
difficult
treat
due
variability
drug
PK
among
individuals,
patient
responses
treatment,
side
effects
long-term
immunosuppressive
therapies.
In
recent
years,
pharmacometrics
has
emerged
as
critical
tool
discovery
development
(DDD)
precision
medicine.
The
aim
this
review
is
explore
diverse
roles
that
played
addressing
challenges
associated
with
DDD
personalized
therapies
treatment
AIDs.
Methods:
This
synthesizes
research
from
past
two
decades
on
pharmacometric
methodologies,
including
Physiologically
Based
Pharmacokinetic
(PBPK)
modeling,
Pharmacokinetic/Pharmacodynamic
(PK/PD)
disease
progression
(DisP)
population
model-based
meta-analysis
(MBMA),
Quantitative
Systems
Pharmacology
(QSP).
incorporation
artificial
intelligence
(AI)
machine
learning
(ML)
into
also
discussed.
Results:
Pharmacometrics
demonstrated
significant
potential
optimizing
dosing
regimens,
improving
safety,
predicting
patient-specific
PBPK
PK/PD
models
have
been
instrumental
personalizing
treatments,
while
DisP
QSP
provide
insights
evolution
pathophysiological
mechanisms
AI/ML
implementation
further
enhanced
these
models.
Conclusions:
plays
crucial
role
bridging
pre-clinical
findings
clinical
applications,
driving
more
effective
treatments
for
Its
integration
translational
science,
combination
AI
ML
algorithms,
holds
promise
advancing
therapeutic
strategies
autoimmune
patients’
outcomes.
Women in Sport and Physical Activity Journal,
Journal Year:
2024,
Volume and Issue:
32(1)
Published: Jan. 1, 2024
This
trial
sought
to
compare
the
effects
of
aerobic
and
resistance
exercises
on
sleep
quality,
fatigue,
depression,
exercise
capacity,
quality
life
among
women
with
rheumatoid
arthritis.
Seventy-eight
arthritis
were
randomly
allocated
into
three
equalized
groups:
training
(AT),
(RT),
nonexercising
control
group.
For
12
weeks,
conducted
times
a
week
at
moderate
intensities.
Outcome
measures
included
Pittsburgh
Sleep
Quality
Index
for
Bristol
Rheumatoid
Arthritis
Fatigue
Multi-Dimensional
Questionnaire
Beck
Depression
Inventory
II
time
exhaustion
12-Item
Short
Form
Health
Survey
components
physical
component
score
mental
life.
Comparatively
baseline
group
no
exercises,
AT
RT
groups
exhibited
substantial
improvements
in
all
outcomes
by
completion
(
p
<
.05).
In
addition,
notable
variations
found
between
regarding
Index,
Questionnaire,
II,
score,
>
The
group,
however,
revealed
greater
significant
increases
than
(53.19%
vs.
15.44%,
=
.001).
All
outcome
indicators
showed
statistically
changes
arthritis,
could
be
similarly
beneficial
as
improving
Nevertheless,
have
gains
capacity
such
women.
Genes & Nutrition,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 10, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
autoimmune
disorder.
The
present
study
aimed
to
evaluate
the
in
silico,
vitro,
and
vivo
inhibitory
effect
of
visnagin
on
malate
dehydrogenase
activity
elucidate
its
efficacy
when
combined
with
methotrexate
RA
rat
model.
molecular
docking,
ADMET
simulations,
MDH
activity,
expression,
X-ray
imaging
were
detected.
Moreover,
CRP,
RF,
(anti-CCP)
antibody,
(TNF-α),
(IL-6),
(IL-17),
(IL-10)
evaluated.
expression
levels
MMP3
FOXP3
genes
CD4,
CD25,
CD127
protein
assessed.
Histological
assessment
ankle
joints
was
results
revealed
that
showed
reversible
competitive
inhibition
constant
(Ki)
equal
141
mM
theoretical
IC50
1202.7
mM,
LD50
155.39
mg/kg,
LD25
77.69
mg/kg.
In
studies
indicated
exhibited
anti-inflammatory
effects
through
decreasing
MDH1
induced
proliferation
CD4
Patient-Oriented Medicine and Pharmacy,
Journal Year:
2024,
Volume and Issue:
2(3), P. 13 - 20
Published: Oct. 31, 2024
Relevance.
Activation
of
innate
and
acquired
immunity,
accompanied
by
increased
production
classical
(interleukin
(IL)
IL-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α)
interferon-γ
(INF-γ))
proinflammatory
cytokines
in
synovial
fluid
blood
serum,
plays
an
important
role
the
pathogenesis
rheumatoid
arthritis
(RA).
Objective.
To
determine
concentration
TNF-α
INF-γ
RA
patients
advanced
stage
disease,
to
evaluate
relationship
between
them,
clinical
indices
disease
activity,
presence
factor
(RF),
antibodies
cyclic
citrullinated
peptide
(ACCP).
Material
methods.
We
examined
154
with
(41
men
113)
who
were
middle-aged
(56.0
(50.0;
64.0)
years),
duration
(9.4
(3.0;
13.0)
seropositive
129
(83.8
%)
for
IgM
RF
and/or
106
(68.8
ACCP
moderate
high
(DAS28-ESR
—
5.40
(4.65;
6.00))
activity.
The
serum
determined
multiplex
technology.
Results.
IL-1β
was
not
significantly
different
controls.
values
IL-6
higher,
lower
than
donors.
hyperproduction
detected
most
frequently
(51.6
%),
whereas
elevated
levels
(38.96
(26.62
(23.38
less
common.
Significant
positive
correlations
observed
concentrations
all
their
levels.
strongest
characteristic
INF-γ.
No
statistically
significant
differences
cytokine
or
negative
IgM-RF
ACCP.
alone
positively
correlated
(DAS28-ESR,
CDAI,
SDAI)
activity
(p<0.05).
Conclusions.
There
are
frequencies
among
advanced-stage
RA.
In
a
close
there
certain
associations
laboratory
indicators
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 7, 2024
The
relationship
between
the
platelet
to
albumin
ratio
(PAR)
and
disease
activity
of
early
rheumatoid
arthritis
(ERA)
remains
be
elucidated.
This
cross-sectional
study
included
372
patients
with
ERA
who
were
hospitalized
at
Xingtai
People's
Hospital
January
2022
2024.
Multiple
linear
regression
analysis
was
employed
assess
correlation
PAR
Disease
Activity
Score
28
(DAS28)
using
erythrocyte
sedimentation
rate
(ESR)
C-reactive
protein
(CRP),
then
generalized
additive
models
used
explore
their
relationship.
After
accounting
for
confounding
variables,
a
positive
observed
DAS28-ESR
DAS28-CRP
in
(β
(95%
CI):
0.20
(0.08,
0.32)
0.33),
respectively),
general
trends
consistent
from
lowest
tertile
group
(T1)
highest
(T3).
Furthermore,
nonlinear
identified
both
DAS28-CRP.
Threshold
effect
indicated
that
value
13.73
significant
inflection
point.
In
brief,
has
threshold
on
ERA.
Increased
levels
independently
associated
among
<
13.73.
