Nanoparticles, a promising treatment for gastric cancer

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Clinical advances and challenges associated with TCR-T cell therapy for cancer treatment

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Background T cell receptor (TCR)-T therapy is an innovative form of cancer immunotherapy that genetically modifies patients’ cells to target and destroy cells. However, the current status clinical trials TCR-T for treatment remains unclear. This study aimed comprehensively analyze registration related cancer. Methods A comprehensive search was conducted in Trialtrove database all registered by August 1, 2024. Inclusion criteria focused on targeting oncology, excluded observational studies incomplete data. Statistical analysis performed key trial characteristics, with between-group comparisons utilizing chi-square or Fisher’s exact tests. Results Analysis 174 eligible revealed exhibits significant efficacy across various tumor types, particularly refractory hematologic malignancies certain solid tumors. Additionally, combining other immunotherapies enhanced these anti-tumor effects. Conclusion holds substantial promise treatment. Future research should focus optimizing protocols, enhancing efficacy, minimizing prices fully realize potential this therapy.

Language: Английский

A review of innovative design strategies: Artificial antigen presenting cells in cancer immunotherapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125053 - 125053

Published: Dec. 1, 2024

Language: Английский