Impact of liquid–liquid phase separation- and immune-related gene signatures on multiple myeloma prognosis: focus on DDX21 and EZH2 DOI Creative Commons
Fengming Wang, Changxian Shen

Hematology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 23, 2024

Objective: Liquid–liquid phase separation (LLPS) may affect the therapeutic sensitivity of multiple myeloma (MM). This study aimed to identify LLPS-related genes with MM prognostic values and confirm their effects on tumor progression.

Language: Английский

Intrinsic Disorder in Protein Interaction Networks Linking Cancer with Metabolic Diseases DOI

Veda Naga Priya Vangala,

Vladimir N. Uversky

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108493 - 108493

Published: April 1, 2025

Language: Английский

Citations

0
Liquid-liquid phase separation: a new perspective on respiratory diseases DOI Creative Commons
Li Wang, Yongjun Wang, Z. J. Ke

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 26, 2024

Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS human health disease. However, its implications respiratory diseases remain poorly understood. This review explores current insights into mechanisms LLPS, focusing particularly on relevance diseases, aiming deepen our understanding propose new paradigm for studying this context.

Language: Английский

Citations

2
Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure DOI Creative Commons

H Abdelrasol,

A Chopra, Liana Shvachiy

et al.

Cell Stress, Journal Year: 2024, Volume and Issue: 8, P. 83 - 98

Published: Oct. 18, 2024

Abstract Stress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell survival. Here, we investigate whether established cytotoxic agents, such as the platinum-based chemotherapeutic agent cisplatin and aminoglycoside antibiotic gentamicin, elicit SG formation House Ear Institute-Organ Corti-1 (HEI-OC1) auditory line, H4 human neuroglioma HEK-293T embryonic kidney cells. Cells were treated with or gentamicin specific durations at designated concentrations. was assessed using immunocytochemistry live imaging. Levels proteins involved assembly evaluated immunoblotting. We observed cisplatin-associated HEI-OC1 via confocal microscopy through antibody colabeling G3BP1 PABP Caprin1. While maintaining an unchanged pattern expression main constituent proteins, cisplatin-related persisted least 12 h after drug removal. exposure did not exhibit SGs. Our findings offer insights into subcellular mechanisms related cytotoxicity, highlighting need future studies further this stress-response mechanism.

Language: Английский

Citations

0
Impact of liquid–liquid phase separation- and immune-related gene signatures on multiple myeloma prognosis: focus on DDX21 and EZH2 DOI Creative Commons
Fengming Wang, Changxian Shen

Hematology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 23, 2024

Objective: Liquid–liquid phase separation (LLPS) may affect the therapeutic sensitivity of multiple myeloma (MM). This study aimed to identify LLPS-related genes with MM prognostic values and confirm their effects on tumor progression.

Language: Английский

Citations

0