Emerging biomaterials and bio-nano interfaces in pulmonary hypertension therapy: transformative strategies for personalized treatment DOI Creative Commons
Xiaofa Chen, Lina Xu, Haiyan Shi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling right heart failure despite the therapeutic advances made in recent past. Biomaterials offer attractive route to break current paradigms by inducing repair, facilitating drug targeting, allowing dynamic regeneration of tissue. This review taking integrated approach investigates revolutionary role played novel biomaterials bio–nano interfaces PH treatment. We classify evaluate several classes biomaterial platforms including natural polymers, scaffolds based on synthetic extracellular vesicles (EVs), stimulus-responsive systems emphasis both underlying mechanisms clinical relevance. further address progress artificial intelligence (AI)-based integrating multi-omics tools provide patient-tailored therapy. finally touch ongoing limitations enumerate future directions required take forward biomaterial-based therapies towards reality.

Language: Английский

The Integration of Cholesterol‐Polyethylene Glycol‐Folic Acid Conjugate and Iron Oxide Nanoparticles for A Multi Targeted and Stimuli Responsive Drug Delivery System of Quercetin DOI Open Access
Ngoc Hoi Nguyen,

Tien‐Dung Nguyen‐Dinh,

Tan Phat Nguyen

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

ABSTRACT This research focused on developing a multi‐targeted, stimuli‐responsive drug delivery system by integration of iron oxide nanoparticles (IONPs) and Cholesterol‐Polyethylene glycol‐Folic acid conjugate (CPF) to enhance the poorly water‐soluble drugs. Oleic (OA) coated (OCION) were synthesized subsequently functionalized with CPF form OCION–CPF. Quercetin (QCT), model soluble drug, was encapsulated into using thin film method. Analytical techniques, including dynamic light scattering (DLS), zeta potential measurement, Fourier‐transform infrared spectroscopy (FT‐IR), proton nuclear magnetic resonance ( 1 H‐NMR) energy‐dispersive X‐ray (EDX), confirmed successful synthesis functionalization nanoparticles. The OCION–CPF demonstrated high encapsulation efficiency for QCT pH‐responsive release, as shown loading capacity release kinetics study. exhibited dual‐targeting due properties OCION folate receptor binding ability conferred folic (FA) modification. OA, Chol, PEG, FA IONPs addressed limitations individual targeting strategies, enhancing stability effectiveness delivering approach presents promising advancement in targeted efficient technologies.

Language: Английский

Citations

0
Comprehensive Review on the Development of Phytonanomedicines for Cancer Treatment DOI

Donald A. Fernandes

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

0
Nanomaterials in Regenerative Medicine: Advancing the Future of Tissue Engineering DOI
Ravikumar Jayabal

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Emerging biomaterials and bio-nano interfaces in pulmonary hypertension therapy: transformative strategies for personalized treatment DOI Creative Commons
Xiaofa Chen, Lina Xu, Haiyan Shi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling right heart failure despite the therapeutic advances made in recent past. Biomaterials offer attractive route to break current paradigms by inducing repair, facilitating drug targeting, allowing dynamic regeneration of tissue. This review taking integrated approach investigates revolutionary role played novel biomaterials bio–nano interfaces PH treatment. We classify evaluate several classes biomaterial platforms including natural polymers, scaffolds based on synthetic extracellular vesicles (EVs), stimulus-responsive systems emphasis both underlying mechanisms clinical relevance. further address progress artificial intelligence (AI)-based integrating multi-omics tools provide patient-tailored therapy. finally touch ongoing limitations enumerate future directions required take forward biomaterial-based therapies towards reality.

Language: Английский

Citations

0