Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Recent evidence suggests a more important role of the gut microbiota in neurodegenerative diseases (NDDs) given its relationship through microbiota‐gut‐brain as an active communication system aiding maintaining homeostasis between brain and gut. This review focuses on how modulation can serves therapeutic strategy for NDDs, emphasizing neuroprotective effects probiotics. Probiotics are live microorganisms that confer health benefits, their interaction with gut‐microbiota influences neurogenesis, neurotransmitter regulation, neuroinflammation. advancements, including germ‐free animal models, fecal transplantation (FMT), diverse probiotic strains, have revealed underlying mechanisms linking to function. Notably, several Lactobacillus Bifidobacterium species been shown exert via upregulation neurotrophic factors such brain‐derived factor enhancing mitochondrial function reducing impacts oxidative stress. Interestingly, FMT has exhibited degree success overcoming cognitive impairment motor deficits preclinical studies clinical trials. However, further research is warranted explore potential humans. Overall, this highlights significant NDDs advocates gut‐targeted interventions innovative approaches mitigate these diseases.

Language: Английский

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The Hidden Influence of Methanogens in the Gut Microbiota

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Methanogens are a distinct group of archaea characterized by their ability to produce methane as metabolic byproduct. These microorganisms play crucial role in the gut microbiota, influencing various physiological processes, including digestion, immune modulation, and gut-brain axis. Although abundance is lower compared bacteria, impact methanogens on health disease significant. This review aims elucidate hidden influence within with particular focus associations gastrointestinal neurological disorders. By synthesizing recent findings, seeks underscore critical offer novel insights into potential therapeutic strategies aimed at targeting these archaea.

Language: Английский

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Current Trends in Pediatric Migraine: Clinical Insights and Therapeutic Strategies

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 280 - 280

Published: March 6, 2025

Background/Objectives: Pediatric migraine is a prevalent neurological disorder that significantly impacts children’s quality of life, academic performance, and social interactions. Unlike migraines in adults, pediatric often present differently involve unique underlying mechanisms, making diagnosis treatment more complex. Methods: This review discusses the clinical phases migraine, key trigger factors, sex- age-related differences, role childhood maltreatment development. We also discuss episodic syndromes such as cyclic vomiting syndrome, abdominal benign paroxysmal vertigo, torticollis, along with comorbidities psychiatric disorders, sleep disturbances, epilepsy. Results: The pathophysiological mechanisms for migraines, including genetic predispositions, neuroinflammation, gut microbiota dysbiosis, are summarized. Current therapeutic strategies, conventional emerging pharmacological treatments, nutraceuticals, non-pharmacological approaches, evaluated. Non-pharmacological particularly evidence-based lifestyle interventions stress management, diet, hydration, sleep, exercise, screen time moderation, cognitive behavioral therapy, highlighted components prevention management. long-term prognosis follow-up patients reviewed, emphasizing importance early diagnosis, tailored multidisciplinary care to prevent chronic progression. Conclusions: Future research should focus on novel targets integrating gut–brain axis modulation, need longitudinal studies better understand course migraine.

Language: Английский

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Enteric nervous system dysfunction as a driver of central nervous system disorders: The Forgotten brain in neurological disease

Neuroscience, Journal Year: 2025, Volume and Issue: 572, P. 232 - 247

Published: March 13, 2025

Language: Английский

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Association of the dietary index for gut microbiota with sleep disorder among US adults: the mediation effect of dietary inflammation index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 17, 2025

Previous studies have confirmed the relationship between gut microbiota and sleep disorders, characterized by persistent inability to achieve adequate sleep, with dietary composition playing a key role in maintaining homeostasis. Our study aims explore newly proposed Dietary Index for Gut Microbiota (DI-GM) as well whether Inflammatory (DII) mediates this relationship. This is based on data from 30,406 participants National Health Nutrition Examination Survey (NHANES) 2005 2018, cross-sectional survey that represents U.S. adult population. We used multivariable logistic regression models examine DI-GM disorders. Subgroup interaction analyses were conducted assess stability of results. Mediation analysis was employed effect The score significantly negatively correlated After adjusting covariates, each unit increase associated 5% reduction prevalence disorders (p < 0.001). Additionally, there trend toward decrease increasing (trend p 0.05). Dose-response curve revealed linear higher scores being lower DII positively 0.001) decreased increased (β = -0.37, showed mediated mediation proportion 27.36% results indicate A incidence while Specifically, an may attenuate protective

Language: Английский

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Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut–microbiota–brain axis hypothesis study

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 2, 2025

Based on the microbiota-gut-brain axis (MGBA) hypothesis, probiotics play an increasingly important role in treating various psychiatric disorders. Schizophrenia (SCZ) is a common mental disease with complex pathogenesis and challenging to treat. Although studies have elucidated mechanisms associated interactions between SCZ, few specifically used as therapeutic intervention for SCZ. Accordingly, current study determines whether L. johnsonii YH1136 effectively prevents SCZ-like behavior mice identifies key microbes metabolites. An SCZ mouse model was established by intraperitoneal injection of MK-801; administered via oral gavage. significantly improves abnormal behaviors, including psychomotor hyperactivity sociability alleviates aberrant enzyme expression tryptophan metabolism mice. Additionally, upregulates hippocampal brain-derived neurotrophic factor (BDNF) levels while downregulating 2,3-dioxygenase (TDO2), indoleamine-pyrrole 1 (IDO1), kynurenine aminotransferase (KAT1). Subsequent 16S rRNA sequencing intestinal contents suggests that modulates gut flora structure composition increasing relative abundance Lactobacillus decreasing Dubosiella N-acetylneuraminic acid hypoxanthine are serum metabolites mediating interaction MGBA These results partially reveal mechanism underlying effects mice, supporting development probiotic formulations against

Language: Английский

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Role of Microbiota-Derived Hydrogen Sulfide (H2S) in Modulating the Gut–Brain Axis: Implications for Alzheimer’s and Parkinson’s Disease Pathogenesis

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2670 - 2670

Published: Nov. 23, 2024

Microbiota-derived hydrogen sulfide (H2S) plays a crucial role in modulating the gut–brain axis, with significant implications for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. H2S is produced by sulfate-reducing bacteria gut acts critical signaling molecule influencing brain health via various pathways, including regulating inflammation, oxidative stress, immune responses. maintains barrier integrity at physiological levels prevents systemic which could impact neuroinflammation. However, has dual or Janus face, excessive production, often resulting from dysbiosis, can compromise intestinal exacerbate processes promoting neuroinflammation glial cell dysfunction. This imbalance linked to early pathogenesis of Parkinson’s diseases, where overproduction exacerbates beta-amyloid deposition, tau hyperphosphorylation, alpha-synuclein aggregation, driving neuroinflammatory responses neuronal damage. Targeting microbiota restore homeostasis through dietary interventions, probiotics, prebiotics, fecal transplantation presents promising therapeutic approach. By rebalancing microbiota-derived H2S, these strategies may mitigate neurodegeneration offer novel treatments underscoring axis maintaining central nervous system health.

Language: Английский

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Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12613 - 12613

Published: Nov. 24, 2024

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS, and Huntington's, remain formidable challenges in medicine, with their relentless progression limited therapeutic options. These diseases arise from a web of molecular disturbances-misfolded proteins, chronic neuroinflammation, mitochondrial dysfunction, genetic mutations-that slowly dismantle neuronal integrity. Yet, recent scientific breakthroughs are opening new paths to intervene these once-intractable conditions. This review synthesizes the latest insights into underlying dynamics neurodegeneration, revealing how intertwined pathways drive course diseases. With an eye on most promising advances, we explore innovative therapies emerging cutting-edge research: nanotechnology-based drug delivery systems capable navigating blood-brain barrier, gene-editing tools like CRISPR designed correct harmful variants, stem cell strategies that not only replace lost neurons but foster neuroprotective environments. Pharmacogenomics is reshaping treatment personalization, enabling tailored align individual profiles, while diagnostics biomarkers ushering era early, precise disease detection. Furthermore, novel perspectives gut-brain axis sparking interest mounting evidence suggests microbiome modulation may play role reducing neuroinflammatory responses linked neurodegenerative progression. Taken together, advances signal shift toward comprehensive, personalized approach could transform care. By integrating techniques, this offers forward-looking perspective future where treatments aim just manage symptoms fundamentally alter progression, presenting renewed hope for improved patient outcomes.

Language: Английский

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The Association of the Oral Microbiota with Cognitive Functioning in Adolescence

Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1263 - 1263

Published: Sept. 27, 2024

: A growing body of research supports the role microbial communities residing in digestive system host's cognitive functioning. Most these studies have been focused on gut microbiome and its association with clinical phenotypes middle-aged older adults. There is an insufficiency population-based exploring normative functioning particularly oral microbiota.

Language: Английский

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