Comparison of Morbidity and Mortality in Patients with Jejunoileal Perforation presented before and after 24 hours in Surgery Department DOI

Muhammad Hanif Bugti,

Shoaib Ahmed Qureshi,

Rehan Zarkoon

et al.

Indus journal of bioscience research., Journal Year: 2024, Volume and Issue: 2(2), P. 842 - 849

Published: Dec. 12, 2024

Background: Jejunoileal perforations are critical conditions that can lead to significant morbidity and mortality. Timely intervention is essential prevent complications improve patient outcomes. Objective: This study aims compare the mortality rates of patients with jejunoileal who presented within 24 hours symptom onset versus those after in surgery department Bolan Medical Complex, Quetta. It seeks evaluate impact delayed presentation on surgical Methods: A qualitative approach was employed, involving semi-structured interviews record reviews for 120 diagnosed perforation. The participants were divided into two groups: Group (presented hours) B hours). Data analyzed thematically identify differences morbidity, mortality, recovery experiences. Results: findings reveal exhibited significantly lower compared B. Complications noted 30% cases B, whereas only 10% experienced complications. average hospital stay longer averaging 7 days 3 A. Conclusion: Early crucial reducing underscores importance timely medical attention improving outcomes enhancing recovery.

Language: Английский

Efficacy of Microbiome-Targeted Interventions in Obesity Management- A comprehensive systematic review DOI
Dhivya Dhanasekaran, M. Venkatesan, Sarvesh Sabarathinam

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103208 - 103208

Published: Feb. 1, 2025

Language: Английский

Citations

3
Microbiota and metabolomic profiling coupled with machine learning to identify biomarkers and drug targets in nasopharyngeal carcinoma DOI Creative Commons
Junsong Liu, Chongwen Xu,

Rui Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in certain regions, with radiotherapy as the standard treatment. However, resistance to remains critical challenge, necessitating identification of novel biomarkers and therapeutic targets. The tumor-associated microbiota metabolites have emerged potential modulators outcomes. This study included 22 NPC patients stratified into radiotherapy-responsive (R, n = 12) radiotherapy-non-responsive (NR, 10) groups. Tumor tissue fecal samples were subjected 16S rRNA sequencing profile composition targeted metabolomics quantify short-chain fatty acids (SCFAs). XGBoost algorithm was applied identify microbial taxa associated response, quantitative PCR (qPCR) used validate key findings. Statistical analyses conducted assess differences diversity, relative abundance, metabolite levels between Significant alpha diversity at species level observed R NR Bacteroides acidifaciens enriched group, while Propionibacterium acnes Clostridium magna more abundant group. Machine learning identified Acidosoma, acnes, predictors response. Metabolomic profiling revealed elevated acetate implicating its role tumor growth immune evasion. Validation via qPCR confirmed differential abundance these both samples. Our findings highlight interplay profiles influencing outcomes NPC. These results suggest that targeting microbiota-metabolite axis may enhance efficacy

Language: Английский

Citations

0
Targeting KRAS-G12C in Lung Cancer: The Emerging Role of PROTACs in Overcoming Resistance DOI

Kumarappan Chidambaram,

Arcot Rekha, Ahsas Goyal

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155954 - 155954

Published: April 1, 2025

Language: Английский

Citations

0
Tumor-educated platelets in lung cancer DOI
Md Sadique Hussain, Ehssan Moglad, Ahsas Goyal

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120307 - 120307

Published: April 1, 2025

Language: Английский

Citations

0
Holobiome Harmony: Linking Environmental Sustainability, Agriculture, and Human Health for a Thriving Planet and One Health DOI Creative Commons
Gissel Garcı́a, Martha Carlin, Raúl J. Cano

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 514 - 514

Published: Feb. 26, 2025

The holobiome is an interconnected network of microbial ecosystems spanning soil, plants, animals, humans, and the environment. Microbial interactions drive nutrient cycling, pathogen suppression, climate regulation. Soil microbiomes facilitate carbon sequestration enhance soil fertility, while marine contribute to capture stability. However, industrial agriculture, extensive herbicide use, antibiotic overuse, change threaten diversity, leading ecosystem health disruptions. Probiotic interventions help restore balance. In human health, probiotics support gut microbiota reduce inflammation, regulate metabolism. improve degrade contaminants, increasing crop yields health. Case studies show that inoculants effectively remediate degraded soils uptake. Artificial intelligence transforming microbiome research by enabling predictive modeling, precision probiotic design, consortia optimization. Interdisciplinary collaboration supportive policies are essential for restoring equilibria, ensuring resilience, promoting long-term sustainability. integration artificial intelligence, clinical research, sustainable practices crucial advancing science. framework underscores need interdisciplinary address global challenges, bridging environmental sustainability, public a resilient future.

Language: Английский

Citations

0
Hierarchical network modulation of cell death regulators and inflammatory genes by biogenically engineered gold nanoconstructs with CK in gastric tumorigenesis DOI Creative Commons
Abdus Samad, A. Gnanasekaran,

Yeon Ju Kim

et al.

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Language: Английский

Citations

0
Comparison of Morbidity and Mortality in Patients with Jejunoileal Perforation presented before and after 24 hours in Surgery Department DOI

Muhammad Hanif Bugti,

Shoaib Ahmed Qureshi,

Rehan Zarkoon

et al.

Indus journal of bioscience research., Journal Year: 2024, Volume and Issue: 2(2), P. 842 - 849

Published: Dec. 12, 2024

Background: Jejunoileal perforations are critical conditions that can lead to significant morbidity and mortality. Timely intervention is essential prevent complications improve patient outcomes. Objective: This study aims compare the mortality rates of patients with jejunoileal who presented within 24 hours symptom onset versus those after in surgery department Bolan Medical Complex, Quetta. It seeks evaluate impact delayed presentation on surgical Methods: A qualitative approach was employed, involving semi-structured interviews record reviews for 120 diagnosed perforation. The participants were divided into two groups: Group (presented hours) B hours). Data analyzed thematically identify differences morbidity, mortality, recovery experiences. Results: findings reveal exhibited significantly lower compared B. Complications noted 30% cases B, whereas only 10% experienced complications. average hospital stay longer averaging 7 days 3 A. Conclusion: Early crucial reducing underscores importance timely medical attention improving outcomes enhancing recovery.

Language: Английский

Citations

0