Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

USP48 inhibits colorectal cancer progression and promotes M1-like macrophage polarization by stabilizing TAK1 DOI
Xinwen Zhang, Jiawei Zhao,

Guangying Qi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 446(1), P. 114469 - 114469

Published: Feb. 18, 2025

Language: Английский

Citations

0
Ubiquitin-specific protease: an emerging key player in cardiomyopathy DOI Creative Commons
Danlei Li, Qilin Ma

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and key component of ubiquitin proteasome system (UPS), non-lysosomal protein degradation machinery mediate PQC cells. USPs regulate stability activity target proteins that involve intracellular signaling, transcriptional inflammation, antioxidation, cell growth. Recent studies demonstrate can fibrosis, lipid metabolism, glucose homeostasis, hypertrophic response, post-ischemic recovery death such apoptosis ferroptosis cardiomyocytes. Since myocardial loss an important cardiomyopathy, therefore, these findings suggest UPSs play emerging roles cardiomyopathy. This review briefly summarizes recent literature on regulatory occurrence development giving us new insights into molecular mechanisms different cardiomyopathy potential preventive strategies for

Language: Английский

Citations

0
Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

Citations

2