Exploring food and medicine homology: potential implications for cancer treatment innovations

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(2)

Published: Jan. 1, 2025

The concept of food and medicine homology (FMH) is deeply embedded in traditional Chinese carries historical importance. recent rigorous definition FMH pertains to substances that exhibit both pharmacological nutritional functions, have active ingredients are fundamentally non-toxic appropriate for extended consumption. With the progression modern biotechnology, application this treating diseases has markedly expanded, its intrinsic mechanisms been examined detail. use cancer therapy, as either a primary treatment or an adjuvant paved way low-toxicity treatments. This commentary examines theoretical underpinnings, potential advantages, practical applications prevention, treatment, support enhancement. Advantages including low toxicity, long-term edibility, minimal adverse effects, high patient compliance discussed. Moreover, owing multicomponent multitarget characteristics, may provide novel opportunities therapy. Given lethality associated ethical implications, current research should prioritize fundamental studies investigating Concurrently, preliminary preclinical would be establish solid foundation subsequent clinical trials.

Language: Английский

---

Cross-Talk Between Tumor Cells and Stellate Cells Promotes Oncolytic VSV Activity in Intrahepatic Cholangiocarcinoma

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 514 - 514

Published: Feb. 4, 2025

As the mechanisms underlying tumorigenesis become better understood, dynamic roles of cellular components tumor microenvironment, and their cross-talk with cells, have come to light as key drivers disease progression emerged important targets new cancer therapies. In field oncolytic virus (OV) therapy, stromal cells been considered potential barriers viral spread, thus limiting replication therapeutic outcome. However, evidence indicates that intratumoral fibroblasts could support replication. We demonstrated in a rat model stromal-rich intrahepatic cholangiocarcinoma (CCA) vesicular stomatitis (VSV) can be localized within hepatic stellate (HSCs), addition when was applied via arterial infusion. Furthermore, VSV shown efficiently kill CCA activated HSCs, co-culture HSCs increased titers. Interestingly, this effect is also observed each cell type cultured alone conditioned medium other type, indicating secreted factors are at least partially responsible for phenomenon. Partial reduction sensitivity I interferons systems, providing possible mechanism Together, results indicate targeting provide an additional OV which, until now has not considered. these findings suggest potentially powerful agent tumors, such pancreatic cancer, both which very difficult treat conventional therapy poor prognosis.

Language: Английский

---

Impact of Surgical Resection After Induction Gemcitabine Plus S-1-Based Chemoradiotherapy in Patients with Locally Advanced Pancreatic Ductal Adenocarcinoma: A Focus on UR-LA Cases

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 1048 - 1048

Published: March 20, 2025

Background: This study aimed to assess the safety and efficacy of gemcitabine plus S-1-based chemoradiotherapy (GS-CRT) among patients with locally advanced pancreatic ductal adenocarcinoma (PDAC), especially those unresectable (UR-LA) cases. Methods: A total 351 consecutive PDAC were enrolled prognostic predictors disease-specific survival (DSS) identified. Results: The treatment completion rate was 98.9% Grade 3 or higher adverse events occurred in 181 cases (51.6%). Among 319 re-evaluated patients, pancreatectomy performed 184 (57.7%). Based on resectability, 5-year DSS rates for entire cohort 39.6% (R), 43.8% (BR-PV), 21.2% (BR-A) 13.3% (UR-LA), while performance status (PS), hemoglobin (Hb) level, celiac artery (CA) involvement ≥180 degrees JPS 8th T category. In resected cases, preoperative PS, CA19-9 JPS-T factor, degree histological response adjuvant chemotherapy. UR-LA nutritional index (PNI), absence pathological venous invasion chemotherapy DSS. Conclusions: Even though encountered about half they uneventfully managed. Therefore, GS-CRT is safe highly tolerable potential improve patients‘ prognosis. Preoperative levels are important factors, as well therapy. (PNI) curative intent surgery.

Language: Английский

---

Inducing Targeted, Caspase-Independent Apoptosis with New Chimeric Proteins for Treatment of Solid Cancers

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1179 - 1179

Published: March 31, 2025

Background: Most newly developed anticancer treatments trigger tumor cell death through apoptosis, for which involvement of caspases activity is essential. However, numerous mutations in apoptotic pathways that lead to cancer and favor resistance apoptosis are known; most related caspase-dependent thus have low efficacy. To overcome these limitations, we constructed a novel chimeric protein, GnRH-AIF, using gonadotropin-releasing hormone (GnRH) analog as targeting moiety the apoptosis-inducing factor (AIF) its cleaved form killing moiety, fused at cDNA level. AIF has crucial role caspase-independent pathway. A wide variety solid tumors overexpress GnRH-receptors (GnRH-R) targeted by new GnRH-AIF protein. Methods Results: In this study, constructed, expressed, highly purified proteins. We demonstrated ability chimera enter specifically very efficiently kill lines overexpressing GnRH-R. importantly, upon entry, GnRH-AIFs translocate nucleus where it causes DNA fragmentation leading direct death. As AIFs lack nuclease activity, our findings also emphasize induced dependent on presence ENDOG PPIA proteins, known participate formation DNA-degradosome complex. Finally, high anti-tumor efficacy ex vivo, human, colon organoid model. Conclusions: Our study shows potential protein approach treat cancers GnRH-R, via

Language: Английский

---

Deficiency of MTAP Is Frequent and Mostly Homogeneous in Pancreatic Ductal Adenocarcinomas

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1205 - 1205

Published: April 1, 2025

The complete loss of S-methyl-5'-thioadenosine phosphorylase (MTAP) expression, often due to homozygous 9p21 deletion, creates a druggable vulnerability in cancer cells. A total 769 primary pancreatic ductal adenocarcinomas were analyzed on tissue microarrays with MTAP immunohistochemistry (IHC) and fluorescence situ hybridization (FISH). Intratumoral heterogeneity was assessed "heterogeneity" TMA containing up nine samples from different areas 236 tumor nodal metastases, whole sections all blocks 19 cancers. expression found 181 (37.9%) 478 interpretable tumors unrelated pT, pN, grade, size. homogenous 37.6% heterogeneous 1.1% the tumors, at least three evaluable TMA. On sections, 1 showed loss. correlation between IHC FISH nearly perfect, 98.8% MTAP-deficient showing deletion. is frequent, caused by mostly homogeneous adenocarcinomas. Considering also their aggressive clinical behavior, may represent an ideal type for studying new drugs targeting cells trials.

Language: Английский

---