International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13689 - 13689

Published: Dec. 21, 2024

Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression therapy. NLRP3-mediated immune response pyroptosis could be helpful or harmful cancer, depend on nature tumor microenvironment. The activation increase surveillance efficacy immunotherapy. It can lead to removal cells by recruitment phagocytic macrophages, T-lymphocytes, other site. On hand, harmful, as chronic inflammation driven supports creating an environment that facilitates cell proliferation, migration, invasion, metastasis. release pro-inflammatory cytokines such IL-1β IL-18 promote growth angiogenesis, while sustained may suppression, hindering effective anti-tumor responses. In this review article, we discuss role inflammasome-mediated pathophysiology types; understanding is essential for development innovative therapeutic strategies spread.

Language: Английский