Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137421 - 137421
Published: March 1, 2025
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117814 - 117814
Published: Jan. 13, 2025
Language: Английский
Citations
2
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 68 - 81
Published: Feb. 4, 2025
Language: Английский
Citations
1
Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 8, 2025
Ecotoxicology is essential for the evaluation and comprehension of effects emergency pollutants (EP) such as heavy metal ions on natural environment. EPs pose a substantial threat to health humans proper functioning global ecosystem. The primary concern exposure animals through contaminated water. presence in drinking water ought be monitored accordance with World Health Organization regulations. Among numerous harmful ions, copper are responsible variety human diseases. This study investigates application phage display screening method toxicological targets, served main focus. To identify Cu-binding M13 clones unique peptides assess their affinity utilized Escherichia coli factories producing recombinant bacteriophages, modified biopanning procedure an ELISA assay. research highlights increasing importance tool ecotoxicology. We synthesized selected peptide enable rapid optical detection Cu(II) aqueous solutions. By incorporating dansyl group into designated sequence, we implemented fluorescence assays real-time measurements. Cu2+- binding peptide's efficacy was confirmed spectroscopic measurements, which allowed response times high selectivity. technique successfully applied develop fluorescent peptide-based chemosensor that exhibited selectivity sensitivity Cu2+.
Language: Английский
Citations
0
Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111394 - 111394
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114299 - 114299
Published: Feb. 16, 2025
Language: Английский
Citations
0
The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(6)
Published: March 13, 2025
Abstract Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress inflammation within the liver. However, its specific role mitigating copper‐induced hepatic cuproptosis disturbances copper metabolism remains unexplored. Consequently, this research aims to investigate examine impact of spermidine related metabolism. In study, we established a model liver toxicity by feeding C57BL/6 mice high‐copper diet for three months. Histopathological biochemical analyses revealed that induced inflammatory cell infiltration, hepatocyte degeneration, elevated levels MDA, ROS, Cu 2+ accumulation liver, increased ALT AST activities serum ( p < .05). Regarding inflammation, significantly IL‐1β, IL‐6, TNF‐α .05), upregulated IFN‐γ expression, downregulated IL‐10 expression Meanwhile, inhibited Fe‐S cluster‐related proteins Exogenous administration effectively reduced while also decreasing activites, .001). Additionally, combined with CuSO 4 treatment promotes proteins, compared group summary, reduces alleviates cuproptosis, damage, exerts protective effect
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137421 - 137421
Published: March 1, 2025
Language: Английский
Citations
0