The Primary Cilia are Associated with the Axon Initial Segment in Neurons DOI Creative Commons
Han Wang, Yu Li, Xin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract The primary cilia serve as pivotal mediators of environmental signals and play crucial roles in neuronal responses. Disruption ciliary function has been implicated circuit disorders aberrant excitability. However, the precise mechanisms remain elusive. To study link between excitability, manipulation somatostatin receptor 3 (SSTR3) is investigated, an example how alterations signaling may affect activity. It found that SSTR3 expression perturbed not only morphology but also disrupted cascades. Genetic deletion resulted spatial memory synaptic plasticity. axon initial segment (AIS) a specialized region where action potentials are initiated. Interestingly, loss led to decrease Akt‐dependent cyclic AMP‐response element binding protein (CREB)‐mediated transcription at AIS, specifically downregulating AIS master organizer adaptor ankyrin G (AnkG) expression. In addition, other proteins serotonin 6 (5‐HT6R)and intraflagellar transport 88 (IFT88) induced length changes AIS. findings elucidate specific interaction providing insight into impact on excitability integrity.

Language: Английский

The Primary Cilia are Associated with the Axon Initial Segment in Neurons DOI Creative Commons
Han Wang, Yu Li, Xin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract The primary cilia serve as pivotal mediators of environmental signals and play crucial roles in neuronal responses. Disruption ciliary function has been implicated circuit disorders aberrant excitability. However, the precise mechanisms remain elusive. To study link between excitability, manipulation somatostatin receptor 3 (SSTR3) is investigated, an example how alterations signaling may affect activity. It found that SSTR3 expression perturbed not only morphology but also disrupted cascades. Genetic deletion resulted spatial memory synaptic plasticity. axon initial segment (AIS) a specialized region where action potentials are initiated. Interestingly, loss led to decrease Akt‐dependent cyclic AMP‐response element binding protein (CREB)‐mediated transcription at AIS, specifically downregulating AIS master organizer adaptor ankyrin G (AnkG) expression. In addition, other proteins serotonin 6 (5‐HT6R)and intraflagellar transport 88 (IFT88) induced length changes AIS. findings elucidate specific interaction providing insight into impact on excitability integrity.

Language: Английский

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