Discovery of biological markers for schizophrenia based on metabolomics: a systematic review DOI Creative Commons

Gaolei Yao,

Jingchun Zeng, Yuan Huang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

To discover biomarkers for schizophrenia (SCZ) at the metabolomics level, we registered this systematic review (CRD42024572133 (https://www.crd.york.ac.uk/PROSPERO/home)) including 56 qualified articles, and identified characteristics of metabolites, metabolite combinations, metabolic pathways associated with SCZ. Our findings showed that decreased arachidonic acid, arginine, aspartate levels, increased levels glucose 6-phosphate glycylglycine were onset Metabolites such as carnitine methionine sulfoxide not only helped to identify SCZ in Miao patients, but also different between patients Han patients. The decrease benzoic acid betaine increase creatine notable first-episode (FESCZ). combination formed by metabolites methylamine, dimethylamine other had best diagnostic effect. Arginine proline metabolism arginine biosynthesis a clear advantage identifying acute Butanoate played an important role SCZ, toxoplasma infection comorbidity. Biosynthesis unsaturated fatty acids was significantly enriched diagnosis treatment This study summarizes current progress clinical metabolomic research related deepens understanding pathogenesis lays foundation subsequent on SCZ-related metabolites. https://www.crd.york.ac.uk/PROSPERO/home, identifier CRD42024572133.

Language: Английский

Discovery of biological markers for schizophrenia based on metabolomics: a systematic review DOI Creative Commons

Gaolei Yao,

Jingchun Zeng, Yuan Huang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

To discover biomarkers for schizophrenia (SCZ) at the metabolomics level, we registered this systematic review (CRD42024572133 (https://www.crd.york.ac.uk/PROSPERO/home)) including 56 qualified articles, and identified characteristics of metabolites, metabolite combinations, metabolic pathways associated with SCZ. Our findings showed that decreased arachidonic acid, arginine, aspartate levels, increased levels glucose 6-phosphate glycylglycine were onset Metabolites such as carnitine methionine sulfoxide not only helped to identify SCZ in Miao patients, but also different between patients Han patients. The decrease benzoic acid betaine increase creatine notable first-episode (FESCZ). combination formed by metabolites methylamine, dimethylamine other had best diagnostic effect. Arginine proline metabolism arginine biosynthesis a clear advantage identifying acute Butanoate played an important role SCZ, toxoplasma infection comorbidity. Biosynthesis unsaturated fatty acids was significantly enriched diagnosis treatment This study summarizes current progress clinical metabolomic research related deepens understanding pathogenesis lays foundation subsequent on SCZ-related metabolites. https://www.crd.york.ac.uk/PROSPERO/home, identifier CRD42024572133.

Language: Английский

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