Individualized brain mapping for navigated neuromodulation DOI Creative Commons

Chaohong Gao,

Xia Wu,

Xinle Cheng

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: 137(5), P. 508 - 523

Published: Jan. 24, 2024

Abstract The brain is a complex organ that requires precise mapping to understand its structure and function. Brain atlases provide powerful tool for studying circuits, discovering biological markers early diagnosis, developing personalized treatments neuropsychiatric disorders. Neuromodulation techniques, such as transcranial magnetic stimulation deep stimulation, have revolutionized clinical therapies However, the lack of fine-scale limits precision effectiveness these techniques. Advances in neuroimaging machine learning techniques led emergence stereotactic-assisted neurosurgery navigation systems. Still, individual variability among patients diversity diseases make it necessary develop solutions. article provides an overview recent advances individualized navigated neuromodulation discusses methodological profiles, advantages, disadvantages, future trends concludes by posing open questions about development neuromodulation.

Language: Английский

Emerging regenerative medicine and tissue engineering strategies for Parkinson’s disease DOI Creative Commons
James P. Harris, Justin C. Burrell, Laura A. Struzyna

et al.

npj Parkinson s Disease, Journal Year: 2020, Volume and Issue: 6(1)

Published: Jan. 8, 2020

Abstract Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, affecting 1–2% of people over 65. The classic motor symptoms PD result from selective degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc), resulting a loss their long axonal projections to striatum. Current treatment strategies such as dopamine replacement and deep brain stimulation (DBS) can only minimize nigrostriatal degeneration, not directly replace lost pathway. Regenerative medicine-based solutions are being aggressively pursued with goal restoring levels striatum, several emerging techniques attempting reconstruct entire pathway—a key recreate feedback pathways ensure proper regulation. Although many pharmacological, genetic, optogenetic treatments developed, this article focuses on evolution transplant therapies for PD, including fetal grafts, cell-based implants, more recent tissue-engineered constructs. Attention given cell/tissue sources, efficacy date, future challenges that must be overcome enable robust translation into clinical use. Emerging regenerative medicine developed using derived autologous stem cells, enabling construction patient-specific constructs tailored particular extent degeneration. In upcoming era restorative neurosurgery, may SNpc neurons, restore axon-based inputs ameliorate deficits. These provide transformative scalable solution permanently neuroanatomy improve lives millions afflicted by PD.

Language: Английский

Citations

66
Acute effects of adaptive Deep Brain Stimulation in Parkinson’s disease DOI Creative Commons
Dan Piña‐Fuentes, J. Marc C. van Dijk, Jonathan C. van Zijl

et al.

Brain stimulation, Journal Year: 2020, Volume and Issue: 13(6), P. 1507 - 1516

Published: July 29, 2020

BackgroundBeta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when assessed the immediate post-implantation phase. However, potential benefits of aDBS patients with electrodes chronically implanted, whom changes due to microlesion effect have disappeared, are yet be assessed.MethodsTo determine acute effectiveness and side-effect profile PD compared conventional continuous DBS (cDBS) no stimulation (NoStim), years after implantation, 13 undergoing battery replacement were pseudo-randomised a crossover fashion, into three conditions (NoStim, or cDBS), 2-min interval between them. Patient videos blindly evaluated using short version Unified Disease Rating Scale (subUPDRS), Speech Intelligibility Test (SIT).ResultsMean duration was 16 years, mean time since DBS-implantation 6.9 years. subUPDRS scores (11 tested) significantly lower both (p=<.001), cDBS (p = .001), NoStim. Bradykinesia subscores .002), did not achieve significance during .08), Two demonstrated re-emerging tremor aDBS. SIT who presented stimulation-induced dysarthria worsened .009), but .407), Overall, applied 48.8% aDBS.ConclusionBeta-based bradykinetic phenotypes, delivers less than cDBS, potentially has more favourable speech profile. Patients prominent may require modified strategy.

Language: Английский

Citations

62
StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson’s Disease DOI
Angela M. Noecker, Anneke M. Frankemolle‐Gilbert, Bryan Lad Howell

et al.

Neuromodulation Technology at the Neural Interface, Journal Year: 2021, Volume and Issue: 24(2), P. 248 - 258

Published: Jan. 3, 2021

Language: Английский

Citations

45
Focused Ultrasound (FUS) for Chronic Pain Management: Approved and Potential Applications DOI Creative Commons
Lazzaro di Biase, Emma Falato, Maria Letizia Caminiti

et al.

Neurology Research International, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 16

Published: June 29, 2021

Chronic pain is one of the leading causes disability and disease burden worldwide, accounting for a prevalence between 6.9% 10% in general population. Pharmacotherapy alone results ineffective about 70-60% patients terms satisfactory degree relief. Focused ultrasound promising tool chronic management, being approved thalamotomy neuropathic bone metastases-related treatment. FUS noninvasive technique neuromodulation tissue ablation that can be applied to several tissues. Transcranial (tFUS) lead opposite biological effects, depending on stimulation parameters: from reversible neural activity facilitation or suppression (low-intensity, low-frequency ultrasound, LILFUS) irreversible (high-intensity focused ultrasounds, HIFU). HIFU at central nervous system level treatment facet joint osteoarthritis peripheral level. Potential applications include spinal cord selected cases refractory pain, knee osteoarthritis, sacroiliac disease, intervertebral disc nucleolysis, phantom limb, nerves. nonablative dosage, LILFUS, has potential tissue-selective effects. doses currently are research stage. The main targeted drug gene delivery through Blood-Brain Barrier, assessment thresholds study nerve conduction block. aim present review describe technology field management.

Language: Английский

Citations

44
Complications After Deep Brain Stimulation: A 21-Year Experience in 426 Patients DOI Creative Commons
In‐Ho Jung, Kyung Won Chang, Sohee Park

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: April 7, 2022

Deep brain stimulation is an established treatment for movement disorders such as Parkinson's disease, essential tremor, and dystonia. However, various complications that occur after deep are a major concern patients neurosurgeons.This study aimed to analyze stimulation.We reviewed the medical records of with disorder who underwent bilateral between 2000 2020. Among them, requiring revision surgery were analyzed.A total 426 disorder. The primary disease was in 315 patients, followed by dystonia 71 tremor 40 patients. Twenty-six (6.1%) had surgery; most common complication infection (12 2.8%).Various may stimulation, patient prognosis should be improved reducing complications.

Language: Английский

Citations

33
From Prodromal Stages to Clinical Trials: The Promise of Digital Speech Biomarkers in Parkinson's Disease DOI Creative Commons
Jan Rusz, Paul Krack, Elina Tripoliti

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 167, P. 105922 - 105922

Published: Oct. 18, 2024

Language: Английский

Citations

8
Machine learning and wearable sensors for automated Parkinson’s disease diagnosis aid: a systematic review DOI
Lazzaro di Biase, Pasquale Maria Pecoraro, Giovanni Pecoraro

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(10), P. 6452 - 6470

Published: Aug. 14, 2024

Language: Английский

Citations

7
OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling DOI Creative Commons
Konstantin Butenko, Christian Bahls, Max Schröder

et al.

PLoS Computational Biology, Journal Year: 2020, Volume and Issue: 16(7), P. e1008023 - e1008023

Published: July 6, 2020

In this study, we propose a new open-source simulation platform that comprises computer-aided design and engineering tools for highly automated evaluation of electric field distribution neural activation during Deep Brain Stimulation (DBS). It will be shown how Volume Conductor Model (VCM) is constructed examined using Python-controlled algorithms generation, discretization adaptive mesh refinement the computational domain, as well incorporation heterogeneous anisotropic properties tissue allocation neuron models. The utilization facilitated by collection predefined input setups quick visualization routines. accuracy VCM, created optimized platform, was estimated comparison with commercial software. results demonstrate no significant deviation between models in potential distribution. A qualitative estimation different physics VCM shows an agreement previous studies. proposed suitable accurate fields DBS scientific modeling future, intend to acquire SDA EMA approval. Successful software, controlled in-house developed algorithms, provides solution. allows optimization uncertainty quantification (UQ) studies, while employment software facilitates accessibility reproducibility simulations.

Language: Английский

Citations

46
Treatment of tics associated with Tourette syndrome DOI

Joseph Jankovic

Journal of Neural Transmission, Journal Year: 2020, Volume and Issue: 127(5), P. 843 - 850

Published: Jan. 18, 2020

Language: Английский

Citations

41
Changing Gears – DBS For Dopaminergic Desensitization in Parkinson's Disease? DOI
Daniel Weiß, Jens Volkmann, Alfonso Fasano

et al.

Annals of Neurology, Journal Year: 2021, Volume and Issue: 90(5), P. 699 - 710

Published: July 8, 2021

In Parkinson's disease, both motor and neuropsychiatric complications unfold as a consequence of incremental striatal dopaminergic denervation intensifying long-term treatment. Together, this leads to 'dopaminergic sensitization' steadily increasing behavioral responses medication that result in the detrimental sequalae We review clinical presentations sensitization', including rebound off dyskinesia domain, fluctuations addictions with impulse control disorders dopamine dysregulation syndrome domain. summarize state-of-the-art deep brain stimulation, show STN-DBS allows be tapered, thus supporting desensitization. framework, we develop our integrated debatable viewpoint "changing gears", is suggest rethinking earlier use subthalamic nucleus when first signs or emerge over progressive disease course. sense, stimulation may help reduce longitudinal symptom expression - importantly, not by neuroprotection but desensitization through postoperative reduction. Therefore, considering early enough before patients encounter potentially irreversible psychosocial consequences complications, importantly patient shows complications. propose consider new inclusion criterion addition established criteria, concept will require validation future trials. ANN NEUROL 2021;90:699-710.

Language: Английский

Citations

40