Movement Disorders, Journal Year: 2023, Volume and Issue: 38(8)
Published: Aug. 1, 2023
Language: Английский
JAMA Neurology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 21, 2024
Importance The risk of developing Parkinson disease (PD) after objective hearing loss is unknown. PD studies using self-reported are insensitive, and data lacking. Objective To examine the association with incident in US veterans its effect modification by well-established prodromal conditions aids. Design, Setting, Participants This cohort study analyzed electronic health record from Department Veterans Affairs for who had an audiogram January 1, 1999, to December 30, 2022. Individuals missing or a preexisting diagnosis were excluded. Exposure Audiogram-confirmed loss. Main Outcomes Measures Cumulative incidence was calculated adjustment competing death. Results Among 7 296 051 audiogram, 3 596 365 included. They mostly male (n = 452 898 [96%]) mean (SD) age 67 (10.3) years. A total 750 010 individuals (20.8%) normal at time audiometry examination; among those loss, 1 080 651 (30.0%), 039 785 (28.9%), 568 (15.8%), 157 623 (4.3%) mild (20-<35 dB), moderate (35-<50 severe (50-<65 profound (65-120 dB) respectively. Age, gender, smoking history balanced between all exposed unexposed groups further race, ethnicity, frailty. At 10 years baseline numbers additional cases 6.1 (95% CI, 4.5-7.79, 15.8 12.8-18.8), 16.2 11.9-20.6), 12.1 4.5-19.6) mild, moderate, severe, respectively, compared hearing. When combined established conditions, associated 5.7 2.2-9.2) either condition alone. With prompt aid dispensation, decreased 21.6 19.5-23.6) Conclusions Relevance Hearing appears be independent factor later development PD. aids attenuate this risk, therefore widespread screening appropriate use may reduce Additional needed mechanisms underlying
Language: Английский
Citations
4
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Abstract Development of Parkinson’s Disease (PD) is linked with a history traumatic brain injury (TBI), although the mechanisms driving this remain unclear. Of note, many key parallels have been identified between pathologies PD and TBI; in particular, characterised by loss dopaminergic neurons from substantia nigra (SN), accompanied broader changes to signalling, disruption Locus Coeruleus (LC) noradrenergic system, accumulation aggregated α-synuclein Lewy Bodies, which spreads stereotypical pattern throughout brain. Widespread disruptions systems, including progressive neuronal SN LC, observed acutely following injury, some also chronically TBI patients preclinical models . Furthermore, expression are seen both brain, detailed characterisation these spread pathology limited. In review, we detail current literature regarding particular focus on how may predispose individuals prolonged neurodegeneration, particularly development PD. While it increasingly clear that risk factor for PD, significant gaps understanding neurodegenerative TBI, chronic manifestations injury.
Language: Английский
Citations
0
Journal of Sleep Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related severity more neurological features indicative prodromal synucleinopathy compared to only. An early sign neurodegenerative condition is autonomic dysfunction, which we sought evaluate examining heart rate variability during sleep. Participants overnight polysomnography were recruited from the Veterans Affairs Portland Health Care System. without NT or (controls, n = 19), only (RBD, 14), (RBD+NT, 19) evaluated. Eligible 5-min non-REM (NREM) REM epochs apneas/hypopneas, microarousals, ectopic beats analysed for frequency time domain (e.g., low-frequency [LF] power; high-frequency [HF] root mean square successive R-R intervals [RMSSD]; percentage that vary ≥50 ms [pNN50]) outcomes. Heart did not significantly differ between groups in any stage. Time variables LF power, HF RMSSD, pNN50) reduced RBD+NT group controls RBD-only NREM There no differences detected These data suggest significant reductions participants, suggesting greater dysfunction alone. may be early, promising biomarker, yielding mechanistic insight diagnosis prognosis neurodegeneration this vulnerable population.
Language: Английский
Citations
0
Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
0
Neurochemistry International, Journal Year: 2024, Volume and Issue: 180, P. 105874 - 105874
Published: Oct. 2, 2024
Language: Английский
Citations
3
Clinical Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 10, P. 100253 - 100253
Published: Jan. 1, 2024
The research criteria for prodromal Parkinson disease (pPD) depends on prospectively validated clinical inputs with large effect sizes and/or high prevalence. Neither traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), nor chronic pain are currently included in the calculator, despite recent evidence of association pPD. These conditions widely prevalent, co-occurring, and already known to confer risk REM behavior (RBD) PD. Few studies have examined PD context TBI PTSD; none pain. This study aimed measure pPD caused by TBI, PTSD, 216 US Veterans were enrolled who had self-reported recurrent or persistent at least three months. Of these, 44 met 39 41 all conditions. Several pain, sleep, affective, trauma questionnaires administered. Participants' history RBD was determined via self-report, a subset undergoing confirmatory video polysomnography. A greater proportion (36 % vs. 10 %) (18.0 8.3 compared controls. Proportions increased (70 (27 when co-occurred PTSD. Partial effects seen just PTSD alone. When analyzed as continuous variables, polytrauma symptom severity correlated probability (r = 0.28, P 0.03). data demonstrate potential utility prediction pPD, importance trauma-related factors pathogenesis
Language: Английский
Citations
1
Movement Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
Abstract Background Electronic medical record (EMR)–based studies hold great potential for epidemiologic investigations of Parkinson's disease (PD) causal factors and phenomenology, but diagnostic misclassification may obscure or bias inferences. Objectives The aims were to determine the validity PD codes in Veterans Administration (VA) national electronic databases develop recommendations maximizing ascertainment accuracy. Methods We investigated a cohort 146,776 veterans who utilized VA healthcare between 1999 2021. reviewed records individuals with International Classification Diseases (ICD) code outpatient, inpatient, community care encounters assign gold‐standard diagnosis. determined accuracy based on provider type, coding frequency, medications, potentially exclusionary ICD overall by race. Results A total 377 810 (46.5%) had PD. whose was coded PD‐specialist neurologist most likely have (83.6%), sensitivity low (15.0%). Diagnostic decreased any (66.9%), improved (69.4%). Requiring two more combination levodopa prescriptions accuracy, particularly among nonneurologists. Neuroleptic‐induced parkinsonism frequent diagnosis those without (15.6%). Accuracy lower Black (29.0%) than White (50.5%) regardless type (miscoding odds ratio 2.5, 95% confidence interval 1.7–3.6). Conclusions These results highlight limitations EMR‐based ascertainment. Researchers can maximize considering specialty, pharmacy data, diagnoses, some degree review is required ensure high Higher miscoding warrants further study. © 2024 Author(s). Movement Disorders published Wiley Periodicals LLC behalf Parkinson Disorder Society. This article has been contributed U.S. Government employees their work public domain USA.
Language: Английский
Citations
1
Published: Jan. 1, 2024
Background: Parkinson's disease (PD) is a heterogeneous with many non-motor manifestations that often precede motor symptom onset. While other sensory disturbances such as loss of sense smell or visual problems have been well-characterized, it unknown how hearing may influence PD incidence.Methods: We undertook large Electronic Health Record-based cohort study over 3 million US military Veterans objective audiogram data. Stratifying by severity, we determined cumulative incidence in each stratum. also analyzed this varied when combined several known comorbid conditions and receiving aid.Findings: Our major finding loss, defined pure tone audiometry, associated significant increased risk developing later life dose-dependent manner, worse more risk. Moreover, found synergized prodromal disorders constipation, resulting greater-than-additive incident they co-occurred. Additionally, report dispensing aid following an abnormal attenuated the observed PD. The Number Needed to Treat was estimated at 462 10 years after audiogram, striking effect given high prevalence low PD.Interpretation: Hearing appears be independent factor for development aids attenuate risk, therefore widespread screening appropriate use reduce PD.Funding: This work supported VA BLR&D CDA2 IK2 BX005760-01A1, John Tami Marick Family Foundation, Collins Medical Trust Award, OHSU MRF New Investigator PCO Pilot Award (to G.D.S.), CSR&D CX00253-01A1 L.E.N.).This National Center Rehabilitative Auditory Research (Center #C2361C/I50 RX002361) Disease Research, Education, Clinical Portland Care System. acknowledge assistance Oregon & Translational Institute, which through Grant UL1TR002369.Declaration Interest: declare no competing interests.Ethical Approval: Data were obtained from Administration under institution review board approval (MIRB #04744) using waiver participant consent. All time periods available within Corporate Warehouse (CDW) included study. followed Strengthening Reporting Observational Studies Epidemiology (STROBE) reporting guidelines.
Language: Английский
Citations
0
Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(6), P. 1265 - 1269
Published: Aug. 20, 2024
Post-traumatic stress disorder (PTSD) may be a risk factor for Parkinson's disease (PD). We examined the relation between PTSD and PD in cohort of 158,122 Veterans who had any Health Administration (VHA) or Medicare health care utilization 10/1/1999- 2/17/2021. Using nested case-control design we matched 10 controls to each Veteran with by sex, race, rank. In conditional logistic regression models adjusted camp smoking, diagnosis was significantly associated (OR = 1.35; p 0.0002); odds were higher if coded before 1.53, < 0.0001). PD.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 24, 2024
Individuals with comorbid REM sleep behavior disorder (RBD) and neurotrauma (defined by traumatic brain injury post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related severity more neurological features indicative prodromal synucleinopathy compared to only. An early sign neurodegenerative condition is autonomic dysfunction, which we sought evaluate examining heart rate variability during sleep. Participants overnight polysomnography were recruited from the VA Portland Health Care System. Veterans without or (controls; n=19), only (RBD, n=14), (RBD+NT, n=19) evaluated. Eligible 5-minute NREM epochs apneas/hypopneas, microarousals, ectopic beats analyzed for frequency time domain (e.g. low power, LF; high HF; root mean square successive RR intervals, RMSSD; % intervals that vary ≥50 ms, pNN50) outcomes. Heart did not significantly differ between groups in any stage. Time variables (e.g., LF HF RMSSD, reduced RBD+NT controls There no group differences detected These data suggest significant reductions participants, suggesting greater dysfunction alone. may be early, promising biomarker, yielding mechanistic insight diagnosis prognosis neurodegeneration this vulnerable population.
Language: Английский
Citations
0