Nanoplastics induces oxidative stress and triggers lysosome-associated immune-defensive cell death in the earthworm Eisenia fetida DOI Creative Commons
Yanfei Zhou, Gang He, Hao Jiang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 174, P. 107899 - 107899

Published: March 27, 2023

Nanoplastics (NPs) are increasingly perceived as an emerging threat to terrestrial environments, but the adverse impacts of NPs on soil fauna and mechanisms behind these negative outcomes remain elusive. Here, a risk assessment was conducted model organism (earthworm) from tissue cell. Using palladium-doped polystyrene NPs, we quantitatively measured nanoplastic accumulation in earthworm investigated its toxic effects by combining physiological with RNA-Seq transcriptomic analyses. After 42-day exposure, accumulated up 15.9 143.3 mg kg-1 for low (0.3 kg-1) high (3 dose groups, respectively. retention led decrease antioxidant enzyme activity reactive oxygen species (O2- H2O2), which reduced growth rate 21.3 %-50.8 % caused pathological abnormalities. These were enhanced positively charged NPs. Furthermore, observed that irrespective surface charge, after 2 h gradually internalized coelomocytes (∼0.12 μg per cell) mainly amassed at lysosomes. Those agglomerations stimulated lysosomal membranes lose stability even rupture, resulting impeded autophagy process cellular clearance, eventually coelomocyte death. In comparison negatively nanoplastics, exerted 83 higher cytotoxicity. Our findings provide better understanding how posed harmful have important implications evaluating ecological

Language: Английский

Oxidative stress, inflammation and hormesis: The role of dietary and lifestyle modifications on aging DOI
Vinita Sharma, Mohammad Murtaza Mehdi

Neurochemistry International, Journal Year: 2023, Volume and Issue: 164, P. 105490 - 105490

Published: Jan. 24, 2023

Language: Английский

Citations

60
ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries DOI Open Access

Bowen Jia,

Jing Li, Yiting Song

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10021 - 10021

Published: June 12, 2023

As an iron-dependent regulated form of cell death, ferroptosis is characterized by lipid peroxidation and has been implicated in the occurrence development various diseases, including nervous system diseases injuries. Ferroptosis become a potential target for intervention these or injuries relevant preclinical models. member Acyl-CoA synthetase long-chain family (ACSLs) that can convert saturated unsaturated fatty acids, Acyl—CoA familymember4 (ACSL4) involved regulation arachidonic acid eicosapentaenoic acid, thus leading to ferroptosis. The underlying molecular mechanisms ACSL4-mediated will promote additional treatment strategies injury conditions. Our review article provides current view ferroptosis, mainly structure function ACSL4, as well role ACSL4 We also summarize latest research progress central further proving ACSL4-medicated important

Language: Английский

Citations

46
Pb uptake, accumulation, and translocation in plants: Plant physiological, biochemical, and molecular response: A review DOI Creative Commons
Shafeeq Ur Rahman, Anzhen Qin, Muhammad Zain

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27724 - e27724

Published: March 1, 2024

Lead (Pb) is a highly toxic contaminant that ubiquitously present in the ecosystem and poses severe environmental issues, including hazards to soil-plant systems. This review focuses on uptake, accumulation, translocation of Pb metallic ions their toxicological effects plant morpho-physiological biochemical attributes. We highlight uptake metal controlled by cation exchange capacity, pH, size soil particles, root nature, other physio-chemical limitations. toxicity obstructs seed germination, root/shoot length, growth, final crop-yield. disrupts nutrient through roots, alters plasma membrane permeability, disturbs chloroplast ultrastructure triggers changes respiration as well transpiration activities, creates reactive oxygen species (ROS), activates some enzymatic non-enzymatic antioxidants. also impairs photosynthesis, water balance mineral nutrients, hormonal status, structure permeability. provides consolidated information concentrating current studies associated with Pb-induced oxidative stress conditions various plants, highlighting roles different antioxidants plants mitigating Pb-stress. Additionally, we discussed detoxification tolerance responses regulating gene expressions, protein, glutathione metabolisms resist phytotoxicity. Overall, approaches tackle have been addressed; phytoremediation techniques biochar amendments are economical eco-friendly remedies for improving Pb-contaminated soils.

Language: Английский

Citations

44
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases DOI Creative Commons
Yao Xiang, Xiaohua Song,

Dingxin Long

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(3), P. 579 - 615

Published: Jan. 24, 2024

Abstract This article provides an overview of the background knowledge ferroptosis in nervous system, as well key role nuclear factor E2-related 2 (Nrf2) regulating ferroptosis. The takes Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), and amyotrophic lateral sclerosis (ALS) starting point to explore close association between Nrf2 ferroptosis, which is clear significant importance for understanding mechanism neurodegenerative diseases (NDs) based on oxidative stress (OS). Accumulating evidence links pathogenesis NDs. As progresses, damage antioxidant excessive OS, altered expression levels, especially inhibition by lipid peroxidation inhibitors adaptive enhancement signaling, demonstrate potential clinical significance detecting identifying targeted therapy neuronal loss mitochondrial dysfunction. These findings provide new insights possibilities treatment prevention

Language: Английский

Citations

28
Edaravone-loaded poly(amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury DOI Creative Commons
Yunhan Zhang,

Zhulin Zou,

Shuang Liu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(2), P. 100886 - 100886

Published: Feb. 5, 2024

Neurological injury caused by ischemic stroke is a major cause of permanent disability and death. The currently available neuroprotective drugs fail to achieve desired therapeutic efficacy mainly due short circulation half-life poor blood−brain barrier (BBB) permeability. For that, an edaravone-loaded pH/glutathione (pH/GSH) dual-responsive poly(amino acid) nanogel (NG/EDA) was developed improve the neuroprotection EDA. triggered acidic EDA-induced high-level GSH microenvironments, which enabled selective sustained release EDA at site injury. NG/EDA exhibited uniform sub-spherical morphology with mean hydrodynamic diameter 112.3 ± 8.2 nm. efficiently accumulated cerebral middle artery occlusion (pMCAO) mice, showing efficient BBB crossing feature. Notably, 50 μM significantly increased neuron survival (29.3%) following oxygen glucose deprivation inhibiting ferroptosis. In addition, administering for 7 d reduced infarct volume 22.2% 7.2% decreased neurobehavioral scores from 9.0 0.6 2.0 0.8. Such pH/GSH nanoplatform might provide unique promising modality in other central nervous system diseases.

Language: Английский

Citations

25
Iron Metabolism and Ferroptosis in Epilepsy DOI Creative Commons
Shuang Chen,

Yongmin Chen,

Yukang Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Dec. 8, 2020

Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It diverse etiology, complex pathogenesis, difficult treatment. In addition, most epileptic patients exhibit social cognitive impairment psychological impairment. Iron essential trace element for human growth development also involved in variety redox reactions organisms. However, abnormal iron metabolism associated with several neurological disorders, including hemorrhagic post-stroke epilepsy post-traumatic (PTE). Moreover, ferroptosis considered new form regulation cell death, which attributed to severe lipid peroxidation caused the production reactive oxygen species (ROS) overload found various diseases, epilepsy. Therefore, this review summarizes study on epilepsy, order elucidate correlation between provides novel method treatment, prevention, research control seizures reduce nerve injury after seizure.

Language: Английский

Citations

91
Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies DOI Creative Commons
Snježana Petrović, Aleksandra Arsić, Danijela Ristić-Medić

et al.

Antioxidants, Journal Year: 2020, Volume and Issue: 9(11), P. 1128 - 1128

Published: Nov. 13, 2020

Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability morbidity elderly, imposing a significant economic social burden. As components central nervous system, lipids play important roles neural health pathology. Disturbed lipid metabolism, particularly peroxidation (LPO), is associated with development many NDDs, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), all which show elevated levels LPO products LPO-modified proteins. Thus, inhibition oxidation might slow progression reduce severity NDD; natural antioxidants, such as polyphenols antioxidant vitamins, seem to be most promising agents. Here, we summarize current literature data that were derived from human studies on effect vitamins A, C, E supplementation patients AD, PD, ALS. Although these compounds may NDD, research gaps remain antioxidants ALS patients, indicates further applying different forms NDDs urgently needed.

Language: Английский

Citations

89
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology DOI Creative Commons
Noemí Esteras, Andrey Y. Abramov

Cells, Journal Year: 2020, Volume and Issue: 9(9), P. 2135 - 2135

Published: Sept. 21, 2020

Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer’s disease (AD) other tauopathies including frontotemporal dementia (FTD). The interaction between oxidative stress, mitochondrial dysfunction impairment calcium ions (Ca2+) homeostasis induced by misfolded plays an important role progressive neuronal loss occurring specific areas brain. In addition to control bioenergetics ROS production, mitochondria fine regulators cytosolic Ca2+ that induce vital signalling mechanisms excitable cells neurons. Impairment uptake through uniporter (MCU) or release Na+/Ca2+ exchanger may lead overload opening permeability transition pore inducing death. Recent evidence suggests for these underlying causes death pathology. present review will focus on especially disturbances AD tau-induced FTD, propose possible therapeutic interventions disorders.

Language: Английский

Citations

86
Disentangling Mitochondria in Alzheimer’s Disease DOI Open Access
Ashu Johri

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11520 - 11520

Published: Oct. 26, 2021

Alzheimer’s disease (AD) is a major cause of dementia in older adults and fast becoming societal economic burden due to an increase life expectancy. Age seems be the factor driving AD, currently, only symptomatic treatments are available. AD has complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, metabolic abnormalities have been widely deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques hyperphosphorylated tau aggregates, along with cognitive deficits behavioral problems, hallmarks disease. Restoration bioenergetics, prevention diet exercise seem effective reducing ameliorating learning memory problems. Many mitochondria-targeted antioxidants tested currently development. However, larger streamlined clinical studies needed provide hard evidence benefits AD. This review discusses causative factors, well potential therapeutics employed treatment

Language: Английский

Citations

63
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation DOI Creative Commons
Dan Zhang,

Yikun Ren,

Yuanmeng He

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100278 - 100278

Published: May 10, 2022

The efficacy of neural repair and regeneration strategies for traumatic brain injury (TBI) treatment is greatly hampered by the harsh lesion microenvironment including oxidative stress hyper-inflammatory response. Functionalized hydrogel with capability suppression neuroinflammation inhibition will contribute to repairment TBI. Herein, antioxidant gallic acid-grafted hyaluronic acid (HGA) was combined acid-tyramine (HT) polymer develop an injectable dual-enzymatically crosslinking method. resulting HT/HGA biocompatible possesses effective scavenging activity against DPPH hydroxyl radicals. Meanwhile, this improved cell viability reduced intracellular reactive oxygen species (ROS) production under H2O2 insult. in vivo study showed that situ injection significantly malondialdehyde (MDA) increased glutathione (GSH) expression area after 3 or 21 days, which might be associated activation Nrf2/HO-1 pathway. Furthermore, promoted microglia polarization M2 (Arg1) phenotype, it also decreased level proinflammatory factors TNF-α IL-6 anti-inflammatory factor IL-4. Finally, blood-brain barrier (BBB) protected, neurogenesis hippocampus promoted, motor, learning memory ability enhanced. Therefore, injectable, biocompatible, exhibits a huge potential treating TBI allows us recognize great value novel biomaterial remodeling structure function.

Language: Английский

Citations

59