Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: March 2, 2022

Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over past few years, relevance between cellular senescence IVDD has been widely studied, senescence-associated secretory phenotype (SASP) produced by senescent cells found to remodel extracellular matrix (ECM) metabolism destruct homeostasis. Elimination senolytics suppression SASP production senomorphics/senostatics are effective strategies alleviate degenerative diseases including IVDD. Here, we review involvement in process IVDD; also discuss potential on eliminating alleviating finally, provide a table listing senolytic drugs small molecules, aiming propose for therapy future.

Language: Английский

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Banxia Xiexin decoction alleviates AS co-depression disease by regulating the gut microbiome-lipid metabolic axis

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 313, P. 116468 - 116468

Published: April 10, 2023

Banxia Xiexin decoction (BXD) is a classic Chinese herbal formulation consisting of 7 herbs including Pinelliae Rhizoma, Scutellariae Radix, Zingiberis Ginseng Glycyrrhizae Coptidis and Jujubae Fructus, which can exert effects on lowering lipids alleviating depressive mood disorders via affecting gastrointestinal tract.The pathogenesis atherosclerosis (AS) co-depression disease has not been well studied, the current clinical treatment strategies are satisfactory. As result, it critical to find novel methods treatment. Based hypothesis that gut microbiome may promote development AS by regulating host lipid metabolism, this study sought evaluate effectiveness action mechanism BXD in regulation an intervention mice.To determine primary constituents BXD, UPLC-Q/TOF-MS analysis was carried out. Sixteen C56BL/6 mice were fed normal chow as control group; 64 ApoE-/- randomized into four groups (model group three groups) high-fat combined with daily bind stimulation for sixteen weeks develop mouse model administered saline or low, medium high concentrations during experimental modeling period. The antidepressant efficacy examined weighing, sucrose preference test, open field tail suspension experiment. anti-AS evaluated means biochemical indices, HE staining method, Oil red O method. impacts structure brain (hippocampus prefrontal cortex tissue) 16S rDNA sequencing lipidomics analysis.The main components include baicalin, berberine, ginsenoside Rb1, 18 other substances. could improve depression-like behavioral characteristics AS-related indices mice; regulate abundance some flora (phylum level: reduced Proteobacteria Deferribacteres; genus Clostridium_IV, Helicobacter, Pseudoflavonifractor, Acetatifactor, Oscillibacter, significantly different). showed differential between gavaged high-dose (BXH) enriched glycerophospholipid lysophosphatidylcholine (LPC(20:3)(rep)(rep)) hippocampus LPC(20:4)(rep) both downregulation BXH. correlation illustrated screened mainly linked Deferribacteres Actinobacteria.BXD therapeutic effect modulating thus intervening peripheral metabolism (via LPC levels).

Language: Английский

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Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut–brain axis

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 306, P. 116158 - 116158

Published: Jan. 11, 2023

Language: Английский

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Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 310, P. 116367 - 116367

Published: March 12, 2023

Language: Английский

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Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117134 - 117134

Published: Sept. 14, 2023

Language: Английский

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