Synthesis of Ozonides Mediated by Molecular Sieve Under Solvent-Free Conditions DOI
Mohamed R. El-kholany,

Nana Kishimoto,

Kenta Tanaka

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 165, P. 134137 - 134137

Published: July 10, 2024

Language: Английский

Design, Synthesis, Molecular Docking, Drug-Likeness/ADMET and Molecular Dynamics Studies of Thiazolyl Benzenesulfonamide Carboxylates as Antimalarial Agents DOI
James A. Ezugwu, Uchechukwu C. Okoro, Mercy A. Ezeokonkwo

et al.

Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(5), P. 2353 - 2368

Published: March 5, 2024

Language: Английский

Citations

8
Endoperoxides as Antimalarials: Development, Structural Diversity, and Pharmacodynamic Aspects of 1,2,4,5-Tetraoxane-Based Structural Scaffolds DOI Creative Commons
Alka Agarwal, Upendra Kumar Patel,

Alka Ahuja

et al.

SynOpen, Journal Year: 2025, Volume and Issue: 09(01), P. 10 - 24

Published: Jan. 1, 2025

Abstract Malaria poses a serious threat to human life and is prevalent in tropical subtropical areas across the globe. Drugs such as quinine, chloroquine (a synthetic version of quinine), artemisinin, its derivative compounds have been used treat malaria. Developing highly effective chemical scaffolds with minimal toxicity necessary because malarial parasites become resistant existing drugs. In this context, 1,2,4,5-tetraoxanes emerged crucial framework notable antimalarial properties. To improve effectiveness combat resistance various drugs, combined variety alicyclic, aryl, heteroaryl, spiro groups including steroid-based, aminoquinoline-based, dispiro-based, triazine-based, diaryl-based, piperidine-based 1,2,4,5-tetraoxanes. We provide an overview synthesis most important vitro vivo investigations carried out on hybrids based 1,2,4,5-tetraoxane The future development malaria treatment may be influenced by structural changes different 1,2,4,5-tetraoxane. 1 Introduction 2 Synthetic Methods for Tetraoxanes 3 Antimalarial Activities Tetraoxane Derivatives 3.1 Cycloalkanone-Based 3.2 Steroid-Based 3.3 Adamantane-Based 3.4 Dispiro-Based 3.5 Diaryl-Based 3.6 Di-adamantane-Based 3.7 Benzylamino- Aryloxy-Based 3.8 Aminoquinoline-Based 3.9 2-Cyanopyrimidine-Based 4 Mannich Base Based 4.1 N-Sulfonylpiperidine-Based 4.2 N-Benzoylpiperidine-Based 5 Mechanism Action Dispiro-1,2,4,5-tetraoxanes 6 Conclusion

Language: Английский

Citations

0
Falcipain-2: A review on structurally diverse non-peptide inhibitors DOI
Vandana Pandey,

John F. Kennedy,

Neera Raghav

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142817 - 142817

Published: April 1, 2025

Language: Английский

Citations

0
Novel saturated 1,2,4-trioxanes and their antimalarial activity against multidrug resistant Plasmodium yoelii nigeriensis in Swiss mice model via oral route DOI
Akriti Kumari, Priyanka Yadav, Varun Rawat

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 108, P. 129801 - 129801

Published: May 20, 2024

Language: Английский

Citations

1
Endoperoxidases in biosynthesis of endoperoxide bonds DOI
Shaoshan Zhang,

Bin He,

Axiang Qu-Bie

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136806 - 136806

Published: Oct. 1, 2024

Language: Английский

Citations

1
FORMULATION AND CHARACTERIZATION OF GDL-BASED ARTESUNATE SOLID LIPID NANOPARTICLE DOI Open Access
ANAMIKA JAIN, Suresh P. Vyas

International Journal of Applied Pharmaceutics, Journal Year: 2023, Volume and Issue: unknown, P. 68 - 74

Published: Sept. 7, 2023

Objective: The present research aimed to prepare and characterize glyceryl dilaurate (GDL) containing solid lipid nanoparticles (SLN) with tween 80 lecithin as an emulsifier in which the artesunate drug was loaded. Methods: SLNs were synthesized by solvent emulsification–diffusion technique. formulation characterized for size, size distribution, zeta potential, shape morphology, DSC. In vitro release studies performed at pH 5.0 7.4 mimic vivo conditions. Hemolytic vitro, antiplasmodial activities carried out. Plasmodium berghei (NK65 resistant strain) infected mice used test antimalarial efficacy of SLN. Results: SLN exhibited 327 nm average sizes 0.164 PDI and-23.4 mV potential. TEM images revealed a spherical structure. entrapment efficiency ART calculated 85.68%. showed that entrapped released weakly acidic environment (83.45% ART). ART-GDL conjugate stable safe parenteral delivery. IC50 value GDL-based ART-SLNs be 0.32 µM. Furthermore, resulted enhanced parasite killing P. berghei-infected improved survivability compared free administration. Conclusion: allows effective intravenous administration artesunate. Thus GDL-Based could potential delivery system therapy.

Language: Английский

Citations

2
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes DOI
Komal Rathi,

Monika Shukla,

Mohammad Hassam

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 143, P. 107043 - 107043

Published: Dec. 19, 2023

Language: Английский

Citations

2
Synthesis of Ozonides Mediated by Molecular Sieve Under Solvent-Free Conditions DOI

Nana Kishimoto,

Kenta Tanaka, Hiroyoshi Takamura

et al.

Published: Jan. 1, 2024

An efficient method for the direct synthesis of ozonides via reaction alkenes with an ozone stream under solvent-free conditions is described. In this study, alkene substrates were loaded over a roughly ground molecular sieve and exposed to give corresponding ozonides. The new synthetic protocol was successfully applied various substituted in good yields.

Language: Английский

Citations

0
Synthesis of Ozonides Mediated by Molecular Sieve Under Solvent-Free Conditions DOI
Mohamed R. El-kholany,

Nana Kishimoto,

Kenta Tanaka

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 165, P. 134137 - 134137

Published: July 10, 2024

Language: Английский

Citations

0