Enfermedades Infecciosas y Microbiología Clínica, Journal Year: 2023, Volume and Issue: 42(2), P. 118 - 119
Published: Nov. 20, 2023
Language: Английский
Advances in Medical Sciences, Journal Year: 2024, Volume and Issue: 69(1), P. 36 - 50
Published: Feb. 8, 2024
Glycation is a physiological process that determines the aging of organism, while in states metabolic disorders it significantly intensified. High concentrations compounds such as reducing sugars or reactive aldehydes derived from lipid oxidation, occurring for example diabetes, atherosclerosis, dyslipidemia, obesity syndrome, lead to increased glycation proteins, lipids and nucleic acids. The level advanced end-products (AGEs) body depends on rapidity their production rate removal by urinary system. AGEs, accumulated extracellular matrix blood vessels other organs, cause irreversible changes biochemical biomechanical properties tissues. As consequence, micro- macroangiopathies appear system, may contribute organ failure, like kidneys heart. Elevated levels AGEs also increase risk Alzheimer's disease various cancers. In this paper, we propose new classification due modified amino acid residues: arginyl-AGEs, monolysyl-AGEs lysyl-arginyl-AGEs dilysyl-AGEs. Furthermore, describe detail effect pathogenesis old age diseases, diabetic complications, atherosclerosis neurodegenerative diseases. We summarize currently available data diagnostic value present therapeutic goal wide range medical problems, including SARS-CoV-2 infection so-called long COVID.
Language: Английский
Citations
10
Human Cell, Journal Year: 2025, Volume and Issue: 38(2)
Published: Jan. 3, 2025
Language: Английский
Citations
0
Advances in psychology, mental health, and behavioral studies (APMHBS) book series, Journal Year: 2025, Volume and Issue: unknown, P. 433 - 458
Published: Jan. 3, 2025
Neuropsychological disorders, such as dementia and other cognitive impairments, pose significant challenges not only to patients but also their caregivers. As the prevalence of these disorders increases globally, demand for caregiving support has escalated, highlighting critical role caregivers in managing both physical emotional needs affected individuals. This study explores health, mental behaviors, health indicators among caregivers, differentiating between high- low-intensity groups. The research employed a mixed-methods approach that included qualitative face-to-face interviews quantitative standardized questionnaires. involved 32 with an average age 68 years. main objectives were compare frequency intensity activities, assess caregivers' status, identify behaviors associated intensity.
Language: Английский
Citations
0
Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2025
Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based medicine. One most extensively studied biological pathways is gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies dysbiosis suggest complex behavioral changes, such as alterations sociability and anxiety, can be modulated through microbiota. Specifically, mental disorders include major depression, bipolar disorder, schizophrenia. Gastrointestinal diseases reversed by modulating Dementia its related mechanisms are also amenable modulation This review focuses on role microbiota dementia discussing effects depressive symptoms, cognitive function, mood, chronic stress, prospects microbiota-gut-brain axis for dementia. Although animal models revealed promising approaches treating microbiota, it may premature incorporate these interventions into standard clinical practice. The heterogeneity findings trials randomized control yet convincingly demonstrate efficacy reversing complications.
Language: Английский
Citations
0
Archives of Internal Medicine Research, Journal Year: 2024, Volume and Issue: 07(02)
Published: Jan. 1, 2024
The review delves into the methods for quantitative assessment of intracellular effectors and cellular response Receptor Advanced Glycation End products (RAGE), a vital transmembrane receptor involved in range physiological pathological processes. RAGE bind to (AGEs) other ligands, which turn activate diverse downstream signaling pathways that impact responses such as inflammation, oxidative stress, immune reactions. article discusses activated by followed differential activation across various diseases. This will ultimately guide researchers developing targeted effective interventions diseases associated with activation. Further, we have discussed how PCR, western blotting, microscopic examination molecules can be leveraged monitor, diagnose, explore involving proteins unique post-translational modifications. underscores pressing need advancements molecular approaches disease detection management RAGE.
Language: Английский
Citations
3
Journal of Applied Gerontology, Journal Year: 2024, Volume and Issue: 43(10), P. 1449 - 1460
Published: April 23, 2024
This study explored the association between diabetes, cognitive imFpairment (CI), and mortality in a cohort of 2931 individuals aged 60 above from 2011 to 2014 NHANES. Mortality data was gathered through 2019, multivariable Cox proportional hazards models were used determine CI, adjusting for sociodemographic characteristics, lifestyle factors, comorbidity conditions. The spanned up 9.17 years, observing 579 deaths, with having both diabetes CI showing highest all-cause (23.6 events per 100 patient-years). Adjusted analysis revealed 2.34-fold higher risk this group, surpassing those or alone. These results held after series stratified sensitivity analyses. In conclusion, linked emphasizing need address dysfunction diabetic patients.
Language: Английский
Citations
2
Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 353, P. 128660 - 128660
Published: July 3, 2024
Language: Английский
Citations
1
Enfermedades infecciosas y microbiologia clinica (English ed ), Journal Year: 2024, Volume and Issue: 42(2), P. 118 - 119
Published: Feb. 1, 2024
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: April 10, 2024
To determine the experiences and needs of palliative care in patients with advanced Parkinson's disease (PD).
Language: Английский
Citations
0
PubMed, Journal Year: 2024, Volume and Issue: 44(5), P. 876 - 884
Published: May 20, 2024
To investigate the mechanisms that mediate neuroprotective effect of intestinal microbial metabolite sodium butyrate (NaB) in a mouse model Parkinson's disease (PD)
Language: Английский
Citations
0