Exploring the Larvicidal and Repellent Potential of Taurus Cedar (Cedrus libani) Tar against the Brown Dog Tick (Rhipicephalus sanguineus sensu lato)

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7689 - 7689

Published: Nov. 21, 2023

This study investigated the potential acaricidal and repellent effects of tar obtained from Lebanon cedar (Cedrus libani A. Rich.) against brown dog tick species Rhipicephalus sanguineus sensu lato Latreille (Acari: Ixodidae). The goal was to find an alternative, safe, effective way eliminate ticks. Tar is traditionally extracted trees in Antalya region Türkiye. composition primarily characterized by a diverse mixture terpenes, with β-himachalene (29.16%), α-atlantone (28.7%), ar-turmerone (8.82%), longifolene-(V4) (6.66%), α-himachalene (5.28%), β-turmerone (5.12%) emerging as predominant constituents. toxic on larvae were studied through larval immersion tests (LIT), its activity evaluated using new test (LRAT). results revealed significant effects, mortality rates 77.7% 82.2% for Konyaalti Kepez strains tick, respectively, response 1% concentration tar. LC50 LC90 values determined 0.47% 1.52% strain 0.58% 1.63% strain, respectively. When comparing effect widely used synthetic DEET, repellency up 100% observed. As result, this establishes, first time, larvicidal C.

Language: Английский

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Neem Leaf Extract Exhibits Anti-Aging and Antioxidant Effects from Yeast to Human Cells

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1506 - 1506

Published: May 16, 2024

Neem leaves have long been used in traditional medicine for promoting longevity. However, the precise mechanisms underlying their anti-aging effects remain elusive. In this study, we investigated impact of neem leaf extract (NLE) extracted from a 50% ethanol solution on chronological lifespan Saccharomyces cerevisiae, revealing an extension lifespan, heightened oxidative stress resistance, and reduction reactive oxygen species. To discern active compounds NLE, LC/MS GNPS platform were employed. The majority identified found to be flavonoids. Subsequently, compound-target pharmacological networks constructed using STP STITCH platforms both S. cerevisiae Homo sapiens. GOMF KEGG enrichment analyses predicted targets revealed that “oxidoreductase activity” was among top enriched terms yeast human cells. These suggested potential regulation response (OSR) by NLE. RNA-seq analysis NLE-treated corroborated anti-oxidative effect, with “oxidation-reduction process” ranking high GO terms. Notably, CTT1, encoding catalase, emerged as most significantly up-regulated gene within cluster. ctt1 null mutant, enhanced resistance extended induced NLE nullified. For cells, pretreatment demonstrated decrease species levels senescence-associated β-galactosidase activity HeLa indicative effects. This study unveils properties while delving into mechanisms, providing novel insights interventions aging phytochemicals.

Language: Английский

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Prenatal exposure of azadiradione leads to developmental disabilities

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Azadiradione is a brain permeable phytochemical present in the seed of an Indian medicinal plant, Azadirachta Indica, well-known as Neem. Recently, this small bioactive molecule has been revealed to induce expression Ube3a, ubiquitin ligase whose loss and gain function associated with two diverse neurodevelopmental disorders. Here we report that in uteroexposure azadiradione mice result severe developmental disabilities. Treatment well tolerated dose into pregnant dam (at embryonic day 12 14) causes substantial decrease body weight new-born pups at their early periods along significant cognitive, motor communication deficits increased anxiety-like behaviours. As animals grow from adolescent adult, many behavioural are gradually restored normalcy, although, cognitive deficit persists significantly. Biochemical analysis reveals prenatally exposed exhibits about 2-3 fold increase level Ube3a post natal 25 some its target proteins linked synaptic plasticity indicating enduring effect drug on expression. The also display number dendritic spines hippocampal cortical pyramidal neurons. These results suggest might be one key players azadiradione-induced

Language: Английский

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Prenatal Exposure to Azadiradione Leads to Developmental Disabilities

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

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Critical role of neem and jujube extracts in stabilizing copper nanostructures: A comparative study in green synthesis of CuNSs

Current Research in Green and Sustainable Chemistry, Journal Year: 2024, Volume and Issue: 9, P. 100437 - 100437

Published: Jan. 1, 2024

Language: Английский

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Azadirachta indica L.

Medicinal and aromatic plants of the world, Journal Year: 2024, Volume and Issue: unknown, P. 47 - 59

Published: Jan. 1, 2024

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