Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Bone
homeostasis
encompasses
two
interrelated
aspects:
bone
remodeling
and
cartilage
metabolism.
Disruption
of
can
lead
to
the
development
metabolic
diseases
such
as
osteoporosis
osteoarthritis.
The
maintenance
is
a
complex
process
that
does
not
solely
rely
on
functions
tissue
itself.
In
fact,
an
isolated
entity;
it
closely
connected
other
tissues
in
body
via
exosomes.
Within
this
interconnectivity,
exosomes
derived
from
both
non-bone
cells
interfere
with
each
other,
forming
regulatory
network.
Therefore,
cell
origin
guiding
principle,
we
have
delineated
network
exosomes,
elaborated
specific
roles
mechanisms
common
types
(cells
within
skeletal
microenvironment,
stem
extra-osseous
tissues,
vascular-derived
cells,
muscle-derived
neurogenic
cells)
formation,
resorption,
We
also
discussed
challenges
faced
field
exosome
research
related
homeostasis,
unveiled
critical
role
maintaining
proposed
could
serve
highly
valuable
therapeutic
targets
for
diseases.
Journal of Dental Sciences,
Journal Year:
2024,
Volume and Issue:
20(1), P. 539 - 552
Published: May 4, 2024
Bisphosphonate-related
osteonecrosis
of
the
jaw
(BRONJ),
a
complication
arising
from
use
bisphosphonates
(BPs),
inflicts
long-term
suffering
on
patients.
Currently,
there
is
still
lack
effective
treatments.
This
study
aimed
to
explore
preventive
effects
propranolol
(PRO)
BRONJ
in
vitro
and
vivo,
given
PRO's
potential
bone
health
enhancement.
In
vitro,
effect
PRO
zoledronic
acid
(ZA)-pretreated
marrow
mesenchymal
stem
cells
(BMSCs)
was
detected
by
cell
counting
kit-8,
alkaline
phosphatase
(ALP)
staining,
alizarin
red
real-time
quantitative
polymerase
chain
reaction
(RT-qPCR)
Western
blot.
forty
mice
were
divided
into
four
groups:
control,
ZA,
PRO,
ZA-PRO.
The
maxillary
extraction
sockets
sides
analyzed
with
micro-CT
histomorphometry.
Hematoxylin-eosin
(H&E),
Masson
immunofluorescence
staining
ALP,
morphogenetic
protein
2
(BMP2),
runt-related
transcription
factor
(RUNX2)
TUNEL
performed.
increased
proliferation
osteogenic
differentiation
BMSCs.
stimulated
formation
facilitated
healing
process
acid-induced
mouse
model.
Compared
ZA
group,
control
group
showed
more
BMP2+,
RUNX2+,
ALP+
(P
<
0.05).
However,
rescued
decreased
expression
RUNX2,
BMP2
due
findings
suggest
that
may
offer
promising
strategy
against
enhancing
regeneration.
research
contributes
understanding
pathogenesis
opens
avenues
for
treatments
focusing
β-adrenergic
signaling.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 21, 2024
Abstract
Impaired
callus
remodeling
significantly
contributes
to
the
delayed
healing
of
osteoporotic
fractures;
however,
underlying
mechanisms
remain
unclear.
Sensory
neuronal
signaling
plays
a
crucial
role
in
bone
repair.
In
this
study,
we
demonstrate
that
ovariectomized
(OVX)
mice,
loss
CGRP
+
TrkA
sensory
during
correlates
with
increased
Cx3cr1
iOCs
expression
within
callus.
Conditional
knockout
restored
neuronal,
enabling
normal
progression.
Mechanistically,
further
secrete
seme3A
fracture
repair
microenvironment,
inhibiting
neurons’
axonal
regeneration
and
suppressing
nerve-bone
exchange,
thus
hindering
remodeling.
Lastly,
human
samples,
observed
an
association
between
iOCs.
conclusion,
enhancing
nerve
by
activity
presents
potential
strategy
for
treating
fractures.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 20, 2024
While
prior
research
has
established
a
correlation
between
dietary
choline
intake
and
bone
density
in
the
elderly,
relationship
adolescents
remains
ambiguous.
This
study
seeks
to
examine
association
American
adolescents.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Bone
homeostasis
encompasses
two
interrelated
aspects:
bone
remodeling
and
cartilage
metabolism.
Disruption
of
can
lead
to
the
development
metabolic
diseases
such
as
osteoporosis
osteoarthritis.
The
maintenance
is
a
complex
process
that
does
not
solely
rely
on
functions
tissue
itself.
In
fact,
an
isolated
entity;
it
closely
connected
other
tissues
in
body
via
exosomes.
Within
this
interconnectivity,
exosomes
derived
from
both
non-bone
cells
interfere
with
each
other,
forming
regulatory
network.
Therefore,
cell
origin
guiding
principle,
we
have
delineated
network
exosomes,
elaborated
specific
roles
mechanisms
common
types
(cells
within
skeletal
microenvironment,
stem
extra-osseous
tissues,
vascular-derived
cells,
muscle-derived
neurogenic
cells)
formation,
resorption,
We
also
discussed
challenges
faced
field
exosome
research
related
homeostasis,
unveiled
critical
role
maintaining
proposed
could
serve
highly
valuable
therapeutic
targets
for
diseases.
