ChemBioChem,
Journal Year:
2023,
Volume and Issue:
24(17)
Published: July 4, 2023
Synthetic
light-driven
consortia
composed
of
phototrophs
and
heterotrophs
have
attracted
increasing
attention
owing
to
their
potential
be
used
in
sustainable
biotechnology.
In
recent
years,
synthetic
phototrophic
been
produce
bulk
chemicals,
biofuels,
other
valuable
bioproducts.
addition,
autotrophic-heterotrophic
symbiosis
systems
applications
wastewater
treatment,
bioremediation,
as
a
method
for
phytoplankton
bloom
control.
Here,
we
discuss
progress
made
on
the
biosynthesis
microbial
consortia.
strategies
optimizing
are
summarized.
Moreover,
highlight
current
challenges
future
research
directions
development
robust
controllable
Journal of Industrial Microbiology & Biotechnology,
Journal Year:
2024,
Volume and Issue:
51
Published: Jan. 1, 2024
Abstract
Growing
environmental
concerns
and
the
need
to
adopt
a
circular
economy
have
highlighted
importance
of
waste
valorization
for
resource
recovery.
Microbial
consortia-enabled
biotechnologies
made
significant
developments
in
biomanufacturing
valuable
resources
from
biomass
that
serve
as
suitable
alternatives
petrochemical-derived
products.
These
microbial
consortia-based
processes
are
designed
following
top-down
or
bottom-up
engineering
approach.
The
approach
is
classical
method
uses
variables
selectively
steer
an
existing
consortium
achieve
target
function.
While
high-throughput
sequencing
has
enabled
community
characterization,
major
challenge
disentangle
complex
interactions
manipulate
structure
function
accordingly.
prior
knowledge
metabolic
pathway
possible
among
partners
design
engineer
synthetic
consortia.
This
strategy
offers
some
control
over
composition
targeted
bioprocesses,
but
challenges
remain
optimal
assembly
methods
long-term
stability.
In
this
review,
we
present
recent
advancements,
challenges,
opportunities
further
improvement
using
approaches
microbiome
engineering.
As
relatively
new
concept
valorization,
review
explores
consortia,
ecological
principles
optimize
efficient
conversion.
Integration
along
with
modeling
predict
consortia
also
highlighted.
One-Sentence
Summary
highlights
consortia-driven
through
describes
strategies,
tools,
unexplored
stability
such
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: April 28, 2023
Abstract
In
microbial
systems,
a
metabolic
pathway
can
be
either
completed
by
one
autonomous
population
or
alternatively
distributed
among
consortium
performing
division
of
labor
(MDOL),
where
several
specialized
populations
cooperate
to
complete
the
pathway.
MDOL
facilitates
system’s
function
reducing
burden;
however,
it
may
also
hinder
exchange
efficiency
intermediates
individuals.
As
result,
community
is
influenced
trade-offs
between
specialization
and
versatility
individuals,
with
latter
potentially
introducing
redundancy
into
community.
However,
remains
unclear
how
individuals
involved
controlled
in
order
optimize
this
study,
we
deconstructed
naphthalene
degradation
four
steps
introduced
them
individually
combinatorically
different
strains,
varying
levels
specialization.
Using
these
engineered
1,456
synthetic
consortia
tested
their
efficiency.
We
found
that
74
possessing
exhibited
higher
than
both
rigorous
Quantitative
modeling
derived
from
our
experiments
provides
general
strategies
for
identifying
most
effective
functional
(MCFR)
range
possible
MCFRs.
Our
large-scale
genomic
analysis
suggests
natural
communities
hydrocarbon
are
mostly
functionally
redundant.
summary,
study
critical
insights
engineering
high-performance
systems
explains
why
prevalent
communities.
ChemBioChem,
Journal Year:
2023,
Volume and Issue:
24(17)
Published: July 4, 2023
Synthetic
light-driven
consortia
composed
of
phototrophs
and
heterotrophs
have
attracted
increasing
attention
owing
to
their
potential
be
used
in
sustainable
biotechnology.
In
recent
years,
synthetic
phototrophic
been
produce
bulk
chemicals,
biofuels,
other
valuable
bioproducts.
addition,
autotrophic-heterotrophic
symbiosis
systems
applications
wastewater
treatment,
bioremediation,
as
a
method
for
phytoplankton
bloom
control.
Here,
we
discuss
progress
made
on
the
biosynthesis
microbial
consortia.
strategies
optimizing
are
summarized.
Moreover,
highlight
current
challenges
future
research
directions
development
robust
controllable
