Food Chemistry Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
6, P. 100155 - 100155
Published: Dec. 13, 2022
Chronic
Non-Communicable
Diseases
(NCDs)
have
been
considered
a
global
health
problem,
characterized
as
diseases
of
multiple
factors,
which
are
developed
throughout
life,
and
regardless
genetics
risk
factor
important
relevance,
the
increase
in
mortality
attributed
to
disease
environmental
factors
lifestyle
one
leads.
Although
reactive
species
(ROS/RNS)
necessary
for
several
physiological
processes,
their
overproduction
is
directly
related
pathogenesis
aggravation
NCDs.
In
contrast,
dietary
polyphenols
widely
associated
with
minimizing
oxidative
stress
inflammation.
addition
antioxidant
power,
also
drawn
attention
being
able
modulate
both
gene
expression
modify
epigenetic
alterations,
suggesting
an
essential
involvement
prevention
and/or
development
some
pathologies.
Therefore,
this
review
briefly
explained
mechanisms
NCDs,
followed
by
summary
evidence
interaction
stress,
well
modulation
involved
management
Some
polyphenol-derived
metabolites
reach
human
breast
cancer
(BC)
tissues
at
concentrations
that
induce
cell
senescence.
However,
this
is
unknown
for
isoflavones,
curcuminoids,
and
lignans.
Here,
their
metabolic
profiling
in
normal
(NT)
malignant
(MT)
mammary
of
newly-diagnosed
BC
patients
the
tissue-occurring
metabolites'
anticancer
activity
are
evaluated.Patients
(n
=
26)
consumed
3
capsules/day
(turmeric,
red
clover,
flaxseed
extracts
plus
resveratrol;
296.4
mg
phenolics/capsule)
from
biopsy-confirmed
diagnosis
to
surgery
(5
±
2
days)
or
did
not
consume
capsules
13).
NT
MT,
blood,
urine
analyzed
by
UPLC-QTOF-MS
using
targeted
metabolomics.
Anticancer
was
tested
MCF-7
MDA-MB-231
cells.
Mainly
phase-II
were
detected
(108,
84,
49,
47
urine,
plasma,
NT,
respectively).
Total
metabolite
reached
10.7
11.1
2.5
2.4
µmol
L-1
respectively.
Free
curcumin,
but
its
glucuronide,
(1.1
1.8
0.2
Breast
antiproliferation
mainly
exerted
p53-wild-type
cells
curcuminoids
through
cycle
arrest,
senescence,
apoptosis
induction
via
p53/p21
induction,
while
isoflavone-derived
estrogenic-like
activity.Curcuminoids
could
be
coadjuvants
might
help
fight
upon
regular
consumption.
Molecular Aspects of Medicine,
Journal Year:
2022,
Volume and Issue:
89, P. 101109 - 101109
Published: Aug. 5, 2022
Ellagitannins
(ETs)
and
ellagic
acid
(EA)
are
dietary
polyphenols
poorly
absorbed
but
extensively
metabolized
by
the
human
gut
microbiota
to
produce
different
urolithins
(Uros).
Depending
on
individuals'
microbial
signatures,
ETs
metabolism
can
yield
Uro
metabotypes
A,
B,
or
0,
potentially
impacting
health
after
consuming
ETs.
Human
evidence
points
improved
brain
ET-rich
foods,
mainly
pomegranate
juices
extracts
containing
punicalagin,
punicalin,
EA-derivatives.
Although
(or)
EA
necessary
exert
effects,
precise
mechanism,
actual
metabolites,
final
drivers
responsible
for
observed
effects
have
not
been
unraveled.
The
cause-and-effect
Uro-A
administration
improvement
of
animal
is
consistent
addressed
in
humans.
Uro-A's
vivo
anti-inflammatory,
mitophagy,
autophagy,
mitochondrial
biogenesis
activities
suggest
it
as
a
possible
driver
neuroprotection.
However,
metabolic
forms
reaching
unknown.
In
addition
participation
direct
effectors
tissues,
current
out
that
improving
blood
flow,
ecology,
barrier
foods
could
contribute
neuroprotective
effects.
We
show
here
health,
link
between
their
including
preservation
integrity,
role
Uros.
Finally,
we
propose
roadmap
address
what
missing
ETs,
Uros,
Food Chemistry Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
6, P. 100155 - 100155
Published: Dec. 13, 2022
Chronic
Non-Communicable
Diseases
(NCDs)
have
been
considered
a
global
health
problem,
characterized
as
diseases
of
multiple
factors,
which
are
developed
throughout
life,
and
regardless
genetics
risk
factor
important
relevance,
the
increase
in
mortality
attributed
to
disease
environmental
factors
lifestyle
one
leads.
Although
reactive
species
(ROS/RNS)
necessary
for
several
physiological
processes,
their
overproduction
is
directly
related
pathogenesis
aggravation
NCDs.
In
contrast,
dietary
polyphenols
widely
associated
with
minimizing
oxidative
stress
inflammation.
addition
antioxidant
power,
also
drawn
attention
being
able
modulate
both
gene
expression
modify
epigenetic
alterations,
suggesting
an
essential
involvement
prevention
and/or
development
some
pathologies.
Therefore,
this
review
briefly
explained
mechanisms
NCDs,
followed
by
summary
evidence
interaction
stress,
well
modulation
involved
management
