Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147

Published: March 1, 2024

Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.

Language: Английский

---

The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1017 - 1017

Published: Aug. 16, 2024

Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.

Language: Английский

---

Characterization of Langra Mango Peel Powder and Assessment of Its Prebiotic and Antioxidant Potential

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 17

Published: March 21, 2024

The possibility of developing waste by-products food processing into functional additives along with probiotics is an interesting avenue to research. This study investigated the nutritional and attributes dried mango peel powder (MPP) Langra cultivar its putative potential act as a prebiotic in presence two probiotic strains Lacticaseibacillus rhamnosus NCDC347 Limosilactobacillus fermentum NCDC143 @ 2.5 & 5% after 24 48 h fermentation. Proximate analysis revealed that MPP contains 6.45 % moisture, 6.34 protein, 3.88 fat, 2.50 ash, 32.86 crude dietary fiber, 47.97 total carbohydrate content. MP displayed substantial antioxidant 54.6% DPPH inhibitory activity, 15.67 mg GAE/g TPC, 8.88 QuE/g TFC, OHC 1.47 g oil/g, WHC 4.7 water/g. could selectively stimulate growth over enteric bacteria. It was combination @5% L. fermentation had best vitro activity score 3.35 3.53 against Escherichia coli ATCC 25922 Enterococcus faecalis NCDC114, respectively. better than commercial malto-dextrin for all combinations tested. percentage inhibition increased during NCDC143, highlighting role source antioxidants. These findings contribute formulation synbiotic products are able maintain selected healthy microbiota human gut.

Language: Английский

---

Exploring the probiotic and prebiotic dynamics of cheese: An updated review

Annals of Phytomedicine An International Journal, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 1, 2024

In recent years, the inoculation of different probiotic cultures along with suitable prebiotics into various fermented dairy products has significantly increased in popularity within food industry.Consumers, who value distinct tastes and characteristics regional flavors, have been driving force behind this trend.The growing interest stems from a shared desire to improve human nutrition, promote better health, enhance sensory experience products.Probiotic microorganisms present cheese confer numerous benefits, including protection against harmful gut pathogens, alleviation specific types diarrhea, reduction high-risk infant discomfort, while act as essential nourishment for probiotics, facilitating their growth activity gastrointestinal tract.The synergistic effects probiotics are pivotal modulating microbiota composition, enhancing immune function, improving nutrient absorption, mitigating disorders, underscoring combined role promoting health overall well-being.Understanding harnessing symbiotic relationship crucial developing innovative that cater consumer preferences provide tangible benefits.This review focuses on selection, addition, functionality aspects cheese, which contribute creating wholesome functional product.

Language: Английский

---

ClpL Chaperone as a Possible Component of the Disaggregase Activity of Limosilactobacillus fermentum U-21

Published: May 27, 2024

Strain L. fermentum U-21 secretes chaperones into the medium and it is considered as candidate for development of drugs, so-called disaggregases, Parkinson’s disease therapy. This study devoted to characterization secreted protein encoded by C0965_000195 locus. Analysis sequence predicted structure allows us attribute ClpL, homologs which are known be chaperones. The chaperone activity ClpL was evaluated in vivo refolding differing thermostability luciferases from Aliivibrio fischeri Photorhabdus luminescens Escherichia coli cells. It observed that clpL can compensate deficiency clpB gene enhance ability refold thermodenatured proteins clpB- In vitro experiments have demonstrated a spent culture containing cells, including prevent thermodenaturation partially.We suggest strain, exhibits disaggregase properties against aggregating proteins, may one clue components play role pharmabiotic this strain.

Language: Английский

---

Gut dysbiosis mediates the association between antibiotic exposure and chronic disease

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

Antibiotics are safe, effective drugs and continue to save millions of lives prevent long-term illness worldwide. A large body epidemiological, interventional experimental evidence shows that exposure antibiotics has negative effects on human health. We reviewed the literature data links between antibiotic exposure, gut dysbiosis, chronic disease (notably with regard “developmental origins health disease” (“DOHaD”) approach). Molecular biology studies show systemic administration infants a rapid onset but also often long-lasting impact microbial composition gut. Along other environmental factors (e.g., an unhealthy “Western” diet sedentary behavior), induce which can be defined as disruption previously stable, functionally complete microbiota. Gut dysbiosis many harmful Associations early-life have been reported for diseases, including inflammatory bowel disease, celiac some cancers, metabolic diseases (obesity type 2 diabetes), allergic autoimmune disorders, atherosclerosis, arthritis, neurodevelopmental, neurodegenerative neurological diseases. In mechanistic terms, influences through direct mucosal immune pathways, plus wide array or indirect short-chain fatty acids, enteric nervous system, peristaltic motility, production hormones neurotransmitters, loss intestinal barrier integrity leakage pro-inflammatory endotoxin lipopolysaccharide into circulation). To mitigate probiotics in patients is (but not always) associated positive clinical markers scores) biomarkers inflammation activation. Meta-analyses complicated by differences probiotic composition, dose level, treatment duration, large, randomized, controlled trials lacking areas. view critical importance deciding whether prescribe (especially children), we suggest DOHaD concept logically extended “gastrointestinal (“GOHaD”) even “microbiotic (“MOHaD”).

Language: Английский

---

Resolving a paradox: antidepressants, neuroinflammation, and neurodegeneration

Exploration of Neuroprotective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 11 - 37

Published: Feb. 23, 2024

Depression is a known risk factor for dementia. Antidepressants are the most commonly used treatment this condition, and effective in at least half to two-thirds of cases. Extensive evidence from vitro animal models suggests that antidepressants have anti-inflammatory neuroprotective properties. These effects been shown reduce oxidative damage, amyloid aggregation, expression pro-inflammatory genes associated with neurodegenerative disorders. However, longitudinal research humans has do not protect against dementia, may even be cognitive deterioration over time older adults. The contrast between two sets findings represents paradox significant clinical public health significance, particularly when treating depression late life. This review paper attempts resolve by critically reviewing medium- long-term on peripheral immune-inflammatory responses, infection risk, gut microbiota, neuroendocrine responses stress, how these influence neurodegeneration. Briefly stated, it possible actions antidepressant medications antagonize their beneficial neuroinflammation. implications then explored particular focus development testing multimodal treatments could Alzheimer’s related dementias patients suffering depression.

Language: Английский

---

ClpL Chaperone as a Possible Component of the Disaggregase Activity of Limosilactobacillus fermentum U-21

Biology, Journal Year: 2024, Volume and Issue: 13(8), P. 592 - 592

Published: Aug. 6, 2024

The

Language: Английский

---

Selection of GABA-Producing Lactic Acid Bacteria Strains by Polymerase Chain Reaction Using Novel gadB and gadC Multispecies Primers for the Development of New Functional Foods

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13696 - 13696

Published: Dec. 21, 2024

Gamma-aminobutyric acid (GABA) has been attributed to health-promoting properties and received attention from the food industry as an attractive bioactive compound for development of functional foods. Some lactic bacteria (LAB) produce GABA through a glutamate decarboxylase encoded by gadB glutamate/GABA antiporter gadC. In this study, we develop molecular screening method based on polymerase chain reaction able detect those genes in different LAB species use novel multispecies primers. PCR was performed 92 strains six species. The primer pair designed allowed its identification Lactiplantibacillus plantarum, Lactococcus cremoris, lactis, Levilactobacillus brevis, Limosilactobacillus fermentum, reuteri strains. For gadC, two pairs were detection Glutamate activity (GAD assay) GABase enzymatic quantification also assessed. Among showing activity, 93.2% harbored gene, production had gene exhibited activity. correlates strongly with constitutes good strategy selection high yields (>18 mM) that could be used GABA-enriched

Language: Английский

---

Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Aging often accompanies cognitive and mood disturbances. Emerging evidence indicates that specific probiotics mitigate dysfunctions. Strains within

Language: Английский

---