Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity DOI Creative Commons
Sha Lei, Guanghui Liu, Shouli Wang

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(22)

Published: Nov. 1, 2024

Scope Adipose tissue macrophages (ATMs) are crucial in the pathogenesis of insulin resistance (IR). Intermittent fasting (IF) is an effective intervention for obesity. However, underlying mechanism by which IF improves IR remains unclear. Methods and results Male C57BL/6J mice fed chow‐diet high‐fat diet (HFD) 12 weeks, then randomized into ad libitum feeding or every other day 8 weeks. Markers ATMs expression uncoupling protein 1 (UCP‐1) determined. Gut microbiota bile acids (BAs) profiled using 16S rRNA sequencing targeted metabolomics analysis. Results indicate that HFD‐induced decreases ATM infiltration, pro‐inflammatory M1 gene expression, promotes white adipose (WAT) browning elevating UCP‐1 expression. restructures composition, significantly expanding abundance Verrucomicrobia particularly Akkermansia muciniphila , with decrease Firmicutes . increases level total BAs alters composition higher proportion 12α‐hydroxylated (12α‐OH) BAs. The changes these correlated differential bacteria. Conclusion findings partially mediated interplay between restructured gut metabolism, has implications dietary management

Language: Английский

Persimmon (Diospyros kaki Thunb.) Leaf Polyphenols: Impact on Digestive Degradation and Human Gut Microbiota Regulation DOI
Jing Liu, Jialin Qu, Ying Gao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106251 - 106251

Published: Feb. 1, 2025

Language: Английский

Citations

0
Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity DOI Creative Commons
Sha Lei, Guanghui Liu, Shouli Wang

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(22)

Published: Nov. 1, 2024

Scope Adipose tissue macrophages (ATMs) are crucial in the pathogenesis of insulin resistance (IR). Intermittent fasting (IF) is an effective intervention for obesity. However, underlying mechanism by which IF improves IR remains unclear. Methods and results Male C57BL/6J mice fed chow‐diet high‐fat diet (HFD) 12 weeks, then randomized into ad libitum feeding or every other day 8 weeks. Markers ATMs expression uncoupling protein 1 (UCP‐1) determined. Gut microbiota bile acids (BAs) profiled using 16S rRNA sequencing targeted metabolomics analysis. Results indicate that HFD‐induced decreases ATM infiltration, pro‐inflammatory M1 gene expression, promotes white adipose (WAT) browning elevating UCP‐1 expression. restructures composition, significantly expanding abundance Verrucomicrobia particularly Akkermansia muciniphila , with decrease Firmicutes . increases level total BAs alters composition higher proportion 12α‐hydroxylated (12α‐OH) BAs. The changes these correlated differential bacteria. Conclusion findings partially mediated interplay between restructured gut metabolism, has implications dietary management

Language: Английский

Citations

2