Journal of Medical Physics,
Journal Year:
2024,
Volume and Issue:
49(4), P. 583 - 596
Published: Oct. 1, 2024
Focused
ultrasound
(FUS)
therapies
are
often
performed
within
magnetic
resonance
imaging
(MRI)
systems
providing
thermometry-based
temperature
monitoring.
Herein,
MRI
thermometry
was
assessed
for
FUS
sonications
executed
using
a
preclinical
system
on
agar-based
phantoms
at
1.5T
and
3T
scanners,
the
proton
frequency
shift
technique.
Sonications
were
to
assess
observe
variations
in
(MR)
measurements.
MR
3T,
identical
three
doped
with
varied
silica
evaporated
milk
concentrations,
acoustic
power
of
1.5-45
W.
Moreover,
echo
time
(TE)
values
5-20
ms
used
effect
signal-to-noise
ratio
(SNR)
change
sensitivity.
Clearer
thermal
maps
2.5-fold
higher
temporal
resolution
produced
compared
1.5T,
despite
employment
similar
sequences.
At
changes
between
41°C
50°C
recorded
milk,
addition
2%
w/v
resulting
20%
increase
change.
The
lowest
that
reliable
beam
detection
voxel
1.5
A
TE
10
resulted
highest
sensitivity
adequate
SNR.
achieved
short
dependencies
exhibited
sonication
parameters.
Present
data
could
be
MRI-guided
feasibility
studies
enhance
thermometry.
Magnetic Resonance Materials in Physics Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
37(4), P. 535 - 549
Published: June 19, 2024
In
this
paper,
we
review
the
value
of
phantoms
for
body
MRI
in
context
their
uses
quantitative
methods
research,
clinical
trials,
and
imaging.
Certain
are
common
throughout
community,
including
measuring
bias,
assessing
reproducibility,
training.
addition
to
these
uses,
research
used
novel
development
design
motion
compensation
mitigation
techniques.
For
an
essential
part
quality
management
strategies,
facilitating
conduct
ethically
sound,
reliable,
regulatorily
compliant
both
therapeutic
agents.
clinic,
protocols,
cost,
control,
radiotherapy.
We
briefly
developed
MRI,
finally,
open
questions
regarding
most
effective
use
a
phantom
MRI.
Skeletal Radiology,
Journal Year:
2024,
Volume and Issue:
53(9), P. 1869 - 1877
Published: Feb. 16, 2024
Abstract
Magnetic
resonance-guided
focused
ultrasound
(MRgFUS)
is
a
noninvasive,
incisionless,
radiation-free
technology
used
to
ablate
tissue
deep
within
the
body.
This
technique
has
gained
increased
popularity
following
FDA
approval
for
treatment
of
pain
related
bone
metastases
and
limited
osteoid
osteoma.
MRgFUS
delivers
superior
visualization
soft
targets
in
unlimited
imaging
planes
precision
targeting
delivery
thermal
dose
which
all
provided
during
real-time
monitoring
using
MR
thermometry.
paper
provides
an
overview
common
musculoskeletal
applications
along
with
updates
on
clinical
outcomes
discussion
future
applications.
Acta Neurochirurgica,
Journal Year:
2025,
Volume and Issue:
167(1)
Published: Jan. 14, 2025
Abstract
Background
Intraoperative
ultrasound
is
becoming
a
common
tool
in
neurosurgery.
However,
effective
simulation
methods
are
limited.
Current,
commercial,
and
homemade
phantoms
lack
replication
of
anatomical
correctness
texture
complexity
brain
tumour
tissue
images.
Methods
We
utilise
ex-vivo
tissue,
as
opposed
to
synthetic
materials,
achieve
realistic
echogenic
correctness.
Agar,
at
10–20%
concentrate,
injected
into
simulate
the
mass.
A
commercially
available
phantom
was
purchased
for
benchmarking.
Results
Qualitative
analysis
performed
by
experienced
professionals,
measuring
impact
addition
agar
comparing
it
commercial
phantom.
Overall,
use
ex
vivo
deemed
more
accurate
representative,
compared
materials-based
phantom,
provided
good
visualisation
real
anatomy
contrast
within
tissue.
The
correctly
produced
region
higher
echogenicity
with
slight
diffusion
along
margin
expected
interaction
neighbouring
anatomy.
Conclusion
proposed
method
creating
tumour-mimicking
inexpensive,
accurate,
simple.
Beneficial
both
trainee
clinician
researcher.
total
576
annotated
images
made
publicly
upon
request.
Journal of Medical Physics,
Journal Year:
2025,
Volume and Issue:
50(1), P. 38 - 45
Published: Jan. 1, 2025
This
study
presents
the
outcomes
of
a
series
magnetic
resonance
imaging
(MRI)-guided
focused
ultrasound
(MRgFUS)
sonications
performed
on
an
anatomically
accurate
head
phantom
with
embedded
tumor
simulator
to
evaluate
effectiveness
partial
and
complete
ablation
obstruction
from
thin
polymer
skull
mimics.
The
was
subjected
single
grid
using
single-element
concave
transducer
integrated
MRI-compatible
(FUS)
robotic
system.
All
experiments
were
carried
out
in
high-field
MRI
scanner
utilizing
proton
frequency
thermometry
T2-weighted
(T2-W)
turbo
spin
echo
(TSE)
induced
thermal
effects.
FUS
transmission
through
1-mm
thick
three-dimensional-printed
mimics
compared
unobstructed
sonication
circular
aperture
model.
T2-W
TSE
demonstrated
sharp
contrast
between
hyperintense
lesions.
Complete
coverage
achieved
robotic-assisted
without
mimic,
as
well
resin
mimic
intervening
beam.
With
lowest
attenuation
among
tested
polymers,
resulted
approximately
20%
reduction
focal
temperature
change
sonication,
yet
still
facilitated
beam
focusing,
raising
ablative
levels.
provides
preliminary
evidence
for
potential
application
biocompatible
implant
temporarily
replace
portion
facilitating
MRgFUS
inoperable
tumors
transducer.
tumor-embedded
proven
effective
testing
oncological
protocols
equipment.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(10), P. 5275 - 5275
Published: May 9, 2025
Breast
cancer
remains
one
of
the
leading
causes
death
among
women
globally.
Early
detection
is
critical
for
improving
patient
outcomes,
making
development
accurate
and
efficient
methods
essential
facilitating
timely
treatment
enhancing
patients’
quality
life.
Lesion
sites
are
often
associated
with
localized
temperature
increases,
which
can
be
identified
by
characterizing
thermal
gradients
using
thermometry
tools.
Ultrasound-based
techniques
preferred
obtaining
patterns
due
to
their
noninvasive,
non-ionizing
nature
cost-effectiveness
compared
like
magnetic
resonance
imaging.
This
study
focuses
on
developing
breast
tissue
models
varying
acoustic
properties,
specifically
speed
sound
across
temperatures
ranging
from
32
°C
36
in
increments
0.5
ultrasonic
inspection
diagnostic
applications.
These
simulate
healthy
tumorous
tissue,
including
fat,
gland,
tumor
layers.
Signal
variations
were
analyzed
cross-correlation
assess
changes
as
a
function
temperature.
The
proposed
methodology
offers
cost-effective,
rapid,
precise
approach
phantom
production,
intervals
through
analysis
acquired
signals.
Journal of Medical Ultrasound,
Journal Year:
2023,
Volume and Issue:
32(2), P. 121 - 133
Published: Oct. 27, 2023
Tissue-mimicking
phantoms
(TMPs)
have
been
used
extensively
in
clinical
and
nonclinical
settings
to
simulate
the
thermal
effects
of
focus
ultrasound
(FUS)
technology
real
tissue
or
organs.
With
recent
technological
developments
FUS
its
monitoring/guided
techniques
such
as
ultrasound-guided
magnetic
resonance-guided
(MRgFUS)
need
for
TMPs
are
more
important
than
ever
ensure
safety
patients
before
being
treated
with
a
variety
diseases
(e.g.,
cancer
neurological).
The
purpose
this
study
was
prepare
tumor-mimicking
phantom
(TUMP)
model
that
can
competently
tumor
is
surrounded
by
healthy
tissue.
Journal of Medical Physics,
Journal Year:
2024,
Volume and Issue:
49(2), P. 203 - 212
Published: April 1, 2024
Purpose:
The
current
study
provides
insights
into
the
challenges
of
safely
operating
a
magnetic
resonance
imaging
(MRI)-guided
focused
ultrasound
(MRgFUS)
robotic
system
in
high-field
MRI
scanner
terms
motion
accuracy.
Materials
and
Methods:
Grid
sonications
were
carried
out
phantoms
excised
porcine
tissue
3T
using
an
existing
MRgFUS
system.
Fast
low-angle
shot-based
thermometry
was
employed
for
intraprocedural
monitoring
thermal
distribution.
Results:
Strong
shifting
heated
spots
from
intended
points
observed
owing
to
electromagnetic
interference
(EMI)-induced
malfunctions
system’s
operation.
Increasing
slice
thickness
sequence
at
least
8
mm
proven
efficient
method
preserving
Conclusions:
These
findings
raise
awareness
about
EMI
effects
on
accuracy
devices
how
they
can
be
mitigated
by
employing
suitable
parameters.
Journal of Medical Physics,
Journal Year:
2024,
Volume and Issue:
49(2), P. 167 - 180
Published: April 1, 2024
Aim:
Agar-based
phantoms
are
popular
in
high
intensity
focused
ultrasound
(HIFU)
studies,
with
magnetic
resonance
imaging
(MRI)
preferred
for
guidance
since
it
provides
temperature
monitoring
by
proton
frequency
(PRF)
shift
(MR)
thermometry.
MR
thermometry
depends
on
several
factors,
thus,
herein,
the
PRF
coefficient
of
agar
was
estimated.
Materials
and
Methods:
Seven
were
developed
varied
(2,
4,
or
6%
w/v)
constant
(6%
silica
concentrations
6,
8%
to
assess
effect
concentration
coefficient.
Each
phantom
sonicated
using
acoustical
power
a
30
s
duration
both
laboratory
setting
inside
3T
MRI
scanner.
coefficients
estimated
through
linear
trends
between
phase
acquired
gradient
sequences
thermocouple-based
temperatures
changes.
Results:
Linear
regression
(
R
2
=
0.9707–0.9991)
demonstrated
proportional
dependency
change,
resulting
−0.00336
±
0.00029
−0.00934
0.00050
ppm/°C
various
recipes.
Weak
negative
correlations
observed
increased
agar.
With
concentrations,
correlation
strong.
For
all
phantoms,
calibrated
resulted
1.01–3.01-fold
higher
changes
compared
values
calculated
literature
Conclusions:
Phantoms
w/v
doped
0%–8%
best
resemble
tissue
should
be
HIFU
studies.
The
can
result
enhanced
evaluation
protocols.
