Seminars in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 138, P. 104 - 116
Published: April 5, 2022
Language: Английский
The Journal of Cell Biology, Journal Year: 2017, Volume and Issue: 217(1), P. 93 - 106
Published: Oct. 26, 2017
Nutrients are necessary for life, as they a crucial requirement biological processes including reproduction, somatic growth, and tissue maintenance. Therefore, signaling systems involved in detecting interpreting nutrient or energy levels—most notably, the insulin/insulin-like growth factor 1 (IGF-1) pathway, mechanistic target of rapamycin (mTOR), adenosine monophosphate-activated protein kinase (AMPK)—play important roles regulating physiological decisions to reproduce, grow, age. In this review, we discuss connections between reproductive senescence aging give an overview involvement nutrient-sensing pathways controlling both function lifespan. Although molecular mechanisms that affect these can be influenced by distinct tissue-, temporal-, pathway-specific events, progression is systemically coordinated integrated maintenance conjunction with capacity.
Language: Английский
Citations
139
Trends in Endocrinology and Metabolism, Journal Year: 2018, Volume and Issue: 29(11), P. 768 - 780
Published: Sept. 27, 2018
Language: Английский
Citations
138
Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12
Published: Sept. 20, 2021
The follicle is the functional unit of ovary, which composed three types cells: oocytes, granulosa cells, and theca cells. Ovarian development subsequent ovulation process are coordinated by highly complex interplay between endocrine, paracrine, autocrine signals, coordinate steroidogenesis gametogenesis. Follicle regulated mainly organs, hypothalamus, anterior pituitary, gonad, make up hypothalamic-pituitary-gonadal axis. Steroid hormones their receptors play pivotal roles in participate a series classical signaling pathways. In this review, we summarize compare role pathways, such as WNT, insulin, Notch, Hedgehog ovarian underlying regulatory mechanism. We have also found that these four pathways all interact with FOXO3, transcription factor widely known to be under control PI3K/AKT pathway has been implicated major regulation dormancy initial follicular activation ovary. Although some interactions FOXO3 not verified there high possibility plays core present from comprehensive perspective obtain better understanding process.
Language: Английский
Citations
102
Peptides, Journal Year: 2018, Volume and Issue: 122, P. 169923 - 169923
Published: Feb. 16, 2018
Language: Английский
Citations
98
AJP Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: unknown
Published: May 31, 2021
The brain has been traditionally thought to be insensitive insulin, primarily because insulin does not stimulate glucose uptake/metabolism in the (as it classic insulin-sensitive tissues such as muscle, liver, and fat). However, over past 20 years, research this field identified unique actions of brain. There is accumulating evidence that crosses into regulates central nervous system functions feeding, depression, cognitive behavior. In addition, acts regulate systemic hepatic production, lipolysis, lipogenesis, reproductive competence, sympathoadrenal response hypoglycemia. Decrements action (or resistance) can observed obesity, type 2 diabetes (T2DM), aging, Alzheimer's disease (AD), indicating a possible link between metabolic health. Here, we describe recent findings on pleiotropic highlight precise sites, specific neuronal population, roles for supportive astrocytic cells through which also discuss how boosting could therapeutic option people at an increased risk developing diseases AD T2DM. Overall, perspective article serves some these key scientific findings, identify unresolved issues, indicate future directions would serve improve lives with dysfunctions.
Language: Английский
Citations
86
Molecular Biology Reports, Journal Year: 2019, Volume and Issue: 46(2), P. 1611 - 1616
Published: Feb. 5, 2019
Language: Английский
Citations
76
Pharmacology Research & Perspectives, Journal Year: 2021, Volume and Issue: 9(2)
Published: Feb. 28, 2021
Abstract Therapeutic drug development is a long, expensive, and complex process that usually takes 12–15 years. In the early phases of discovery, in particular, there growing need for animal models ensure reduction both cost time. Caenorhabditis elegans has been traditionally used to address fundamental aspects key biological processes, such as apoptosis, aging, gene expression regulation. During last decade, with advent large‐scale platforms screenings, this invertebrate also emerged an essential tool pharmaceutical research industry identify novel drugs targets. review, we discuss reasons why C. positioned outstanding cost‐effective option highlighting advantages drawbacks model. Particular attention paid suitability nematode genetic pharmacological screenings. High‐throughput screenings have indeed contributed breakthrough wide variety candidate compounds involved extensive fields including neurodegeneration, pathogen infections metabolic disorders. The versatility nematode, which enables its instrumentation model human diseases, another attribute herein underscored. As illustrative examples, utility neurodegenerative diseases parasitic nematodes discovery industry. Summing up, review aims demonstrate impact on pipeline.
Language: Английский
Citations
71
Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 705 - 705
Published: April 2, 2022
Natural products are small molecules naturally produced by multiple sources such as plants, animals, fungi, bacteria and archaea. They exert both beneficial detrimental effects modulating biological targets pathways involved in oxidative stress antioxidant response. products’ or antioxidative properties usually investigated preclinical experimental models, including virtual computing simulations, cell tissue cultures, rodent nonhuman primate animal human studies. Due to the renewal of concept especially popularization alternative 3R methods for reduction, replacement refinement, many assessment experiments have been carried out new models. The model organism Caenorhabditis elegans has used medical research since Sydney Brenner revealed its genetics 1974 introduced into pharmacology toxicology past two decades. data from C. satisfactorily correlated with traditional In this review, we summarize advantages assessing natural introduce construct an damage elegans. biomarkers signaling summarized, well oxidation antioxidation target organs muscle, nervous, digestive reproductive systems. This review provides overview based on
Language: Английский
Citations
40
Trends in Ecology & Evolution, Journal Year: 2020, Volume and Issue: 35(11), P. 981 - 989
Published: July 26, 2020
Individual differences are central in behavior, ecology, and evolution, because they determine which selective factors relevant for an individual interaction with its environment; yet ecological niches have rarely been studied on level.The subset of the species' niche realized by is called individualized implemented three major processes: choice, conformance, construction.Infochemicals can differ between individuals empower realization niche. Combining hormones semiochemicals under term infochemicals highlights their common function information transfer within or organisms.We give several examples how chemical mediators, including hormones, pheromones, allelochemicals, essential across animal kingdom. Infochemicals, play a role mediating shaping interactions individuals. Due to high plasticity, predestined mediators facilitating organisms. Only recently it has become clear that understand why realize tiny Moreover, both adjustment evolutionary adaptation rapidly changing world. Here we highlight act as key signals cues through proposed construction. Ecological (see Glossary) long considered n-dimensional hypervolumes populations species [1.Hutchinson G.E. Concluding remarks.Cold Spring Harb. Symp. Quant. Biol. 1957; 22: 415-427Crossref Google Scholar], whereby dimensions environmental conditions resources defined requirements all population species. Recently recognized variation plasticity should be integrated into concept [2.Layman C.A. et al.Individual-level specialization populations: emerging areas study.Oecologia. 2015; 178: 1-4Crossref PubMed Scopus (31) Scholar]. Each realizes just population's [3.Devictor V. al.Defining measuring specialization.J. Appl. Ecol. 2010; 47: 15-25Crossref (437) same might occupy multiple local fitness optima, leading divergent selection [4.Wagner A. The Origins Of Evolutionary Innovations: A Theory Transformative Change Living Systems. Oxford University Press, 2011Crossref Thus, comprehensive concept, included. For such integration need physiological circumstances modulate resulting phenotypic [5.Smith B.R. Blumstein D.T. Fitness consequences personality: meta-analysis.Behav. 2008; 19: 448-455Crossref (871) environment results via processes, namely construction (Figures 1 2). When chooses best match phenotype, shows choice. Niche conformance occurs when adjusts phenotype given environment. process modifies according needs, also affect other [6.Clark A.D. al.Niche affects variability strength natural selection.Am. Nat. 2020; 195: 16-30Crossref (10) All processes offspring facilitate better environment, enhancing individual's fitness. successful realization, appropriate communication crucial. most ancient way use chemicals chemoreception. Such may convey individual, semiochemicals, mediate Whereas traditionally seen synonymous [7.Dicke M. Sabelis M.W. Infochemical terminology: based cost-benefit analysis rather than origin compounds.Funct. 1988; 2: 131-139Crossref propose unifying (Figure age, omnipresence, involved niches, but this link so far neglected. We suggest adjustments coded realization. Integrating these will allow deeper understanding when, how, phenotypes adaptively modulated meet needs. Here, focus Our conceptual approach likewise apply living beings.Figure 2Infochemicals That Mediate Information Individuals.Show full captionDifferent classes impacts In pheromones conspecifics, allelochemicals different niche.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Different Hormones ubiquitous often structurally highly conserved [8.Lockard M.A. al.Oxytocin mediated behavior invertebrates: perspective.Dev. Neurobiol. 2017; 77: 128-142Crossref (24) Scholar,9.Das D. Arur S. Conserved insulin signaling regulation oocyte growth, development, maturation.Mol. Reprod. Dev. 84: 444-459Crossref (60) indicating phylogenetic history survival, reproduction. Based genetic factors, intriguing intraspecific hormone titers responses among [10.Taff C.C. Vitousek M.N. Endocrine flexibility: optimizing dynamic world?.Trends Evol. 2016; 31: 476-488Abstract Full Text PDF (83) drastic consequences, example, rank positions, mating success, foraging. cases, endocrine cells respond quickly influences thus change secretion seconds minutes. However, duration behavioral hormonal changes vary from (e.g., fight flight responses) months even years organizational effects sexual behavior) [11.Kelly A.M. Dynamic modulation sociality aggression: examination neuroendocrine systems.Philos. Trans. R. Soc. B Sci. 372: 20160243Crossref important drivers 2, Table 1). insects, juvenile entrain choices dependence experienced during certain developmental stage. resource availability horn size dung beetles (Podischnus agenor) choice [12.Eberhard W.G. Beetle dimorphism - making bad lot.Am. 1982; 119: 420-426Crossref locusts Schistocerca gregaria), individual-specific about titers. These influence phase transition solitary gregarious accompanied further behavioral, morphological, [13.Tanaka mechanisms controlling body-color polymorphism locusts.Arch. Insect Biochem. Physiol. 2001; 139-149Crossref (79) Scholar,14.Verlinden H. al.Endocrinology reproduction locusts.Gen. Comp. Endocrinol. 2009; 162: 79-92Crossref (64) vertebrates, titers, especially glucocorticoids, eider ducks (Somateria mollissima) degree corticosterone reactivity nest-site selection, [15.Seltmann al.Boldness stress responsiveness ground-nesting bird.Ethology. 2014; 120: 77-89Crossref (13) Scholar].Table 1Examples Infochemicals Choice, Conformance, Construction IndividualsChemicalsEffectsSpeciesRefsNiche choiceaNote authors respective studies not named construction.HormonesJuvenile hormonesDifferent reproductive strategiesOnthophagus taurusDung beetle[12.Eberhard Scholar]Juvenile hormonesHormone-mediated lifestyleLocusta migratoriaMigratory locust[13.Tanaka Scholar]CorticosteroneLinking departure decision migrateTurdus merulaEuropean blackbird[59.Hegemann al.A perspective ecology evolution partial migration.J. Ornithol. 2019; 160: 893-905Google Scholar]CorticosteroneNest-site selectionSomateria mollissimaEider duck[15.Seltmann Scholar]PheromonesUnknownUsage parts host plantIps duplicatus I. typographusBark beetles[27.Schlyter F. Anderbrant O. Competition separation 2 bark existence mechanisms.Oikos. 1993; 68: 437-447Crossref Scholar]2,6,10-trimethyl-3-oxo-6,10-dodecadienolide unknownOdor preference conspecifics over heterospecificsSaccopteryx bilineata, lepturaSac-winged bats[28.Caspers B. al.Odour-based recognition two sympatric sac-winged bats (Saccopteryx leptura): combining odour tests.Behav. Sociobiol. 63: 741-749Crossref (32) Scholar]UnknownLarval rearing site preferenceRanitomeya variabilisPoison frog[29.Schulte L.M. al.The smell success: larval sites means Peruvian poison frog.Anim. Behav. 2011; 81: 1147-1154Crossref (54) Scholar]UnknownRisk assessment intrusion scent marksMus domesticusHouse mice[31.Hurst J.L. Beynon R.J. Scent wars: chemobiology competitive signalling mice.Bioessays. 2004; 26: 1288-1298Crossref (327) Scholar]AllelochemicalsGlucosinolatesFeeding oviposition stimulants Brassicaceae plantsFeeding specialist herbivores[42.Hopkins al.Role glucosinolates insect-plant relationships multitrophic interactions.Annu. Rev. Entomol. 54: 57-83Crossref (596) Scholar]Volatile contact cuesFeeding preferences plant chemotypesMacrosiphoniella tanacetaria, Uroleucon tanacetiTansy aphids[60.Jakobs Müller C. Volatile, stored phloem exudate-located compounds represent appearance levels affecting aphid choice.Phytochemistry. 159: 1-10Crossref (8) Scholar]Indioside DInduction feeding plantsManduca sextaTobacco hornworm[61.del Campo M.L. al.Host tobacco hornworm compound.Nature. 411: 186-189Crossref (85) Scholar]Dimethyl sulfideFeeding preferencesSea birds[44.Savoca M.S. Nevitt G.A. Evidence dimethyl sulfide facilitates tritrophic mutualism marine primary producers top predators.Proc. Natl. Acad. U. 111: 4157-4161Crossref (66) Scholar]Niche conformanceaNote (JH), diapause (DH)JH regulates ovarian development depending stage at initiated, DH egg silk mothDrosphila melanogaster, Leptinotarsa decemlineata, Bombyx moriVinegar fly, Colorado potato beetle, moth[62.Denlinger D.L. al.Hormonal control diapause.in: Gilbert L.I. Endocrinology. Academic 2012: 430-463Crossref (117) Scholar]Testosterone, cortisolSocial environments adolescence phenotypesCavia aperea f. porcellusGuinea pig[16.Sachser N. adaptive social behavioural adolescence.Biol. Lett. 2018; 14: 20180536Crossref (14) Scholar]GlucocorticoidsNeuroendocrine domesticationCavia aperea, Cavia porcellusWild cavy, guinea pig[63.Kaiser al.Domestication structure, stability biobehavioural profiles.Front. Zool. 12: S19Crossref Scholar]PheromonesUnknownRegulation pheromone perception malesSpodoptera lituraCotton leafworm[34.Zhang Q.H. al.Molecular functional characterization candidate sex receptor OR1 Spodoptera litura.Insect 24: 543-558Crossref (11) Scholar]UnknownGroup odor production after group bacteriaCrocuta crocutaSpotted hyena[36.Theis K.R. al.Evidence bacterial mechanism group-specific odors hyenas.Sci. Rep. 2012; 615Crossref (84) Scholar]AllelochemicalsUnknownDifferential performance plantMacrosiphoniella aphids[45.Jakobs al.Aphid infestation leads part-specific sap chemistry, indicate construction.New Phytol. 221: 503-514Crossref (21) Scholar]Low-molecular weight, non-olefinic hydroxy-carboxylic acidMorphological due presence predator cuesDaphnia pulexWater flea[48.Tollrian Vonelert E. Enrichment purification Chaoborus kairomone water steps towards characterization.Limnol. Oceanogr. 1994; 39: 788-796Crossref Scholar]UnknownInduced defense tadpolesBufo bufoCommon toad tadpole[47.Hettyey al.Predator-induced defence vertebrate.J. Anim. 88: 1925-1935Crossref (9) constructionaNote hormoneCaste determinationApis melliferaHoneybee[64.Huang Z.-Y. honey bee rate biosynthesis.J. 1991; 37: 733-741Crossref (141) hormoneDecision foraging laying foundress associationsPogonomyrmex californicusCalifornian harvester ant[65.Dolezal A.G. al.Worker division labor physiology associated ant, Pogonomyrmex californicus.J. Exp. 215: 454-460Crossref (47) Scholar]Estradiol, progesterone, testosterone, prolactinNest-building behaviorOryctolagus cuniculusRabbit[66.González-Mariscal G. Neuroendocrinology maternal rabbit.Horm. 40: 125-132Crossref (39) Scholar]Mesotocinergic-vasotocinergic systemNest-building behaviorTaeniopygia guttataZebra finch[20.Hall Z.J. nonapeptides dopamine nest-building behaviour.J. Neuroendocrinol. 27: 158-165Crossref (19) Scholar]Pheromones11-Cis-vaccenylacetateGroup aggression, constructionDrosophila melanogasterFruit fly[38.Saltz J.B. Genetic aggressive Drosophila melanogaster.Heredity. 118: 340-347Crossref (15) Scholar]UnknownScent markingMus Scholar]2,5-DimethylpyrazinePuberty delayMus musculus domesticaHouse mice[41.Massey Vandenbergh J.G. Puberty delay urinary cue female house mice feral populations.Science. 1980; 209: 821-822Crossref (52) Scholar]AllelochemicalsQuinonesExternal immune defense, flour quality offspringTribolium castaneumRed beetle[50.Joop al.Experimental external defences red beetle.J. 1562-1571Crossref (28) Scholar]UnknownChanges composition induced feedingUroleucon tanacetiAphids[45.Jakobs Scholar]UnknownNest material selectionSturnus vulgarisStarling[51.Gwinner Berger Starling males select green nest olfaction using experience-independent experience-dependent cues.Anim. 75: 971-976Crossref Scholar]a Note Open table new tab tightly linked; is, immature stages choose niche, later conform, adults specific must adjust. Hormonal could adopt strategy matching size. regulating well pigs (Cavia porcellus). triggers lead [16.Sachser frequency intensity testosterone secretion, influencing cortisol aggression 1B). Individuals low aggressiveness conform situations either queuing strategies, realizing thereby distinct niches. An involvement observed, bees (Megalopta genalis, Bombus impatiens) adjust organization. Dominant females daughters limitation offspring, daughters. make more likely helpers workers reproductives [17.Kapheim K.M. Nutritional, endocrine, origins behavior.Curr. Opin. 62-70Crossref (18) various vertebrate construction, regulated [18.Murakami Distinct estrogen mouse behavior: contribution synthesis brain.PLoS One. 11e0150728Crossref (12) Scholar, 19.González-Mariscal al.Mothers offspring: rabbit model system study mammalian sibling interactions.Horm. 30-41Crossref (37) 20.Hall Given varies [20.Hall level individual. summary, world global changes, ability crucial survival factor Their particularly evident view current discussion (endocrine) traits themselves [21.Trillmich al.Understanding personality requires behind life traits.Biol. 20170740Crossref (20) Pheromones subgroup cause [22.Wyatt T.D. Pheromones.Curr. R739-R740Abstract (29) some terms 'colony cues' 'signature odors' (or mixtures') used instead learned instinctively altered (few) chemical(s) [23.Wyatt Animal Behavior: Chemical Signals Signatures.2nd edn. Cambridge 2014Google simplicity, refer here pheromones. Some signal distances, first identified pheromone, bombykol, released silkworm moths (Bombyx mori) attract [24.Butenandt al.Über den Sexuallockstoff des Seidenspinners mori, Reindarstellung und Konstitution.Z. Naturfor. 1959; 283-284Google Others cuticular hydrocarbons (CHCs) short range, insects [25.Martin Drijfhout review ant hydrocarbons.J. Chem. 35: 1151-1161Crossref (185) Scholar,26.Ingleby F.C. communication.Insects. 6: 732-742Crossref (43) Similar powerful competition avoided responding species-specific aggregation found (Ips typographus) [27.Schlyter ensuring trees. Likewise, decide territories breeding infochemicals. bilineata) prefer vicinity produced heterospecifics [28.Caspers Scholar] 1A). Poison frogs (Ranitomeya variabilis) water-filled cavities plants tadpole [29.Schulte By definition, quantities ratios [30.Karl al.Dissecting underlying old male advantage butterfly.Behav. 2013; 67: 837-849Crossref (16) identity, relatedness, competitiveness [31.Hurst Scholar,32.Stoffel al.Chemical fingerprints encode mother-offspring similarity, colony membership, relatedness fur seals.Proc. 112E5005–5012Crossref Qualitative [33.Lee al.Selection gene flow shape niche-associated response.Nat. 3: 1455-1463Crossref provide flexibility required maintain functioning communication. This conditions, show potentially If divergence increases, isolation occur [34.Zhang differential nestmate labor, task-specific CHC-based queen colonies ants, bees, wasps termites [35.Holman L. Queen labor: 29: 1199-1209Google Group-specific carry vertebrates. groups spotted hyenas (Crocuta crocuta) [36.Theis European badgers (Meles meles) [37.Noonan M.J. al.Knowing me, knowing you: anal gland codes individuality, me
Language: Английский
Citations
69
Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(9), P. 1475 - 1482
Published: Sept. 21, 2023
Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution1,2. In particular, insulin increases sensitivity, but these studies were mainly performed lean men3,4. Here we investigate metabolic hypothalamic effects of women with a focus on impact menstrual cycle ( ClinicalTrials.gov registration: NCT03929419 ).Eleven underwent four hyperinsulinemic-euglycemic clamps, two follicular phase luteal phase. Brain was introduced using nasal spray5-7 compared to placebo spray fourfold crossover design change glucose infusion rate as primary endpoint. show that during phase, more has be infused after administration than placebo. This remains significant adjustment for blood insulin. During no influence is detected (secondary endpoint). 15 other women, sensitivity assessed within-subject by functional magnetic resonance imaging intranasal administration8. Hypothalamus responsivity influenced not phase.Our study therefore highlights improves peripheral also only Thus, resistance could contribute cycle.
Language: Английский
Citations
21