Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation DOI Creative Commons
Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Background Ion channels are essential for differentiation and maturation of germ cells, even fertilization in mammals. Different types potassium have been identified, which grouped into voltage‐gated (Kv), ligand‐gated (K ligand ), inwardly rectifying ir tandem pore domain 2P ). Material‐Methods The present review includes recent findings on the role sperm physiology Results‐Discussion While most studies conducted thus far focused physiological voltage‐ (Kv1, Kv3, Kv7) calcium‐gated (SLO1 SLO3) during capacitation, especially humans rodents, little data about plasma membrane differentiating cells exist. In spite this, evidence suggests that content regulation mechanisms these vary throughout spermatogenesis. Potassium also cell volume epididymal preventing premature hyperpolarization. It is important to highlight nature, biochemical properties, localization, species‐specific. effect, while SLO3 main channel involved K + current capacitation different implicated outflow and, thus, hyperpolarization other mammalian species, such as pigs. Conclusions conductance male fertility, not only but spermiogenesis maturation.

Language: Английский

Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation DOI Creative Commons
Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Background Ion channels are essential for differentiation and maturation of germ cells, even fertilization in mammals. Different types potassium have been identified, which grouped into voltage‐gated (Kv), ligand‐gated (K ligand ), inwardly rectifying ir tandem pore domain 2P ). Material‐Methods The present review includes recent findings on the role sperm physiology Results‐Discussion While most studies conducted thus far focused physiological voltage‐ (Kv1, Kv3, Kv7) calcium‐gated (SLO1 SLO3) during capacitation, especially humans rodents, little data about plasma membrane differentiating cells exist. In spite this, evidence suggests that content regulation mechanisms these vary throughout spermatogenesis. Potassium also cell volume epididymal preventing premature hyperpolarization. It is important to highlight nature, biochemical properties, localization, species‐specific. effect, while SLO3 main channel involved K + current capacitation different implicated outflow and, thus, hyperpolarization other mammalian species, such as pigs. Conclusions conductance male fertility, not only but spermiogenesis maturation.

Language: Английский

Citations

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