Developmental programming of the ovarian reserve in livestock
Animal Reproduction Science,
Journal Year:
2024,
Volume and Issue:
264, P. 107458 - 107458
Published: March 19, 2024
Language: Английский
Beef cows with larger vulvar width have greater antral follicle count, viable oocytes, and higher circulating AMH
Animal Reproduction,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Jan. 1, 2025
Abstract
Owing
to
the
low
heritability
of
reproductive
traits,
search
for
markers
and
their
interrelationship
that
could
indicate
reproductively
superior
individuals
is
important
in
selection
process
bovine
efficiency.
This
study
aimed
investigate
possible
interrelationships
between
antral
follicle
count
(AFC),
vulvar-width
(VW),
anti-Müllerian
hormone
(AMH)
concentrations,
fertility
Bos
Taurus
Indicus
females.
Brahman
(Bos
Taurus-Indicus,
n
=
126)
Simmental
Angus
Taurus-Taurus,
155)
cows
were
classified
as
having
large
(≥86
mm)
small
(<86
VW.
From
each
group,
one
blood
sample
per
animal
was
collected
determine
AMH
serum
concentrations.
The
GLIMMIX
procedure
SAS®
used
whether
vulva
width
(VW)
classes,
associated
or
not
with
breed,
influence
age
at
first
calving
(FCA),
service
interval
(CFSI),
(CI),
number
services
pregnancy
(SP),
viable
oocytes
(VO).
Antral
(AFC)
(36.10
±
1.90
vs.
22.78
1.64,
VW,
respectively),
(1.17
0.07
0.48
0.007
ng/mL),
VO
(18.86
1.76
10.15
1.49)
greater
(P
<
0.05)
VW
than
had
AFC
(36.30
1.34
22.09
1.67),
(106.94
15.83
69.78
14.11
mm),
(1.18
0.42
0.05
ng/mL)
compared
taurine
cows.
In
conclusion,
an
efficient
predictor
concentrations
both
genetic
groups,
but
under
conditions
this
trial
no
link
be
detected
these
variables
indices
studied.
Language: Английский
Maternal age is related to offspring DNA methylation: A meta‐analysis of results from the PACE consortium
Aging Cell,
Journal Year:
2024,
Volume and Issue:
23(8)
Published: May 29, 2024
Abstract
Worldwide
trends
to
delay
childbearing
have
increased
parental
ages
at
birth.
Older
age
may
harm
offspring
health,
but
mechanisms
remain
unclear.
Alterations
in
DNA
methylation
(DNAm)
patterns
could
play
a
role
as
aging
has
been
associated
with
changes
gametes
of
older
individuals.
We
meta‐analyzed
epigenome‐wide
associations
blood
DNAm
over
9500
newborns
and
2000
children
(5–10
years
old)
from
the
Pregnancy
Childhood
Epigenetics
consortium.
In
newborns,
we
identified
33
CpG
sites
13
loci
maternal
(P
FDR
<
0.05).
Eight
these
CpGs
were
located
near/in
MTNR1B
gene,
coding
for
melatonin
receptor.
Regional
analysis
them
together
differentially
methylated
region
consisting
9
in/near
,
which
higher
was
greater
=
6.92
×
10
−8
)
newborns.
childhood
samples,
differences
nominally
significant
(
p
0.05)
retained
same
positive
direction,
suggesting
persistence
associations.
Maternal
also
positively
three
RTEL1‐TNFRSF6B
birth
0.0001).
Of
remaining
persistent
childhood,
cg26709300
YPEL3/BOLA2B
external
data
expression
ITGAL
an
immune
regulator.
While
further
study
is
needed
establish
causality,
particularly
due
small
effect
sizes
observed,
our
results
potentially
support
mechanism
underlying
child
health.
Language: Английский
Proteostasis, Proteodynamics and Cellular Aging
Published: Jan. 1, 2024
During
each
cell's
life,
myriads
of
different,
necessary
proteins
are
manufactured
and
serve
as
interacting
structural
and/or
functional
elements
without
which
the
cell
could
not
function
properly.
Organismal
cellular
aging
imposes
stresses,
constrains
dysfunctions
on
every
stage
protein
manufacturing,
maturation
maintenance,
well
efficiency
removal
those
that
were
malformed
(e.g.
misfolded)
from
beginning
or
during
life
underwent
modifications
leading
e.g.
to
their
aggregation.
Eventually,
these
processes,
included
in
homeostasis
(proteostasis
proteodynamics)
fail
provide
enough
new,
molecules
characterizing
young
becomes
senescent
dies.
Language: Английский