Impact of velocity- and acceleration-compensated encodings on signal dropout and black-blood state in diffusion-weighted magnetic resonance liver imaging at clinical TEs DOI Creative Commons
Tobit Führes, Marc Saake, Filip Szczepankiewicz

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0291273 - e0291273

Published: Oct. 5, 2023

Purpose The study aims to develop easy-to-implement concomitant field-compensated gradient waveforms with varying velocity-weighting ( M 1 ) and acceleration-weighting 2 levels evaluate their efficacy in correcting signal dropouts preserving the black-blood state liver diffusion-weighted imaging. Additionally, we seek determine an optimal degree of compensation that minimizes while maintaining blood suppression. Methods Numerically optimized were adapted using a novel method allows for simultaneous tuning - -weighting by changing only one timing variable. Seven healthy volunteers underwent magnetic resonance imaging (DWI) five diffusion encoding schemes (monopolar, velocity-compensated = 0), acceleration-compensated 84%- – -compensated, 67%- -compensated) at b-values 50 800 s/mm constant echo time 70 ms. Signal dropout correction apparent coefficients (ADCs) quantified regions interest left right lobe. appearance was evaluated two five-point Likert scales. Results more pronounced lobe (19%-42% less than monopolar scheme) best corrected acceleration-compensation (8%-10% lobe). encodings decreased significantly (p < 0.001) velocity- and/or acceleration-compensation. partially -compensated could restore again. Strongest ADC bias occurred (difference between left/right 0.41 μm /ms vs. 0.12 other encodings). Conclusion All used this demonstrated suitability routine DWI application. results indicate perfect value level -compensation does not exist. However, among examined encodings, provided suitable tradeoff.

Language: Английский

In vivo diffusion MRI of the human heart using a 300 mT/m gradient system DOI Creative Commons
Maryam Afzali, Lars Mueller, Sam Coveney

et al.

Magnetic Resonance in Medicine, Journal Year: 2024, Volume and Issue: 92(3), P. 1022 - 1034

Published: April 22, 2024

This work reports for the first time on implementation and application of cardiac diffusion-weighted MRI a Connectom MR scanner with maximum gradient strength 300 mT/m. It evaluates benefits increased performance investigation myocardial microstructure.

Language: Английский

Citations

5
Cardiac diffusion-weighted and tensor imaging: a Society for Cardiovascular Magnetic Resonance (SCMR) special interest group consensus statement DOI Creative Commons
Erica Dall’Armellina, Daniel B. Ennis, Leon Axel

et al.

Journal of Cardiovascular Magnetic Resonance, Journal Year: 2024, Volume and Issue: 27(1), P. 101109 - 101109

Published: Oct. 22, 2024

Language: Английский

Citations

3
Cardiac q‐space trajectory imaging by motion‐compensated tensor‐valued diffusion encoding in human heart in vivo DOI Creative Commons
Irvin Teh,

David Shelley,

Jordan H. Boyle

et al.

Magnetic Resonance in Medicine, Journal Year: 2023, Volume and Issue: 90(1), P. 150 - 165

Published: March 20, 2023

Purpose Tensor‐valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional weighting. In this work, we investigate the technical feasibility tensor‐valued at high b ‐values with q‐space trajectory imaging (QTI) analysis, in human heart vivo. Methods Ten healthy volunteers were scanned on a 3T scanner. We designed time‐optimal gradient waveforms for (linear and planar) second‐order motion compensation. Data analyzed QTI. Normal values repeatability investigated mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic total kurtosis (MKi, MKa, MKt), orientation coherence ( C c ). A phantom, consisting two fiber blocks adjustable angles, was used to evaluate sensitivity parameters dispersion time. Results QTI data left ventricular myocardium MD = 1.62 ± 0.07 μm 2 /ms, 0.31 0.03, μFA 0.43 0.07, MKa 0.20 MKi 0.13 MKt 0.33 0.09, 0.56 0.22 (mean SD across subjects). Phantom experiments showed that depends dispersion, whereas insensitive effect. Conclusion demonstrated first analysis vivo, along measurements myocardial μFA, MKi, . The methodology technically feasible provides promising novel biomarkers characterization.

Language: Английский

Citations

4
Impact of velocity- and acceleration-compensated encodings on signal dropout and black-blood state in diffusion-weighted magnetic resonance liver imaging at clinical TEs DOI Creative Commons
Tobit Führes, Marc Saake, Filip Szczepankiewicz

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0291273 - e0291273

Published: Oct. 5, 2023

Purpose The study aims to develop easy-to-implement concomitant field-compensated gradient waveforms with varying velocity-weighting ( M 1 ) and acceleration-weighting 2 levels evaluate their efficacy in correcting signal dropouts preserving the black-blood state liver diffusion-weighted imaging. Additionally, we seek determine an optimal degree of compensation that minimizes while maintaining blood suppression. Methods Numerically optimized were adapted using a novel method allows for simultaneous tuning - -weighting by changing only one timing variable. Seven healthy volunteers underwent magnetic resonance imaging (DWI) five diffusion encoding schemes (monopolar, velocity-compensated = 0), acceleration-compensated 84%- – -compensated, 67%- -compensated) at b-values 50 800 s/mm constant echo time 70 ms. Signal dropout correction apparent coefficients (ADCs) quantified regions interest left right lobe. appearance was evaluated two five-point Likert scales. Results more pronounced lobe (19%-42% less than monopolar scheme) best corrected acceleration-compensation (8%-10% lobe). encodings decreased significantly (p < 0.001) velocity- and/or acceleration-compensation. partially -compensated could restore again. Strongest ADC bias occurred (difference between left/right 0.41 μm /ms vs. 0.12 other encodings). Conclusion All used this demonstrated suitability routine DWI application. results indicate perfect value level -compensation does not exist. However, among examined encodings, provided suitable tradeoff.

Language: Английский

Citations

4