Physical and Respiratory Rehabilitation in Spinal Muscular Atrophy: A Critical Narrative Review DOI Creative Commons

Serena Cammarano,

Vincenzo Alessio Chirico, Benedetto Giardulli

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4398 - 4398

Published: April 16, 2025

Spinal muscular atrophy (SMA) is a genetic disorder causing motor neuron loss and progressive muscle weakness, significantly affecting daily activities breathing in severe cases. While rehabilitation crucial component of SMA management, no standardised guidelines currently exist. This review synthesised physiotherapy respiratory interventions for patients based on comprehensive literature search from 1990 to 2024. Eighteen studies were analysed: eleven seven rehabilitation. Five approaches reported: electrical stimulation, electrotherapy with cycling, strengthening exercises, aerobic training, hydrotherapy-based Respiratory interventions, such as non-invasive ventilation cough assistance, mainly studied Type I, reporting prolonged survival improved function. A few found that combining pharmacotherapy intensive led better improvements than drugs alone. Despite these promising reported results, the lack methodologies long-term clinical trials prevents definitive conclusions. Research should prioritise randomised controlled trial larger sample sizes investigate efficacy and, secondly, inform evidence-based protocols guidelines.

Language: Английский

Physical and Respiratory Rehabilitation in Spinal Muscular Atrophy: A Critical Narrative Review DOI Creative Commons

Serena Cammarano,

Vincenzo Alessio Chirico, Benedetto Giardulli

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4398 - 4398

Published: April 16, 2025

Spinal muscular atrophy (SMA) is a genetic disorder causing motor neuron loss and progressive muscle weakness, significantly affecting daily activities breathing in severe cases. While rehabilitation crucial component of SMA management, no standardised guidelines currently exist. This review synthesised physiotherapy respiratory interventions for patients based on comprehensive literature search from 1990 to 2024. Eighteen studies were analysed: eleven seven rehabilitation. Five approaches reported: electrical stimulation, electrotherapy with cycling, strengthening exercises, aerobic training, hydrotherapy-based Respiratory interventions, such as non-invasive ventilation cough assistance, mainly studied Type I, reporting prolonged survival improved function. A few found that combining pharmacotherapy intensive led better improvements than drugs alone. Despite these promising reported results, the lack methodologies long-term clinical trials prevents definitive conclusions. Research should prioritise randomised controlled trial larger sample sizes investigate efficacy and, secondly, inform evidence-based protocols guidelines.

Language: Английский

Citations

0