The glymphatic system

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 170

Published: Jan. 1, 2025

Language: Английский

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Recent Developments and Future Perspectives in Magnetic Resonance Imaging and Computed Tomography Contrast Media

Investigative Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract This review provides a comprehensive analysis of recent advancements in computed tomography (CT) and magnetic resonance imaging (MRI) contrast media, offering critical evaluation current trends exploring future directions the field. New clinical developments within last 5–8 years are considered as well efficacy safety aspects. For CT, general low- iso-osmolar iodinated agents their effect on renal thyroid function reviewed. Special attention is given to contrast-enhanced mammography short outlook photon-counting CT provided. MRI, brief update safety, nephrogenic systemic fibrosis presence gadolinium brain given. The 2 new high-relaxivity gadolinium-based agents, gadopiclenol gadoquatrane (in late-stage development), highlighted. also describes targeted superparamagnetic iron oxide particles, manganese-based agents. It introduces emerging field glymphatic imaging.

Language: Английский

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Longitudinal assessment of glymphatic changes following mild traumatic brain injury: Insights from perivascular space burden and DTI-ALPS imaging

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 7, 2024

Introduction Traumatic brain injury (TBI) even in the mild form may result long-lasting post-concussion symptoms. TBI is also a known risk to late-life neurodegeneration. Recent studies suggest that dysfunction glymphatic system, responsible for clearing protein waste from brain, play pivotal role development of dementia following TBI. Given diverse nature TBI, longitudinal investigations are essential comprehending dynamic changes system and its implications recovery. Methods In this prospective study, we evaluated two promising imaging markers, namely enlarged perivascular space (ePVS) burden Diffusion Tensor Imaging-based ALPS index, 44 patients with mTBI at early post-injury time points: approximately 14 days (14Day) 6–12 months (6–12Mon) post-injury, while examining their associations Additionally, 37 controls, comprising both orthopedic healthy individuals, were included comparative analysis. Results Our key findings include: (1) White matter ePVS (WM-ePVS) index exhibit significant correlations age. (2) Elevated WM-ePVS acute significantly linked higher number symptoms, particularly memory problems. (3) The increase chronic phases correlates improvement sleep measures. Furthermore, incorporating phase enhances prediction problems beyond socio-demographic basic clinical information. Conclusion offers distinct values assessing structure activity. Early evaluation function could be crucial understanding recovery developing targeted interventions improve patient outcomes.

Language: Английский

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Longitudinal Assessment of Glymphatic Changes Following Mild Traumatic Brain Injury: Insights from PVS burden and DTI-ALPS Imaging

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 2, 2024

Traumatic brain injury (TBI) even in the mild form may result long-lasting post-concussion symptoms. TBI is also a known risk to late-life neurodegeneration. Recent studies suggest that dysfunction glymphatic system, responsible for clearing protein waste from brain, play pivotal role development of dementia following TBI. Given diverse nature TBI, longitudinal investigations are essential comprehending dynamic changes system and its implications recovery. In this prospective study, we evaluated two promising imaging markers, namely enlarged perivascular space (ePVS) burden Diffusion Tensor Imaging-based ALPS index, 44 patients with mTBI at early post-injury time points: approximately 14 days (14Day) 6-12 months (6-12Mon) post-injury, while examining their associations Additionally, 37 controls, comprising both orthopedic healthy individuals, were included comparative analysis. Our key findings include: 1) White matter ePVS (WM-ePVS) index exhibit significant correlations age. 2) Elevated WM-ePVS acute significantly linked higher number symptoms, particularly memory problems. 3) The increase chronic phases correlates improvement sleep measures. Furthermore, incorporating phase enhances prediction problems beyond socio-demographic basic clinical information, highlighting distinct roles assessing structure activity. Early evaluation function could be crucial understanding recovery developing targeted interventions improve patient outcomes.

Language: Английский

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Lymphatic System of the Brain

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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