Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development DOI Open Access
Sarmin Ummey Habiba,

Ho Jin Choi,

Yeasmin Akter Munni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12701 - 12701

Published: Nov. 26, 2024

Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused its neurotrophic impact, particularly neuronal maturation synaptic development. This study investigates the of F. ethanol extracts (FVSE) rat primary hippocampal neurons. Results show that FVSE prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal dendritic growth occurred at concentrations 40 µg/mL 20 µM respectively, without causing cytotoxicity, underscoring safety health. Additionally, enhances formation synapses, essential communication. Network pharmacology analysis revealed components influence critical pathways, including PI3K-AKT Alzheimer’s disease pathways. Specifically, modulates key proteins, tropomyosin receptor kinase (Trk), glycogen synthase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated protein (Erk1/2). Anethole was found to play role regulating these which confirmed by immunocytochemistry experiments demonstrating effect promoting In conclusion, this highlights properties FVSE, anethole emerging bioactive compound. These findings provide valuable insights into fennel treating disorders, offering basis future interventions survival.

Language: Английский

BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases DOI
Smijin Soman, Maryann Swain, Ruben K. Dagda

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Language: Английский

Citations

12
Intermittent fasting and neurocognitive disorders: What the evidence shows DOI Creative Commons

J. M. R. Beveridge,

A.M.J. Montgomery,

George T. Grossberg

et al.

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(4), P. 100480 - 100480

Published: Jan. 10, 2025

Language: Английский

Citations

0
Plasma Metabolites as Mediators Between Gut Microbiota and Parkinson’s Disease: Insights from Mendelian Randomization DOI

Jianzhun Chen,

Liuhui Zhu,

Fang Wang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders DOI Creative Commons
Alka Ashok Singh,

Sadhana Katiyar,

Minseok Song

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 252 - 252

Published: Feb. 27, 2025

Neurological disorders are defined by a deterioration or disruption of the nervous system’s structure and function. These diseases, which include multiple sclerosis, Alzheimer’s disease, Parkinson’s Huntington’s schizophrenia, caused intricate pathological processes that excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, compromised neurotrophic signaling. Although current pharmaceutical treatments relieve symptoms, their long-term efficacy is limited due to adverse side effects weak neuroprotective properties. However, when combined with other drugs adjunct therapy, they may offer additional benefits improve treatment outcomes. Phytochemicals have emerged as attractive therapeutic agents ability regulate essential pathways, especially brain-derived factor (BDNF) signaling cascade. BDNF an important target for neurodegenerative disease (ND) since it regulates neuronal survival, synaptic plasticity, neurogenesis, neuroprotection. This review emphasizes molecular pathways through various phytochemicals—such flavonoids, terpenoids, alkaloids, phenolic compounds—stimulate expression modulate its downstream including GSK-3β, MAPK/ERK, PI3K/Akt/mTOR, CREB, Wnt/β-catenin. paper also highlights how phytochemical combinations interact enhance activity, offering new options ND treatment. Despite potential neuroprotection, phytochemicals face challenges related pharmacokinetics, blood–brain barrier (BBB) permeability, absorption, highlighting need further research into combination therapies improved formulations. Clinical assessment mechanistic understanding BDNF-targeted phytotherapy should be main goals future studies. The natural compounds in regulating highlighted this review, providing viable approach prevention NDs.

Language: Английский

Citations

0
Deciphering the Neuroprotective Action of Bee Venom Peptide Melittin: Insights into Mechanistic Interplay DOI
Pankaj Kadyan, Lovedeep Singh

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development DOI Open Access
Sarmin Ummey Habiba,

Ho Jin Choi,

Yeasmin Akter Munni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12701 - 12701

Published: Nov. 26, 2024

Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused its neurotrophic impact, particularly neuronal maturation synaptic development. This study investigates the of F. ethanol extracts (FVSE) rat primary hippocampal neurons. Results show that FVSE prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal dendritic growth occurred at concentrations 40 µg/mL 20 µM respectively, without causing cytotoxicity, underscoring safety health. Additionally, enhances formation synapses, essential communication. Network pharmacology analysis revealed components influence critical pathways, including PI3K-AKT Alzheimer’s disease pathways. Specifically, modulates key proteins, tropomyosin receptor kinase (Trk), glycogen synthase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated protein (Erk1/2). Anethole was found to play role regulating these which confirmed by immunocytochemistry experiments demonstrating effect promoting In conclusion, this highlights properties FVSE, anethole emerging bioactive compound. These findings provide valuable insights into fennel treating disorders, offering basis future interventions survival.

Language: Английский

Citations

0