The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177510 - 177510

Published: March 1, 2025

Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine attenuating the development of oxidative stress associated neurotoxicity. HN protects neuron from toxic effects amyloid beta (Aβ). regarded biomarker mitochondrial stress. Interestingly, aging reduces brain expression HN, leading to cognitive impairment elevating risk neurodegeneration, including AD. However, in old subjects AD patients, circulating levels increase compensatory mechanism reduce neurodegeneration dysfunction Conversely, studies demonstrated reduction These findings indicated controversial points regarding precise mechanistic role Therefore, aim this review was discuss exact neuropathology molecular mechanisms

Language: Английский

Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103600 - 103600

Published: March 1, 2025

Language: Английский

Insight into the Mechanistic role of Colchicine in Atherosclerosis

Current Atherosclerosis Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 20, 2025

Language: Английский