Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

The obesity epidemic has become a global public health issue, impacting more than one billion people worldwide. 9% of the US population, or 28.8 million Americans will have an eating disorder in their lifetime. In fact, prevalence increased from 3.5% to 7.8% between 2000 and 2018. spite fact that less 6% with are medically underweight, it is indeed important factor when considering issues related obesity. This problem often described as being caused by various genetic psychosocial factors. One most effective strategies for treating morbid achieving significant weight loss bariatric surgery. Recent focus on precision medicine approaches expanded into surgery effort better understand achieve improved outcomes reduce risk post-operative regain addiction transfers during recovery process. Addiction transfers, including substance non-substance addictions, well established concerns post-bariatric patients. review details genetic, molecular factors can be utilized inform guide personalized treatment. Additionally, this some mechanisms dysregulation catecholamine signaling other neurotransmitter systems relevant help further science.

Language: Английский

Dynamic fronto‐amygdalar interactions underlying emotion‐regulation deficits in women at higher weight

Obesity, Journal Year: 2023, Volume and Issue: 31(9), P. 2283 - 2293

Published: Aug. 6, 2023

Abstract Objective The regulation of negative emotions entails the modulation subcortical regions, such as amygdala, by prefrontal regions. There is preliminary evidence suggesting that individuals at higher weight may present with hypoactivity in regulatory systems during emotional regulation, although directionality these pathways has not been tested. In this study, we compared fronto‐amygdalar effective connectivity cognitive reappraisal a function BMI 48 adult women obesity and 54 control participants. Methods Dynamic causal modeling parametric empirical Bayes were used to map between dorsomedial cortex, orbitofrontal dorsolateral amygdala. Results Difficulty Emotion Regulation Scale scores group participants ( p < 0.001). A top‐down cortical model best explained our functional magnetic resonance imaging data (posterior probability = 86%). Participants less inhibiting activity amygdala via cortex those lower BMI. contrast, increased excitatory cortex‐to‐amygdalar was found Conclusions These findings support framework involving alterations contributing difficulties regulating affect weight.

Language: Английский

Distinct functional connectivity phenotypes in preadolescent children with binge eating disorder by BMI status

Obesity, Journal Year: 2024, Volume and Issue: 32(11), P. 2082 - 2086

Published: Oct. 10, 2024

The neurobiological mechanisms underpinning binge eating disorder (BED) in children remain largely unclear, as the alterations that have been identified to date may be attributable BED, obesity, or compound effects. This study aimed delineate functional connectivity (FC) patterns inhibitory control and reward networks preadolescent with without BED from Adolescent Brain Cognitive Development (ABCD) Study according BMI.

Language: Английский