Modeling mechanisms driving metabolic benefits of time‐restricted eating DOI
Susan K. Fried

Obesity, Journal Year: 2024, Volume and Issue: 32(9), P. 1609 - 1610

Published: July 28, 2024

Eating frequently over waking hours leads to constant levels of metabolic hormones and substrates that may drive systemic insulin resistance dysfunction. In contrast, accumulating evidence suggests consuming food at discrete times (i.e., meals) promotes flexibility health. Time-restricted eating (TRE), early compared with late in the day, is hypothesized promote mobilization fat, but mechanisms involved remain poorly understood. this issue Obesity, Zambrano et al. [(1)] use a cell culture model address timely important topic. initiates shifts metabolism storage dietary fat as triacylglycerol suppress its (lipolysis). fasted state, lower combined short-term increases neural input mobilize triglyceride stores lead release nonesterified fatty acids glycerol provide fuel for peripheral tissues such muscle while sparing glucose brain. Adipocytes integrate these other hormonal signals regulate tissue metabolic, immune, secretory functions maintain [(2, 3)]. These ingestion-related factors are superimposed on cell-autonomous circadian oscillations [(4)]. Additionally, multiple types (including immune) within adipose modulate paracrine microenvironment. Therefore, design cell- tissue-based experiments complex vivo systems exceedingly challenging. To TRE, obtained abdominal subcutaneous from surgeries severe obesity. They several quality control measures: limiting timing sample collection; using small fragments cultured ex vivo; synchronizing rhythms dexamethasone treatment 1 h followed by 1-h washout. they feeding schedule 16 "feeding" standard medium (10% fetal bovine serum [FBS] DMEM) during "light" "fasting" next 8 (modeling dark/sleeping). Fasting was modeled media without any FBS. The accumulation into assessed every 4 day 2. Their main finding increased time since last vitro "meal," well illustrated Figure S1. Several features limit strength authors' conclusions. physiological relevance 0 FBS starvation 10% 25mM not discussed. group's prior studies, extremes concentration were avoided [(3)]. Additional components also impact results should be considered [(5)]. investigators did consider modeling variations key (insulin, cortisol) or acute response catecholamine-stimulated lipolysis, which contribute mobilization. Finally, it whether initial "in vivo" enzymes hormone responsiveness maintained 2 days cultures. simple measurement basal provides only limited insight lipolysis. Assessment steps protein lipase, sensitive lipid droplet perilipin, their phosphorylation future studies. conclusion, report highlights potential role lipolysis mediating effects TRE health, challenges complexity studying nutritional regulation vitro. author declared no conflict interest.

Language: Английский

The relationship between chrononutrition profile, social jet lag and obesity: A cross-sectional study of Chinese college students DOI

Yue Gong,

Jixin Zhang, Shengnan Li

et al.

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 11, 2025

This study aimed to investigate the associations between chrononutrition profile, social jet lag (SJL) with obesity-related indicators (body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and percentage of body fat (PBF)). cross-sectional was conducted among college students in a university Hunan Province, China, from 14 September 2023 8 June 2024. employed Chrononutrition Profile – Questionnaire (CP-Q) along physical examinations. SJL defined as time difference midpoint sleep workdays freedays. Sleep-corrected (SJLsc) is absolute onset on free days workdays. Average evening latency last meal day bedtime. Eating eating window Logistic regression utilized assess SJL, students. A total 805 participants were recruited, which 695 have complete data after excluding those who did not meet inclusion criteria. After adjusting for potential covariates, average <4 h related lower risk high BMI, WC, PBF [OR (95% CI) = 0.435 (0.285–0.663), 0.508 (0.305–0.848), 0.564 (0.402–0.792), respectively]. >12 associated 0.511 (0.327–0.800), 0.485 (0.277–0.851), 0.651 (0.456–0.930), Last occasion >1 higher 1.554 (1.018–2.371)]. SJLsc > 1 1.527 (1.073–2.174)]. Circadian rhythm disruptions, including lag, are prevalent Long window, short latency, low obesity, while duration, larger obesity youths.

Language: Английский

Citations

0
Beyond the Scales: A Qualitative Study on the Biopsychosocial Impacts of Time-Restricted Eating in Free-Living Individuals DOI Creative Commons
Hilmi Sulaiman Rathomi, Nahal Mavaddat, Judith Katzenellenbogen

et al.

Obesities, Journal Year: 2025, Volume and Issue: 5(1), P. 10 - 10

Published: Feb. 18, 2025

Time-restricted eating (TRE) has gained attention as an effective approach for weight management and overall well-being by focusing on limiting the window, rather than reducing calories. This study explores biopsychosocial impacts of TRE in free-living individuals using a qualitative design. Twenty-one adults (aged 27–60 years) from Western Australia who had practised at least three months were purposively recruited, semi-structured interviews conducted. The data analysed thematic analysis to identify key themes. participants reported range benefits, including loss, reduced joint pain, better digestion, improved mental clarity, increased energy, more positive body image. Socially, facilitated simplified daily routines but also introduced challenges, such disruptions social interactions family meal dynamics. Some mixed negative reported, changes sleep exercise patterns. These findings highlight TRE’s potential holistic dietary intervention. Further research, particularly well-controlled, randomised controlled trials longitudinal studies, is needed confirm these insights guide their appropriate application clinical public health settings.

Language: Английский

Citations

0
Modeling mechanisms driving metabolic benefits of time‐restricted eating DOI
Susan K. Fried

Obesity, Journal Year: 2024, Volume and Issue: 32(9), P. 1609 - 1610

Published: July 28, 2024

Eating frequently over waking hours leads to constant levels of metabolic hormones and substrates that may drive systemic insulin resistance dysfunction. In contrast, accumulating evidence suggests consuming food at discrete times (i.e., meals) promotes flexibility health. Time-restricted eating (TRE), early compared with late in the day, is hypothesized promote mobilization fat, but mechanisms involved remain poorly understood. this issue Obesity, Zambrano et al. [(1)] use a cell culture model address timely important topic. initiates shifts metabolism storage dietary fat as triacylglycerol suppress its (lipolysis). fasted state, lower combined short-term increases neural input mobilize triglyceride stores lead release nonesterified fatty acids glycerol provide fuel for peripheral tissues such muscle while sparing glucose brain. Adipocytes integrate these other hormonal signals regulate tissue metabolic, immune, secretory functions maintain [(2, 3)]. These ingestion-related factors are superimposed on cell-autonomous circadian oscillations [(4)]. Additionally, multiple types (including immune) within adipose modulate paracrine microenvironment. Therefore, design cell- tissue-based experiments complex vivo systems exceedingly challenging. To TRE, obtained abdominal subcutaneous from surgeries severe obesity. They several quality control measures: limiting timing sample collection; using small fragments cultured ex vivo; synchronizing rhythms dexamethasone treatment 1 h followed by 1-h washout. they feeding schedule 16 "feeding" standard medium (10% fetal bovine serum [FBS] DMEM) during "light" "fasting" next 8 (modeling dark/sleeping). Fasting was modeled media without any FBS. The accumulation into assessed every 4 day 2. Their main finding increased time since last vitro "meal," well illustrated Figure S1. Several features limit strength authors' conclusions. physiological relevance 0 FBS starvation 10% 25mM not discussed. group's prior studies, extremes concentration were avoided [(3)]. Additional components also impact results should be considered [(5)]. investigators did consider modeling variations key (insulin, cortisol) or acute response catecholamine-stimulated lipolysis, which contribute mobilization. Finally, it whether initial "in vivo" enzymes hormone responsiveness maintained 2 days cultures. simple measurement basal provides only limited insight lipolysis. Assessment steps protein lipase, sensitive lipid droplet perilipin, their phosphorylation future studies. conclusion, report highlights potential role lipolysis mediating effects TRE health, challenges complexity studying nutritional regulation vitro. author declared no conflict interest.

Language: Английский

Citations

0