The role of gut microbiota in predicting the weight loss following laparoscopic sleeve gastrectomy DOI Creative Commons
Jionghuang Chen, Bo Shen,

Hongdan Shen

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background Laparoscopic sleeve gastrectomy (LSG) has emerged as a highly effective intervention in the management of obesity. While there been recent surge research exploring relationship between obesity and gut microbiota, association microbiota LSG remains relatively underexplored. This study aimed to investigate both early later effects LSG. Methods In this retrospective study, clinical characteristics preoperative fecal samples were collected from 52 individuals who underwent Using 16S rRNA gene sequencing, we compared community composition, alpha diversity, beta diversity patients experienced efficient weight loss those did not. Additionally, comprehensive correlation analyses performed identify potential associations specific microbial taxa outcomes. Results The abundances general comparable. However, influence on efficacy is dynamic. Specifically, Fusobacteriota phylum significantly contributed curative LSG, while Actinobacteriota had greater impact late effects. Proteobacteria found mediate long-term through complex mechanisms. Conclusion analyzed signature predict potentially offering valuable insights for applications. Preoperative assessment profiles could assist their decision-making processes, particularly regarding outcomes procedure health.

Language: Английский

The role of gut microbiota in predicting the weight loss following laparoscopic sleeve gastrectomy DOI Creative Commons
Jionghuang Chen, Bo Shen,

Hongdan Shen

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background Laparoscopic sleeve gastrectomy (LSG) has emerged as a highly effective intervention in the management of obesity. While there been recent surge research exploring relationship between obesity and gut microbiota, association microbiota LSG remains relatively underexplored. This study aimed to investigate both early later effects LSG. Methods In this retrospective study, clinical characteristics preoperative fecal samples were collected from 52 individuals who underwent Using 16S rRNA gene sequencing, we compared community composition, alpha diversity, beta diversity patients experienced efficient weight loss those did not. Additionally, comprehensive correlation analyses performed identify potential associations specific microbial taxa outcomes. Results The abundances general comparable. However, influence on efficacy is dynamic. Specifically, Fusobacteriota phylum significantly contributed curative LSG, while Actinobacteriota had greater impact late effects. Proteobacteria found mediate long-term through complex mechanisms. Conclusion analyzed signature predict potentially offering valuable insights for applications. Preoperative assessment profiles could assist their decision-making processes, particularly regarding outcomes procedure health.

Language: Английский

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