Green Synthesis of Bisindolylmethane Derivatives (A Review) DOI
Hala B. El‐Nassan

Russian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 60(S1), P. S9 - S21

Published: Dec. 1, 2024

Language: Английский

Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes DOI
Pankaj Teli, Shivani Soni, Sunita Teli

et al.

Topics in Current Chemistry, Journal Year: 2024, Volume and Issue: 382(1)

Published: Feb. 25, 2024

Language: Английский

Citations

13
Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide DOI Creative Commons
A. Sofia Santos,

Rita Ferro,

Nuno Viduedo

et al.

ChemistryOpen, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are subgroup indoles, composed two units. Herein, we report the development simple method to access BIMs derivatives yields up 77 % by exploiting tBuOK-mediated coupling reaction indoles benzyl alcohols.

Language: Английский

Citations

10
LiOtBu-promoted synthesis of bis(3-indolyl)methanes by the alkylation of indoles with alcohols under air DOI Creative Commons
Nguyen Hai Yen,

Thu Hue Tran,

Ha Nam

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(4), P. 2341 - 2345

Published: Jan. 1, 2024

Bis(3-indolyl)methanes (BIMs) are known for their important bioactivities, which include anti-cancer, anti-inflammatory, antibacterial, and antioxidant properties. In this study, we disclosing a metal catalyst-free synthesis of BIMs in high yields via the alkylation reaction indoles alcohols presence lithium tert-butoxide base. Notably, oxygen air played an role as oxidant facilitation transformation. Interestingly, unactivated aliphatic could be successfully used alkylating reagents reactions indole. Especially, several chemical intermediates detected by GC-MS gave information about mechanism insights. This method demonstrated cost environmental advantages development green processes.

Language: Английский

Citations

3
Divergence in CH alkylation of indoles under Mn catalysis DOI Creative Commons
Akash Mondal, Rohit Kumar,

Abhijith Karattil Suresh

et al.

Catalysis Science & Technology, Journal Year: 2023, Volume and Issue: 13(19), P. 5745 - 5756

Published: Jan. 1, 2023

We report manganese-catalyzed CH alkylation of indole/indolines with alcohols, where catalyst control provides product selectivity. synthesise several life science molecules (vibrindole A, turbomycin B alkaloid and antileukemic anticancer agents).

Language: Английский

Citations

7
Lewis Acid-catalyzed Regioselective Addition of Allenoates to Indoles for Synthesis of Bisindolylesters DOI

Fuyu Xie,

Jianghua He, Yuetao Zhang

et al.

Chemical Research in Chinese Universities, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Language: Английский

Citations

1
Exploring Thermomyces lanuginosus Lipase (TLL)‐PdNPs Nanohybrid as Suitable Catalyst for One‐pot Synthesis of Bis(3‐indolyl)phenylmethane DOI Creative Commons
A. Sofia Santos, Noelia Losada‐Garcia, Carla Garcia‐Sanz

et al.

ChemCatChem, Journal Year: 2023, Volume and Issue: 16(3)

Published: Nov. 27, 2023

Abstract Palladium nanohybrids were synthesized and applied to the one‐pot synthesis of bis(3‐indolyl)methanes by selective C−C bond reaction from benzyl alcohol indole. A T. lanuginosus lipase‐palladium nanoparticles hybrid (Pd@TLL) was synthesized, yielding PdNPs with an average diameter size 5 nm. This heterogeneous catalyst first tested in oxidation benzaldehyde different solvents. Then, direct formation bis(3‐indolyl)methane, situ coupling, successfully evaluated under conditions, obtaining >99 % conversion at 80 °C toluene, a TOF value 9 min −1 89 pure water , demonstrating versatility these biohybrids.

Language: Английский

Citations

2
Diaryliodonium Salt‐Mediated Radical Transformation of Indoles with Alcohols for the Synthesis of Unsymmetrical Bis(indolyl)methanes DOI
Zhen Wang,

Haohao Jiang,

Shuizhen Lin

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract A method for the synthesis of unsymmetrical bis(indolyl)methanes (BIMs) using simple indoles and readily available alcohols as coupling partners under both heat 390–400 nm light conditions was developed. Detailed research mechanism demonstrated that diaryliodonium salt‐mediated transformation undergoes a nucleophilic hydroxymethyl radical formation process. Moreover, is also applicable synthesizing symmetrical BIMs.

Language: Английский

Citations

0
Cascade approach to synthesize BIMs and analogues in different nucleophilic conditions DOI

Kailas Arjun Chavan,

Prakash N. Chavan,

Akhilesh Kumar

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 148, P. 155248 - 155248

Published: Aug. 11, 2024

Language: Английский

Citations

0
An effective alliance for successful coupling: electrochemical alcohol oxidation mediated conversion of indoles to bis(indolyl)methanes DOI

Mayur D. Baravkar,

B. L. V. Prasad

Journal of Applied Electrochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

Citations

0
Green Synthesis of Bisindolylmethane Derivatives (A Review) DOI
Hala B. El‐Nassan

Russian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 60(S1), P. S9 - S21

Published: Dec. 1, 2024

Language: Английский

Citations

0