Molecules,
Journal Year:
2024,
Volume and Issue:
30(1), P. 107 - 107
Published: Dec. 30, 2024
Herein,
we
report
the
synthesis
of
a
series
new
compounds
by
combining
2-aminobenzothiazole
with
various
profens.
The
were
characterized
using
techniques
such
as
1H-
and
13C-NMR,
FT-IR
spectrometry,
high-resolution
mass
spectrometry
(HRMS),
detailed
HRMS
analysis
conducted
for
each
molecule.
Their
biological
activities
tested
in
vitro,
revealing
significant
anti-inflammatory
antioxidant
effects,
comparable
to
those
standard
reference
compounds.
Lipophilicity
was
experimentally
determined
through
partition
coefficient
(RM)
measurements.
To
understand
their
binding
affinity,
molecular
docking
studies
perfsormed
analyze
interactions
human
serum
albumin
(HSA).
stability
these
predicted
complexes
further
evaluated
dynamics
simulations.
results
highlight
compounds’
promising
activity
strong
affinity
HSA.
hybrid
molecule
between
2-ABT
ketoprofen
3b
demonstrates
promise
based
on
experimental
data
is
supported
silico
calculations.
Compound
exhibits
best
hydrogen
peroxide
scavenging
among
compounds,
an
IC50
60.24
μg/mL.
Furthermore,
also
displays
superior
activity,
54.64
μg/mL,
making
it
more
effective
than
ibuprofen
(76.05
μg/mL).
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(4), P. 2334 - 2346
Published: Jan. 1, 2025
Benzo-fused
γ-lactams
are
fundamental
in
medicinal
chemistry,
acting
as
essential
elements
for
various
therapeutic
agents
due
to
their
structural
adaptability
and
capability
enhance
biological
activity.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3928 - 3953
Published: Jan. 1, 2025
This
review
studies
magnetically
recoverable
catalysts
designed
for
the
efficient
multicomponent
synthesis
of
organosulfur
compounds.
These
enhance
process
by
combining
efficiency
with
environmental
sustainability.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 3, 2025
In
the
last
10
years,
synthesis
of
anthracene
scaffolds
has
attracted
considerable
interest
because
their
distinctive
electronic
characteristics
and
various
uses
in
organic
electronics,
photovoltaics,
therapeutics.
Anthracene,
a
polycyclic
aromatic
hydrocarbon,
is
valued
for
its
lightweight,
stability,
electron
transport
capabilities,
making
it
key
building
block
advanced
materials.
Traditional
methods
often
face
challenges
such
as
low
selectivity
harsh
conditions.
However,
recent
advancements
transition
metal-catalyzed
reactions
have
transformed
field,
offering
more
efficient
versatile
approaches.
This
review
examines
methodologies
utilizing
metal
catalysts
like
palladium,
zinc,
indium,
cobalt,
gold,
iridium,
rhodium
ruthenium,
which
enabled
novel
synthetic
pathways
selective
formation
substituted
anthracenes
through
cross-coupling
reactions.
The
function
ligands,
including
phosphines
N-heterocyclic
carbenes,
improving
reaction
efficiency
also
examined.
shift
towards
greener
noted,
with
focus
on
minimizing
waste
reducing
toxic
reagents.
Several
case
studies
demonstrate
successful
application
these
techniques,
highlighting
structural
diversity
functional
potential
derivatives
applications.
