Sustainable synthesis of benzimidazole-based Schiff base using reusable CaAl 2 O 4 nanophosphors catalyst: Insights into metal(II) complexes and DNA interactions DOI
M. Manjunath,

F. H. Sujata,

A. H. Shridhara

et al.

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 19, 2025

This article presents a new and facile method for the synthesis of Schiff base compounds with benzimidazole group using low-cost reusable calcium aluminate nanophosphorus catalyst (CaAl2O4). approach avoids harmful solvents reactants, supporting more environmentally friendly process. The maintained its activity heterogeneity over four cycles minimal loss efficiency. process was straightforward eliminated need column chromatography. ligand (HL=(E)-N-((6-(thiophen-2-yl)pyridin-2-yl)methylene)-1H-benzo[d]imidazol-2-amine)) synthesized by reaction 6-(thiophen-2-yl)pyridine-2-carbaldehyde 1H-benzimidazole-2-amine. Subsequently, metal(II) complexes Co(II), Ni(II), Cu(II) were prepared this ligand. Structural analysis both metal carried out various physicochemical spectroscopic methods. Ni(II) Co(II) found to adopt an octahedral geometry, while complex exhibited square-planar structure. Binding studies calf thymus DNA (CT-DNA) at pH 7.2 performed UV-visible spectroscopy, viscosity measurements, thermal denaturation showed that intercalate into produced distinct binding pattern. Molecular docking simulations AutoDock Vina provided insights interaction these B-DNA dodecamer. Furthermore, photonuclease against pUC19 DNA. Agarose gel electrophoresis exhibit photoinduced nuclease activity, confirming their ability cleave upon exposure light.

Language: Английский

Sustainable synthesis of benzimidazole-based Schiff base using reusable CaAl 2 O 4 nanophosphors catalyst: Insights into metal(II) complexes and DNA interactions DOI
M. Manjunath,

F. H. Sujata,

A. H. Shridhara

et al.

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 19, 2025

This article presents a new and facile method for the synthesis of Schiff base compounds with benzimidazole group using low-cost reusable calcium aluminate nanophosphorus catalyst (CaAl2O4). approach avoids harmful solvents reactants, supporting more environmentally friendly process. The maintained its activity heterogeneity over four cycles minimal loss efficiency. process was straightforward eliminated need column chromatography. ligand (HL=(E)-N-((6-(thiophen-2-yl)pyridin-2-yl)methylene)-1H-benzo[d]imidazol-2-amine)) synthesized by reaction 6-(thiophen-2-yl)pyridine-2-carbaldehyde 1H-benzimidazole-2-amine. Subsequently, metal(II) complexes Co(II), Ni(II), Cu(II) were prepared this ligand. Structural analysis both metal carried out various physicochemical spectroscopic methods. Ni(II) Co(II) found to adopt an octahedral geometry, while complex exhibited square-planar structure. Binding studies calf thymus DNA (CT-DNA) at pH 7.2 performed UV-visible spectroscopy, viscosity measurements, thermal denaturation showed that intercalate into produced distinct binding pattern. Molecular docking simulations AutoDock Vina provided insights interaction these B-DNA dodecamer. Furthermore, photonuclease against pUC19 DNA. Agarose gel electrophoresis exhibit photoinduced nuclease activity, confirming their ability cleave upon exposure light.

Language: Английский

Citations

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