Synergistic Anxiolytic Effects of Linalool and Sesamol Co‐Treatment on Swiss Albino Mice: A Potential GABAergic Intervention DOI
Muhammad Torequl Islam, Md. Shimul Bhuia,

Md. Shadin Mostakim

et al.

Synapse, Journal Year: 2024, Volume and Issue: 79(1)

Published: Dec. 27, 2024

ABSTRACT Sesamol (SES) and linalool (LIN) are aromatic compounds that have neuroprotective effects. The main purpose of this study is to evaluate the anxiolytic activity LIN SES co‐treatment on Swiss albino mice analyze its possible mechanism through in silico study. In sense, were given gamma‐aminobutyric acid type A receptors (GABA ) agonist diazepam (DZP; 3 mg/kg, p.o.) as a positive control. vehicle (10 mL/kg) was served tested chemicals, single‐dose (50 mg/kg) mg/kg), well combination (LIN + SES) (DZP SES), administered orally order conduct several behavioral tests, including open‐field, swings box, hole‐crossing, dark‐resident time tests. Further, molecular docking studies LIN, SES, DZP carried out different software. results showed individually significant anxiolytic‐like mice. when combined with (SES DZP), it exhibited relatively lower locomotor compared individual treatment groups, indicating synergistic action. addition, analysis revealed moderate binding affinity (−5.0 −5.1 kcal/mol) toward GABA receptor α3 subunit. conclusion, our findings suggest exerted mice, possibly GABAergic interaction pathways.

Language: Английский

Synergistic Anxiolytic Effects of Linalool and Sesamol Co‐Treatment on Swiss Albino Mice: A Potential GABAergic Intervention DOI
Muhammad Torequl Islam, Md. Shimul Bhuia,

Md. Shadin Mostakim

et al.

Synapse, Journal Year: 2024, Volume and Issue: 79(1)

Published: Dec. 27, 2024

ABSTRACT Sesamol (SES) and linalool (LIN) are aromatic compounds that have neuroprotective effects. The main purpose of this study is to evaluate the anxiolytic activity LIN SES co‐treatment on Swiss albino mice analyze its possible mechanism through in silico study. In sense, were given gamma‐aminobutyric acid type A receptors (GABA ) agonist diazepam (DZP; 3 mg/kg, p.o.) as a positive control. vehicle (10 mL/kg) was served tested chemicals, single‐dose (50 mg/kg) mg/kg), well combination (LIN + SES) (DZP SES), administered orally order conduct several behavioral tests, including open‐field, swings box, hole‐crossing, dark‐resident time tests. Further, molecular docking studies LIN, SES, DZP carried out different software. results showed individually significant anxiolytic‐like mice. when combined with (SES DZP), it exhibited relatively lower locomotor compared individual treatment groups, indicating synergistic action. addition, analysis revealed moderate binding affinity (−5.0 −5.1 kcal/mol) toward GABA receptor α3 subunit. conclusion, our findings suggest exerted mice, possibly GABAergic interaction pathways.

Language: Английский

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